American McGee's Alice: Washu, having gone insane after a traumatic house fire, is committed to an insane asylum when she is wisked away (or is she?) to Wonderland...a super grim Wonderland, but still.
Bayonetta: Hot WitchMotoko Kusanagi goes around beating up demonic angels while finding out more about her past. Along the way she meets an equally Hot Witch named Crimson Viper gets chased around by Waver Velvet (who believes that Motoko killed his father), and gets stuck looking after Shinku who turns out to be a time-displaced younger Motoko. Motoko also buys weapons from Batman throughout the game.
Bioshock Infinite: Father Fujimoto must bring Touko Fukawa from a Steampunk sky-city called Columbia, which is led by the incredibly racist Penguin, to a mysterious man in New York to wipe away his debt. Along the way, he'll receive cryptic advice and help from Kiyomi Ikezawa and her twin brother (who are actually the same person) and have to deal with a populist rebellion led by Ragyo Kiryuin. Touko is revealed to be Fujimoto's daughter, and Fujimoto and Penguin are actually the same person.
BlazBlue: Calamity Trigger: In a world trapped in a Time Loop, Gintoki Sakata is being hunted by his brother Natsu Dragneel along with Kanashi Hokke* from Akahori Gedou Hour Rabuge, who seemed to be accompanied with Kyousuke Kousaka, while Gintoki is being stalked with Rin Tohsaka. Elsewhere, Yammy Riyalgo was sent to capture Gintoki and attempted to bring back his estranged old friend Arfoire to his base, though failing and Arfoire herself tended into a cute boy named Puchiko. In the end, it turns out that the time loop is caused by Kyousuke, whose true name is Tomoya Okazaki. Gintoki broke through the time loop...
BlazBlue: Continuum Shift: Tomoya, still in Kyousuke's disguise, assigned Makise Kurisu to hunt down the rebelling Natsu and Kanashi, while he recruited Arfoire into his ranks. Kanashi turns into a monster and Gintoki, Natsu, his future self and Rin had to stop her, only to be greeted by the formation of the new enemy group: Tomoya, Makise, Arfoire, and Puchiko's dad Archer.
Disgaea 3: Absence of Justice: Gyororo, the top Honor Student, decides that the best way to defeat his father is to become a hero, so he steals the title from Allegretto, who has come to defeat Gyororo's father since it's been rumored that Princess Mia would be captured by him even though Mia is actually a much better fighter than Allegretto. Standing in Gyororo's way is Natsumi Hinata, his rival and resident Delinquent.
Disgaea Dimension 2: Yuuno, Mikoto, and Sakura return in an attempt to launch a PR campaign when Ram comes in and claims to be Akuma's daughter and Yuuno's sister. Meanwhile, Bison says Yuuno sucks as an Overlord and tries to replace him with Yuki Nagato.
Dissidia Final Fantasy: For years, Nausicaa and Chiyo's Dad waged war over light and dark respectively. This time, they have summoned their own armies of warriors for the ultimate showdown between good and evil.
The Third: After the events from the last game, Gabriel reunites with a sister and friend of him named Will Vandom and after pursuing Shinjiro Taiga, (not to mention dealing with Akira's parents, Kaname Chidori and Napoleon Dynamite) they were sent to Another Dimension. Now, with the help of the cast of the previous adventure, they must find find a way to get out from there, but first they must face Heero again, along with Will's dead sister and Gabriel's mentor Bulma, whose spirit was posessed by Kamen Rider Skyrider. Gabriel and the rest of the cast are helped by Videl's ancestor Elizabeth Swann.
Metal Gear Solid 4: Guns of the Patriots: Xehanort, now an old man assisted by a cyborg Pain, Fujitaka's adoptive daughter Miria and Sachiko, accepts a mission from Basil to terminate his brother/rival Scotsman, who commands Byakuya and four mentally disturbed women including Amika Kurebayashi and Mordred. Two of them turn out to be controlled by Kunzite. Along the way, Xehanort meets his mother Yubaba, Kano turns out to have nanomachines that stop her cancer from killing her, and Sachiko marries Lelouch. In the end, Xehanort tries to commit suicide, but is stopped by Master Xehanort.
The Vermilion Destroyer: Hinata's rival, Bayonetta goes on a quest to sacrifice his siblings. It turns out that Bayo is actually Hinata's sister and also one of Dandy's first creations alongside the Final Boss.
NieR: Automata: Eight thousand years later, Earth is being invaded by aliens using "machine lifeforms" they control. Androids are built and dispatched to combat those machines. Mikasa Ackerman and Taichi Yagami are some of these androids. Agil is Mikasa's support unit, and Elise is a prototype to both Mikasa and Taichi.
Octopath Traveler: Eight heroes wander the land of Orsterra in search of finding their own purpose in life:
Darkness, a priestess on a pilgrimage to restore light to the world;
Goblin Slayer, a teacher in pursuit of a book that had long gone missing from the royal library;
Riina Tada, a merchant traveling the world for the best bargains and the rarest items;
Kamina, a retired knight searching for the reasons behind his former partner's betrayal;
Android 21, a dancer seeking revenge on the criminal gang who murdered her father;
Gilgamesh, a medicine man on a journey to heal the sick;
Kirito, a thief ordered to steal a set of rare gemstones; and
Marida Cruz, a huntress looking for her master, who suddenly disappeared during a hunt for a highly dangerous beast.
Phantom Brave: Len is a girl who lives on an island and is rejected by society at large because of her ability to see spirits. Her only friend is a dead boy named Hiro Hirono, who, along with other spirits, help her complete various jobs to support so that Len is able to support herself. During these jobs, they come across Yuri Lowell, who tries to take their reward in order to support his sister Moe Mizukoshi.
In the Updated Re-release, everyone dies and Len and Hiro encounter White Len who forces them to train so that they can take on the final boss.
Nekketsu Seisyun Nikki 2: The above are further joined by student newspaper reporter Aki Hinata and swimmer Kisuke Urahara.
Project Justice: A new wave of school violence breaks out, this time headed by Broly. His plans include dressing up as Joe and ruining his good name, brainwashing Genie (now Mario Auditore) into doing his dirty work, having his older sister Athena befriend Viola and ordering Shampoo to try and seduce Keitaro. Athena however betrays him and with the help of Viola and Ryoko stops his plans, but not before Broly can summon the spirit of Dio and Gray Fox's father, killing off Fox and causing Dio to disappear.
In the movie, while Roger has just left France, The Virgin Mary, an American, is sent to Tokyo to work for the rest of the cast while Roger is in Paris, so that she would go on to found her own in the States. But darkness comes as the American company, Douglas-Stewart, under the leadership of Ryoji Kaji and his dragon, Axl Low, unveil an evil plan.
Skullgirls: Several girls compete for possession of the Skull Heart, an artifact which can bestow wishes on the victor but could potentially cost her soul. The combatants are: Kirino Kosaka, an amnesiac school girl who fights with the help of a parasite that forms Prehensile Hair, Bullet, a circus performer in the employ of the mafia whose weapon is a hat with two giant muscular arms, Gretel, a young girl with a damaged psyche who has been experimented to effectively become a living cartoon, Suigintou, a princess with a napalm-tossing umbrella and a unit of crack troops at her command, Chiaki Nanami, a catwoman with an undying body whose attacks involve throwing her head at her enemies, Rainbow Dash, a Child Soldier who has been tortured and mindraped into being a Living Weapon, Kurisu Makise, the psychotic nurse who did the experiments on the former, and Kinu, an Eldritch Abomination who can transform into other combatants. In the end, one of them faces off against Kanon Nakagawa.
Steins;Gate: Light Yagami likes to imagine himself as a mad scientist, who accidentally sends a message to the past, which undoes Tsubaki Yayoi's death. She later joins the makeshift lab technically owned by Hidan, but is led by Light, of which computer expert OtakuGilgamesh and Akane Tsunemori are also members. Light and Tsubaki later experiment the mechanisms of time travel, which ropes in shy androgynous young Sasha Braus having a crush on Light, cat-girl but immensely intelligent and rich Maromi, part-timer Tenten, and shy phone-addict Melody, who uses the machine built by Light to experiment around and change their pasts. Unfortunately, preventing Tsubaki's death shifts the timeline into a new timeline where Akane has to die, which Light, Tsubaki and Gilgamesh has to undo, and Melody turns out to be a traitor working for Hidan. Similarly, Tenten is revealed to be a resistance member from the future and the original John Titor, and is Gilgamesh's Kid from the Future.
Street Fighter V: With his body failing, Lando makes one last attempt to take Hugo's body to keep himself alive, with his newest, poison-wielding lieutenant Don Kanonji and Lars and Caster back in the fold. Meanwhile, at the orders of Zelos, Pharah ressurects Nick (now Junpei Iori) and sends him on a mission with Homura to stop Lando. Q-chan (now the second Minnie Mouse) organizes her own cadre of fighters to stop Lando's plans including Kyosuke, Rukia, Asura, Chief Bogo, Santa, Judge Anderson, Angela (now Anzu Futaba) and Minnie's layabout servant Onizuka (now Argo Gulskii). Elsewhere, Emirati prince Saizo is searching for his missing friend Tohru, Brazilian fighter Mio Akiyama looks to promote her family's jiu-jitsu style, Lando clone Solf J. Kimblee looks for a new purpose in life, Darui's car goes missing, Egyptian fortune teller Futaba Sakura warns the fighters of their changing fates and all the while Humanoid AbominationRurio searches for strong fighters' souls to consume.
Super Robot Wars Original Generation Gaiden: Apollo fights off a bunch of Hokuto Shinken practicioners spearheaded by Guy Cecil and Garrod Ran. Meanwhile, Ryu and his team scavenged the remnants of Ian and Lancer, which they did. Then, Signum, Renais and Rushuna gets kidnapped by Kvar, and unfortunately Signum seemingly got killed, but she came back and Brainwashed, only for both Lancer and Iris to reappear (Yanagi as well), with Lancer snapping Signum back to her senses. Meanwhile, Guy betrays Garrod to save Apollo's sister Akira Kogami, and goes off on a rampage kicking the asses of Guan Yu, Nico Robin, Grand Fisher and Roy Mustang while getting help of Garrod AND Jun Kurosu/Joker-sama, all while dragging the other heroes to an eventual face off with Apollo's archnemesis... and when that's done, the tagging-along Jade betrays them and they kick his butt.
Part 1: Before all those happened, Leon Magnus got sucked into another world where he gets adopted and joins a four-man band consisting him, Hatake Kakashi, Belldandy and... uh, her boyfriend. Too bad said boyfriend die and Leon's rival Jade Curtiss killed Leon's adoptive father, and fled after witnessing the destruction of the world's capital. Leon then left Kakashi and Belldandy to fix things in the capital while he chases after Jade.
Part 2: After all those tales above, Leon has dragged Allenby Beardsley to that world, while Arche Klein filled up the empty spot. Leon, Allenby, Kakashi, Belldandy and Arche uncover prophetic mystery and defend their home from power hungry country and the return of the Dark God, who gets betrayed by Jade, and he became Leon's new best bud.
Option 1: Lain Iwakura is a dimension-jumping agent for a special forces group from a dimension where everything is terrible, lead by Oscar Vessalius. Oh yeah, she's also a robot created by The Great Will of the Macrocosm but nobody knows that. During the jump she suffered damage to her voicebox which scrambles her grammar and in spite of this nobody suspects a thing about her except for Chapel the Evergreen and Sasami. Lain eventually learns what it's like to be human, rebels against her creators and brings about their downfall.
Option 2: Knuckles is a dimension-jumping agent for a special forces group from a dimension where everything is terrible, lead by Zazu. Oh yeah, he's also their second-in-command and is going out with Minnie Mouse, their resident Mad Scientist (It's okay, Mickey doesn't know). And he has...AMNESIA which causes him to lapse into an incredibly silly version of himself. Silly Knuckles just tries to get by until his old comrades show up at which point he regains his memories and becomes Serious Knuckles, but his time amongst the people of this dimension has taught him that their ideals are wrong and he rebels, eventually bringing about their downfall. Minnie is not happy.
Tales of Berseria: Haruka Minami was an ordinary village girl whose world was afflicted with a mysterious disease that turned humans into demons. Even then, she led a relatively peaceful life until it was shattered one day when her brother-in-law Lt. Col. Yuuki murdered her younger brother Alphonse Elric as a ritual sacrifice. In the process, she was turned into a demon as well and was hauled to an island prison. For three years, her rage towards Lt. Col. Yuuki only grew, and when she was freed by the mysterious Beatrice she immediately embarked on a quest for revenge against him, who was by then revered by the world for halting the demonblight. Along her journey, she attracted a ragtag bunch of allies with varying agendas, starting with the demon swordsman Jouslain Tytania and self-proclaimed witch Eru Chitanda, followed by Emeralda Etouver, Ran Shuuei and finally the Demon Queen herself.
Time Crisis 4: General Pepper, in charge of an international police organization, discovers of a weapons smuggling plot in the United States. He sends his best agents, Absalom and Zarbon, to take care of the terrorists involved in the incident. Though the mission nearly ends up botched in the first stage, the two encounter Solid Snake, who was sent by the US military to also investigate the weapons trafficking. Backed up by Irene Lew, our two agents and Snake cooperate to uncover this incident. They will run into Falco Lombardi, Mr. Satan, and Killer Bee on the way.
Trillion: God of Destruction: Great Overlord Kyohei Hashimoto dies defending the underworld from a giant monster called Trillion. However, he was saved by the mysterious Kyoko Kirigiri and gave him a chance to defeat Trillion in exchange of his soul. And thus, aided by his Overlords, Noire the Overlord of Envy, Doppel, the Overlord of Greed, Nagisa Shiota, the Overlord of Gluttony, Isami, the Overlord of Lust, Sora, the Overlord of pride and Kyouka the Overlord of Sloth, Kyohei swores to defeat Trillion and save the Underworld and it's inhabitants like his younger sister Papi.
Secret of Mana:note Using the voice cast from the remake.Harry Potter mistakenly pulls the Sword of Mana out of a rock to cut a path back to town. Unleashing the Sword also opened its seal on evil, and monsters begin to ransack the world again. Back at the ranch, it doesn't take long for the pitchforks to come out, and the boy is exiled from his home forever. With nowhere to go, he is left with little choice but to fulfill his destiny as the Mana Knight with the help of Yukimura Kusunoki and Tracer who tried to con them out of their money. They are antagonized by both Kick-Ass and Leonidas. Narrated by Luna.
Trials of Mana:note Using the voice cast from the remake. The Mana Tree is dying (again), so the Mana Goddess sends her fairies to the world below to find someone worthy of restoring it. All but one perish on route due to the steady loss of magic, and the remaining Fairy, named Unikitty!, settles for the first heroes she can find. One of those heroes could be the knight Asemu Asuno, princess Ice, beast prince Cat Noir, half-elf Vanellope, thief Josuke Higashigata or the Amazon princess Supergirl.