- A few disturbing implications about the Kanker Sisters and their views on romance are raised in their debut episode.
- To be more precise, they have three robes with male names attached in their mother's trailer, implying there are three fathers and that they are half-sisters. Throughout the episode, the Kankers do their best to look after the Eds, only to be exploited for food and entertainment. When the Kankers get upset about this, the Eds are unsympathetic and opt to leave, only for the Kankers to demand child support for their "children"note . The Eds run away in fear, and the Kankers swoon as they retreat, remarking that they run away "just like a real man".
- "Fa, La, La, La, Ed". When Eddy tries to scam the other kids into stealing their piggy banks, Ed exposes him by ripping open the giant piggy bank machine revealing Edd with a hammer about to smash Jimmy's piggy bank. Edd is so overwhelmed by shame that it causes him to burst into tears.
- "Momma's Little Ed". Eddy throws Edd out of his room, but Ed's sadness make Eddy change his mind.
- Everyone saying goodbye to Jib in "Who Let the Ed In?".
- Rolf tearfully longing to go back to his old country in "Wish You Were Ed".Rolf: I grow tired of this-this cold cement, this-this twisted steel of industry, this confusing leisure delights, and your ill-at-ease customs! Rolf sweats himself to understand your "modern go-go" world, but he yearns the simple life... the life once had in the old country (pulls out a locket and looks at a picture of himself in his home country)
Edd: Are you all right, Rolf?
Rolf: My heart! My heart! It's broken... Rolf longs for the old village (walks away with Wilfred while covering his eyes)
Eddy: Geez, talk about killin' a mood.
Edd: Rolf's frustrated, Eddy. How difficult it must be to adapt to a new way of life. To put aside handed down beliefs, and be pulled between two cultures.
Ed: Rolf's homesick, Eddy.
- This is even sadder if you recall that Rolf is heavily based on series creator Antonucci himself, being the son of first-generation Italian immigrants, who had to learn to adapt to a whole new country and culture as a child.
- After the kids laugh at Eddy in "X Marks the Ed", poor Eddy retreats to another part of the house. Edd cries "Eddy, wait!" the look on him is heartbreaking.
- After Edd's awesome moment, Ed leaves the house. Edd doesn't want to and beckons him back, but you can see the look of shame on Ed's face after he laughed at Eddy.
- Eddy walking through the cul-de-sac cold and alone in the Christmas Special, which leads to a Heartwarming Moment as he walks up to a Christmas tree, notices a shorted-out light and replaces it with a light he's been holding the whole episode, which causes the tree to shine like never before.
- Eddy: (voice breaking) "Let me in, Kev, please? All I want is a good Christmas."
- May Kanker sobbing by herself in the closet because Ed was terrified and disgusted by her and her Valentine's card, despite normally being the unflappable Ditz.
- Her sisters teasing her about the card she wanted to give to Ed, too.
- "A Fistful of Ed". Edd being sad because everyone believes him to be a bully. There's also the scene where Ed tells him that they can't be friends anymore and they both start crying. You even see Ed's heart literally break in that scene. The picture of Edd crying (illustrated above) is from this episode.
- The scene where Edd cries to himself alone in the science room. And after that, the scene where Jimmy witnesses Edd nurse a flower and makes it bloom, proving to him that he's not the monster he's being made out to be.
- At one point, Eddy doesn't realize that Edd wasn't actually beating Ed and told him he went a little rough on him. Edd, tears streaming from his eyes, shoots him an angry look.
- "Take This Ed and Shove It" has a bit of a depressing one where Old Eddy starts breaking down after realizing he really is old and will never be a kid again, beating himself senseless with a cane and then seemingly waking up as a kid and learning that he only passed out when they were trying to get the jawbreakers, only to wake up again as an old man again and coming to terms that they are all old and he was only reliving his memories in his sleep. And this was going to be the original ending to the series before it came back.
- "A Case of Ed". The scene where Edd is giving away his stuff because he thought he was dying.
- Heck the whole episode was sad, the nicest character on the show thought he was DYING. The fact that he trusted his friends only to find out they were joking is just insulting.
- In "For Your Ed Only", when Sarah tearfully says, "I want my diary!" Anybody would be upset over losing something so personal, and she sounds genuinely broken up over it, with none of her usual grating shrillness.
- It's very upsetting when Jimmy's belief in fairy tales and magical creatures gets crushed in "Tinker Ed". There's a particularly heart-wrenching scene where Jimmy, in denial, tearfully reads a picture book about fairy tales in his front yard, constantly telling himself that they do exist.
- There's an episode where the Eds introduce Jimmy to a happy park called "Smileyville" (they even produce a map for him) in order to cheer him up. It apparently works, and Jimmy happily enters through the Smileyville gates, excited to take part in all the fun things the park has to offer (such as a teddy bear picnic). Upon entering, however, he discovers that Smileyville is no more than a dirty, disgusting alley. Fortunately, Rolf steps in to console the crying Jimmy and get back at Eddy for crushing his hopes.
- The episode "Pick An Ed" gets rather depressing concerning Eddy. He disguises himself as a new student named "Carl" in order to find out which of the other kids wrote something nasty about him on a wall. The other kids end up really liking this new persona though, and for the first time in his life, Eddy actually feels accepted. He enjoys it so much that he decides to stay as Carl forever. This becomes even sadder in hindsight after the movie, where we find out that he secretly hates himself.
- There's one moment that's particularly sad. When Kevin first meets "Carl," he raises his hand up to him for a friendly fist-bump. Eddy immediately flinches.
- The other kids psychologically torturing Eddy into having a straight up panic attack in "Smile for the Ed".
- Considering what little we know about the Eds' home lives, all three of them seem to suffer in some way. Ed probably has it the worst, since Sarah is constantly threatening to tell their mother on him (and it's implied that she often gets her way), and his dad seems apathetic to the whole thing at best ("AND DAD WILL JUST SIT THERE AND WATCH TV!"). Edd's parents communicate with their son through sticky notes, which could indicate that they're not at home much. And then there's Eddy's home situation especially with his brother. If his parents' off-screen appearances are anything to go by, they're overly strict at best and outright abusive at worst.
- This fanmade comic◊, which depicts Eddy tearfully saying goodbye to his buddies before moving out of the cul-de-sac. It's bad enough to see the lovable trio part ways like that, but it really hits hard for people who actually had to go through this with their friends.
- "See No Ed" is A Day in the Limelight for the other kids when the Eds are mysteriously absent. At first they are overjoyed by them being seemingly gone, but then this elevates to suspicion and later even concern. The kids actually start to feel bad for the Eds, regretting this supposed dream outcome. Some of them even acknowledge how vindictive and bitter they become around them, but they're just that infuriating an element of their life (Jimmy admits woefully that he spent every birthday wish essentially wishing in desperation that they would go away forever).
- "Dueling Eds": Rolf's reaction to seeing Eddy destroy the Sea Cucumber that he had brought out as a way of celebrating his great Nano's voyage across the sea. To add insult to injury, Eddy's only reaction is to call it a "stupid fishball."
- Edd having a Heroic BSoD in "Too Smart for His Own Ed" when he loses the Spelling Bee to Ed. It doesn't help that the kids treat him as if he's dumber than Ed. He gets better when he acts like a good friend by congratulating Ed for his victory, rather than being bitter. The episode also turns into a Bittersweet Ending for Edd, as he doesn't share the blame with Eddy for his scam gone awry.
- The way Ed is treated by his family and Sarah come off as this.
- The ending of "A Twist Of Ed" is one for the Eds. Finally fed up with being harassed and assaulted by the Kankers, the Eds plot to get rid of them by using Reverse Psychology, giving them a taste of their own medicine. It is actually working at first, Ed and Double D are having fun getting payback on the Kankers and they are one small push away from being rid of them once and for all. But because Eddy can't hide his fear of the Kankers, they ultimately turn the tables on the Eds by pretending to be scared and luring them into a trap. Despite coming close to having the biggest bone thrown at them by having the Kankers leave them alone, instead they just get one big yank from the chain and have the Kankers more attracted to them then ever, and are trapped in a room for a kissing session for as long as the Kankers want. Also that is the second time they have to endure one from the Kankers that day.
Eds: WE'RE TOO YOUNG!!! AHHHH!
- Also, the way the Kankers trick the Eds shows something about how they view their "relationship" with the Eds. The Kankers, being Loving Bullies are no strangers to forcing kisses on the Eds at random or even after humiliating them. But even before they could be excused as just teasing the Eds, or could have believed that kissing them was their prize for beating them at whatever "game" they thought they were playing. Even at the beginning of this episode, assaulting the Eds in their own homes could be their own twisted way of showing them they love them (flirting with them, inviting them to kiss them back, hugging them, and even Lee trying to have a Shower of Love with Eddy). Here though, they realize what the Eds are trying to do, realize this isn't a "game" or a "date" and choose to get revenge on the Eds. Once they realize what the Eds are doing they grin evilly and immediately lure them into their trap upstairs and mock their attempts to get rid of them by pretending to still be scared of them. Once the Eds have their guards down they pounce on them, restraining them in the most painful ways they can. This includes May pulling Ed into a closet where she can be heard doing something to him off-screen and Marie grabbing Double D by the cheeks, forcing for him to pucker up and kiss her back. This is perhaps the biggest example Take That Kisses the Kankers have given the Eds, because it is like they are reaffirming their "dominance" in their "relationship" with the Eds, or simply refusing to let the Eds "breakup" with them. Unlike the beginning of the episode, the Kankers aren't kissing the Eds out of love, but revenge. No flirting this time, no attempt at gentleness, and no choice given to the Eds, the Kankers are going to make them kiss them back this time and love them as much as they claim to love the Eds, whether they want to or not.
(Cut to the outside of the trailer as kissing can be heard)
- "Look Before You Ed" is dedicated to Paul Boyd, who tragically died in Vancouver, Canada on August 13, 2007 when he was shot by a police officer.
Tear Jerker / Ed, Edd n Eddy