- The helicopter crew from Vol. 4 are from "some news station... the one with the asshole weatherman" referencing Romero's Dawn of the Dead (1978).
- Rick and Shane find a zombie that looks a lot like MC Frontalot eating a deer. He is wearing Frontalot's signature glasses and tie, and has a nametag that reads "FRONT."
- In the first issue we meet Morgan Jones and his son, Duane. Duane Jones was the name of the actor who played Ben in the original Night of the Living Dead (1968).
- When Michonne mentions some of the implements she plans on using for torture in her To the Pain speech, she includes a pair of pliers, a blowtorch, and a spoon.
Shout Out / The Walking Dead