As a Moments subpage, all spoilers are unmarked as per policy. You Have Been Warned.
- Lana learning that she has been committed by her girlfriend.
- Lana discovering that her girlfriend has been murdered by Bloody Face/Dr. Thredson, and that she is now his prisoner and they will "continue" her aversion therapy. By using her girlfriend's corpse.
- Lana's final confrontation with Dr. Thredson. What really makes it a tearjerker is that Lana is only confronting him because she wants to know what Bloody Face did with Wendy's remains. Lana comments how she's the only person who cares because Wendy was a lesbian. Somewhat sad Truth in Television.
- The look on Shelley's face whenever the schoolchildren run away screaming from her. She just wants someone to help her out!
- The way she finally dies is even worse.
- Dr. Thredson's origin story, but that quickly crosses over into Nausea Fuel and Squick when he mentions the medical school cadaver.
- The Alas, Poor Villain death of Dr. Arden. Heavy YMMV due to him being a Nazi, but here was something who yearned to be considered a 'visionary' and was so twisted that he was unable to form anything approaching a normal relationship. He laments that he never had any innocence, even as a boy, and reveals that he is exceptionally lonely...the only solace he takes is in his own intelligence and the innocence of Mary-Eunice. However, Pepper informs him that the aliens (who he sees as equals) laugh at his experiments and consider him a quack, meaning the 'path' he followed was all for nothing. He loses faith in his own motivations, ending his experiment while declaring that his life's work is a 'farce'. Then Mary-Eunice dies, leaving him completely alone in the world. Distraught, he tearfully burns himself alive with her. Deserved due to his horrible acts, but somewhat sad nonetheless.
- Everything the Monsignor goes through.
- "Take me away."
- Sister Jude/Judy reacting to Pepper's offscreen death.
- Alma's breakdown, institutionalization at Briarcliff, and then her second death. Kit stands over her body at the morgue, apologizing that he couldn't do right by her.
- Sister Jude's death.
- The fates of Happily Married Leo and Teresa at the hands of several Bloody Face Jack the Ripoffs is a particularly dark, grim, and disproportionate Sex Signals Death scenario.
- Johnny and Lana's confrontation, where he breaks down in tears after she shows him motherly affection, confessing that he'd done awful things... and then she shoots him in the head with his own gun.
- 90% percent of all characters in that picture on the main page? They're all dead.
- Pretty much any scene involving Shachath is guaranteed to be a tear jerker.
- Sister Jude more than earned a comeuppance, but her Trauma Conga Line is just awful. When her sanity finally breaks in The Name Game, the sudden cheerful, happy song just makes it all the worse.
- Mother Superior Claudia, the only character on the show who's never wished harm on anyone nor asked for anything for herself, sacrifices her career to free Lana from Briarcliff. It's implied Cardinal Howard reassigns her out of revenge, but nobody — Lana and Jude included — cares to follow up on her.
