- The helicopter crew from Vol. 4 are from "some news station... the one with the asshole weatherman" referencing Romero's Dawn of the Dead (1978).
- Rick and Shane find a zombie that looks a lot like MC Frontalot eating a deer. He is wearing Frontalot's signature glasses and tie, and has a nametag that reads "FRONT."
- In the first issue we meet Morgan Jones and his son, Duane. Duane Jones was the name of the actor who played Ben in the original Night of the Living Dead (1968).
- When Michonne mentions some of the implements she plans on using for torture in her To the Pain speech, she includes a pair of pliers, a blowtorch, and a spoon.
- During the Prison storyline, Maggie talks about the movies in the prison library and how fun it would be to have solar power to allow for having "movie night." She notes a copy of Kindergarten Cop being one of the movies there, saying that she's never seen the film, but was familiar with the "It's not a tumor!" line.
Shout Out / The Walking Dead