- Almost every quest in the game is named after some classic work of sci-fi.
- Some of the more direct examples include Stranger in a Strange Land, The Stainless Steel Rat, The Secret People, Brave New World, and many more.
- Others are puns referencing in-universe people, places, and things, like Slaughterhouse Clive or Canid's Cradle,note Makes Spacesuits, Won't Travel, The Illustrated Manual,note or The Doom That Came to Roseway.note
- There's even the occasional Western thrown in, such as Fistful of Digits.
- The colony ship was found October 23, 2320 — the Great War in Fallout began October 23, 2077. Also, the Earth Directorate was formed after a conflict that's literally just called "the Great War".
- Firefly references:
- A corpse in the wilderness on Monarch is surrounded by dead raptidons and it's clear that whoever they were, they went down swinging. What's that make them? A big damn hero, of course, and this is the description you get examining the corpse.
- A group of Woolly Cows randomly appears in the Unreliable's cargo hold, while ADA complains about the fertilizer shipments someone keeps ordering.
- The origin of Marauders as revealed in the Peril on Gorgon DLC is from a failed drug experiment - exactly like how Reavers were created.
- A letter in Phineas' lab mentions an obscure body in the SK system.
- The Plasma Cutter is blatantly the Plasma Sword from Halo with a lightsaber-style hilt.
- One of the loading screens shows an ad for "Spectrum Vodka, a taste for every class!" with impoverished workers drinking the red variety, guards limited to green, and purple seemingly reserved for executives and above. This could be a reference to Red Rising, Homestuck, Paranoia, Logan's Run, or any or all of the above.
- The anti-Philosophism "Dissidents in Our Midst" poster is parody of the notorious "Destroy This Mad Brute -- Enlist!" WWI-era anti-German propaganda poster, with a primal instead of a gorilla with a blonde mustache, a fainting man instead of a woman (possibly Lady Liberty) in the ape's arms, a stun baton instead of a broken club, and "Philosophism" instead of "Militarism" emblazoned on its helmet. The headline is also a pun on the Dian Fossey biopic Gorillas in the Mist.
- In one radiant conversation Parvati mentions to Vicar Max that she knows some French, such as omelette and fromage.
- The achievement 'Anything for a Friend' is represented by two muscular, bulging arms, one black and one white, locking hands in a very masculine handshake.
- The description for the unique weapon Thunder references the opening line of the Imagine Dragons song of the same name:Description: Perfect for a young gun with a quick fuse.
- The engineer of the doomed UDL gunship Cantankerous Canid spends her last seconds aboard the crashing ship Flipping the Bird at her captain... as a Mooninites reference: "It's too bad you can't see this because I'm doing it as hard as I can."
- One of Nyoka's quips after killing an enemy is "To shreds, you say?", a la Professor Farnworth tutting over the death of a colleague in the Futurama episode "I, Roommate".
- The assassin Sherman Bradshaw quotes Rick and Morty if you start a fight with him: "Here I go killing again."
- Pester Martin Callahan long enough about his Spacer's Choice headgear, and he will eventually tell you that "If there are self-made purgatories, then we all have to live in them. Mine can be no worse than someone else's."
- There are a ton of incidental Vampire: The Masquerade references strewn throughout Monarch, for whatever reason. The password to get into the Cascadia lab turns out to be "Antediluvian," where you're there to steal a stockpile of "Alta-Vitae" (Gratuitous Latin for high life; vitae is the vampire euphemism for blood) gas. When you reach Devil's Peak, one of the first people you encounter is Joy Voivode, which is an obscure in-game term for a leader in the Tzimisce clan.
Shout Out / The Outer Worlds