- During the auction scene, Ernie greets one of his guests with "Hakuna Matata". Nathan Lane voiced Timon in The Lion King.
- For bonus points, Ernie Sabella (the voice of Pumbaa) had a cameo earlier in the film as the owner of the pound.
- If the whole plot wasn't reference enough, the Catzilla scene is basically a live-action Tom and Jerry cartoon, even sporting some of the slapstick from there. Notably making chase tunes as they run around inside a piano.
- Also, when Catzilla smashes out of its box, it roars like Godzilla. Rather apropos, given the cat's name.
- When the mouse chews through the dumbwaiter's ropes, Catzilla gives a Wile E. Coyote double-take before plummeting to his demise.
- "I know some people who used a mouse as a spokesperson. It turned out pretty well." Doubly funny when you realize that this movie was one of DreamWorks' first films, and they're one of Disney's main competitors.
- The mouse clinging to the bottom of the brothers car as a scare chord plays.
- The portrait of Rudolf Smuntz magically changes from a dour expression to smiling when his descendants make a significant change in their behavior, just like the portrait of Viktor Frankenstein.
- In a reference to a different Mel Brooks movie, Ernie yells "DOUBLE! DOUBLE! DOUBLE!" at his brother during their Volleying Insults scene. Hilarious in Hindsight, as Nathan Lane would later star in the Screen-to-Stage Adaptation as the character who says this line.
- TV ads of the movie in Brazil have a caption saying the mouse thinks he's The Incredible Hulk.
Shout Out / MouseHunt