All spoilers regarding the series will be left unmarked.
When the unnamed woman gets her baby daughter Serra confiscated just because Serra was a Norma. The woman's cries and pleas for Serra to be returned to her fall on deaf ears.
Sophia Ikaruga Misurugi's death. She takes a policeman's gunshot meant for Ange in a Heroic Sacrifice in front of the latter. Anyone who has ever lost a parent will know her sorrow.
Even though she is saved by Embryo moments later, Chris getting shot in the head mid-takeoff, and Rosalie's tearful reaction is heartbreaking. Given how close the two were, and how fearful Chris has always been of dying.
And then there's the reunion. Despite being a Mauve Shirt, Rosalie's disbelief that Chris killed her pupil is heartbreaking. And the trio's friendship, damaged when Chris reveals that she's always been resenting both Rosalie and Hilda for always being left out.
Embryo may be the Big Bad and everything, but picture this: imagine being a witness to five different world wars before creating another world and find out that humans still haven't changed from their ways. No wonder he's so fed up and wants to recreate the world again. By any means necessary.
Ange and Hilda's reunion with their "loved ones", especially towards the end of "Traitorous Homeland". Let's just say a number of people want to give the both of them a hug on that one. Ange's reunions are particularly cruel when her former teammate and her little sister deliberately string her along before lashing out at her for being a Norma.
Hilda, Tusk and the remaining Norma learning what really happened to Jill after thwarting the latter's escape attempt in "God's Soul Searching". Jill's efforts to become a respected hero of the Norma were all but destroyed when she was seduced by Embryo instead of killing him at the first chance, getting her comrades killed in the process.
In "Necessary":
Jill realizes that if she was nicer to Salia, she wouldn't have turned on them.
One has to feel for Ersha in the second half of the episode. She experiences a Heel Realization after Embryo's manipulation of her to fight her friends came with a heavy loss to the point that Embryo abandoned her.
Chris leaving the Norma to join Embryo is definitely sad. Hilda and Rosalie clearly considered her one of their closest friends regardless and are genuinely upset that she betrayed them.
Their legitimate cluelessness to Chris thinking she was abandoned during the invasion and envy about being the third wheel in their friendship are just a few things that could have been resolved had her been open about it.
Unfortunately for her, her new life with the Diamond Rose Knights is quickly taken away from her at the last moment. With Embryo leaving her to die after failing to capture Ange, Chris realizes she's been abandoned again. Now that she has burned all bridges with people whom she cares about, she realizes her betrayal wasn't worth it. No wonder she goes Ax-Crazy and going on a shooting spree, resulting in Tania and Irma's deaths. Fortunately, Hilda and Rosalie snap Chris out of it and they reconcile.
The current predicament for Sylvia, especially after the end of "Distorted World". True, she tortured her sister and posed as a cripple for much of her life. But she also witnessed her mother's demise and was tricked by both Liza and Julio into hurting Ange. Her "My God, What Have I Done?" reaction is understandable, considering that she'll never see her sister again. Technically, she has no one to call family anymore and she knows the last of the incidents is her fault.
Fortunately, Super Robot Wars V manages to mitigate this, and it becomes a minor Heartwarming Moment when Sylvia does reunite with her sister after being pulled into all the chaos. In the Golden Ending, she's now working to topple the old order.
