- At the end of Blue Submarine No. 6, if you don't shed a tear for Verg even though he is a bastard, you have no heart.
- Seeing Mutio being abused by Verg and scorned by her sisters is more then painful for everyone who ever has experienced bullying.
- The scene in episode 2, where Mutio finds out one of her sisters was killed during the battle, and starts sobbing and shaking all over.
- The dying whale. The fact that Mutio first frantically tries to stay with him during his dying moment, just to sing for him with an emotionless expression once he has died makes it all the worse.
- The deaths of the Twins in the PS1 game.
Tear Jerker / Blue Submarine No. 6