- Cain giving his sash to the mortally wounded Donal in Cain's Last Stand. Especially because he wasn't actually mortally wounded and he survived to be mind-controlled by Varan. Later, he comes in contact with Jurgen which gives him enough clarity to apologize to Cain and shoot himself when he can't break the spell.
- As Cain and his Commissar Cadets are evacuating the Schola Progenium, he looks around his surroundings and notes that the Schola, and in extension Perlia, is the closest thing he's known to a home. Given that he's gone at length throughout his memoirs about how unpleasant the galaxy could be, it's surprising coming from him.
- Cain spends his entire life behind his cavalier facade and never makes any meaningful connections or fully entrusts himself to anyone, not even Amberly despite their century-spanning romance. A telling moment is his second conversation with her wherein she gently suggests that he could try being himself. He nearly shits his pants thinking she's a psyker and might have him shot for cowardice, completely missing her point. That's sad.
- Jurgen's Blank nature. Sure, total immunity to the Warp is a nifty trick, but it totally cuts him from other people. They immediately recoil when he's around - okay, the odor probably doesn't help - and tend to forget he exists. He likely was ostracized his whole life for something he had no name for and no way to help. Taking that in account, no wonder he's fanatically loyal to Cain — the Commissar was the first person to treat Jurgen as if he was someone instead of an aberration.
- When visiting the dam at night in Cain's Last Stand, Cain is attacked by a combat servitor and has to take cover behind a convenient pillar. Upon returning to the site the next morning, he sees the names inscribed in the pillar, and realizes it's not just any statue: it's a monument to everyone who died on the March of the Liberator. Once again, he's saved by the people who gave their lives for him.
- The Apocalyptic Log of well-meaning governor Jona Warden as he's infected with the Plague of Unbelief.
- The deaths of Holenbi and Velade in the first book right after a Hope Spot they were ok.
Tear Jerker / Ciaphas Cain