Richmond Trinity Hospital Chief Nursing Officer Christina Hawthorne (Pinkett) loves her job, despite the endless days and nights she spends in the hospital. She goes out of her way to help her patients and advocate for her staff, sometimes violating protocol or standing up to administrators or doctors, who sometimes forget the true purpose of the hospital, but her intense focus on work affects her personal life, as she is a single mother who lost her husband to cancer and is trying to raise a rebellious teenage daughter. She later enters a relationship with Chief of Surgery Dr. Tom Wakefield (Vartan). Dr. Wakefield wants commitment and she is still unsure if she can become close with someone else. In season three they get married and face challenges including loss and infidelity.
On September 2, 2011, it was announced that TNT had decided not to renew the series for a fourth season, so the Season 3 finale, a Cliffhanger, was the series finale.
This series features examples of:
- Acceptable Professional Targets: Social workers. The hospital social worker on the series is an overweight, frumpily dressed white woman (as compared to the hot-looking nurses and the lead, who's a Black woman) who can't seem to do anything right or doesn't care enough about people to help. Then of course the title character (played by Jada Pinkett-Smith) comes in and makes everything better.
- Cliffhanger: The Season 3 finale (and due to the series' cancellation, the series' finale). Nick comes and talks to Christina asking her if she's scared of him. He puts a gun to his heart and says this is where Christina and him live. After Nick leaves, Christina locks the door and upon hearing a gunshot she sees a car speeding past that looks like Tom's car. Nick is injured but still breathing and Christina lays with him trying to call for help.
- Cute Clumsy Girl: Kelly has at least some of these traits, being a very nervous young nurse who lacks confidence and Apologises a Lot.