- Assassin's Creed
- Assassin's Creed I: Tenten brings Sasuke to Cell's lab so that Sasuke can relive the genetic memories of his ancestor, Braeburn. Professor Oak then tells Braeburn to kill several of his enemies (such as Jack Fenton, Dukey, and Donatello) to regain his honor.
- Assassin's Creed II: Sasuke is rescued from Cell's lab by Tenten and Sam Puckett so that he can relive the life of another of his ancestors, Edward Elric. Assisted by his friend Jon Stewart and his uncle Wolverine, Ed begins to kill everybody responsible for his father's death.
- Batman: Arkham Series
- Batman: Arkham Asylum: Hamtaro helps Snips break out of jail. It's up to Asuma (with help from Squidward and his daughter Keesha) to round up the escaped inmates (including Billy Blazes, Chekov, Nico Robin, Kihuni, Gambit, and Diddy Kong. Nobita's dad is the jail warden and Bloo is a reporter.
- Batman: Arkham City: Nobita's dad has become mayor, leaving Goldar in charge of Arkham. Asuma must rescue Luke Triton from Raimundo. In the main plot, Asuma must fight Mr. Ratburn, Silas, SpiderMan, Sanji and his daughter Commander Shepard, and Clayface. Asuma's butler is Dragon Quest, and Sokka is his sidekick. Asuma has the option to fight Nigel Thornberry, Chekov, Diddy, Kihuni, Craig, and Max.
- Batman: Arkham Origins: In this prequel, Asuma must fight eight assassins: Billy Blazes, Craig, Raimundo, Shadow the Hedgehog, the Electrocutioner, Envy, Firefly, and Copperhead. Pegasus Seiya places a bounty on Asuma's head.
- Diablo III: The player is given the choice to be Qwark and Wuya the barbarians, Sai and Sakura the demon hunters, Harry and Hana the monks, Franky and Kate McAllister the shamans, or Jack Darby and Teresa the wizards.
- Ghostbusters: The Video Game: The player is the apprentice of Indiana Jones, Darth Vader, Kunta Kinte, and He-Man.
- God of War
- God of War II: After being revived by Woody Woodpecker, Killer Croc goes on a Roaring Rampage of Revenge against Charles Xavier. He also has to meet the sisters of fate named Gilda, Lindsay Funke and Clotho. Along the way, Killer Croc makes Typhon Eye Scream, Mercy Kills Nobita's dad, bashes Professor Sumdac's head into a door, hammers a barbarian king's head, impales Mr. Ratburn with a hook, tears off Greed's wings, is nearly crushed by Atlas, and accidentally kills a loyal follower.
- God of War III: The sisters of fate send Killer Croc to the past, where he keeps his rampage against Professor X alive. Killer Croc tears out Plankton's eye, amputates Wooldoor Sockbat's legs, steals the Riddler's soul, tears Gaara's head off and uses it as a lantern, and beat's Seto Kaiba's face up. Woody betrays Killer Croc. Princess Luna, the key to end the war, is found in a labyrinth with Greed's father King Kaioh.
- Harry Potter: Quidditch World Cup: Roger, Puar, Mr. Cake, Twilight Sparkle, Pinkie Pie, Shining Armor, Yugi Mutou, Harley, and Pride play Quidditch on broomsticks.
- Jak and Daxter
- Jak and Daxter: The Precursor Legacy: Roy Mustang and a mute hero save the world from Rei under the orders of Spanky Ham. The hero's love interest is Maddie Fenton.
- Jak II: Renegade: The hero (now SpongeBob SquarePants) and Roy are sent into the future, with Maddie and Spanky following them. Barbara Gordon becomes SpongeBob's ally, and he must now stop Deadshot and The Penguin.
- Jak 3: Wastelander: Giroro sends SpongeBob and Roy to the desert, where SpongeBob's father Kratos is king. Our heroes return in time to stop Giroro and Vegeta from taking over the world.
- League of Legends: There are many different characters to play as, including Sakura, Sailor Moon, Mindy Lahiri, Pegasus Seiya, Maud Pie, Discord, Iron Will, Mary Test, Kate McAllister, Patrick Star, Squidward, Batman, Mr. Gus, Monkey D, Luffy, and Ash Ketchum. Chuckie Finster is the announcer.
- The Legend of Spyro: Suzaku and his best friend Kristoff go on a quest.
- Mass Effect: The player (who may be Major Glory or Delia Ketchum) is told by Hovis and Kratos to stop Charles Xavier (who is assisted by Pride) from ending humanity. Glory/Delia must then form a team consisting of Agent Fowler, Kitty Pryde, the narrator of Batman: The Movie, Doris Trembly, Ezio Auditore, Roxy Richter, and ZIM. (Delia is offered a chance to have sex with Zim)
- Mortal Kombat vs. DC Universe
- The fighters of the Mortal Kombat universe are: a prime minister, Dracula, Freddie Benson, Zim, Shang Tsung, Sub Zero, Hovis, Hoity Toity, Wonder Woman, Tommy Pickles, Seiichi Yamamoto, and Knock-Out.
- The warriors of the DC Comics universe are Bummer, Rotor, Buster Bunny,Haku, the Flash, SpongeBob SquarePants, Wheezie, Ted's future son, Apollo, Captain Marvel, and Jack Fenton.
- Professor Laytonnote
- Professor Layton and the Diabolical Box: Terrorsaur and Huckle investigate the mystery of the Elysian Box.
- Professor Layton and the Unwound Future: Terrorsaur and Huckle recieve a letter from Future Huckle a.k.a. Yusei Fudo, who asks them to fight against Future Terrorsaur a.k.a. Batman. Yusei and Batman aren't really Future Huckle and Terrorsaur.
- Professor Layton and the Last Specter: First of the prequel arc, is about how Terrorsaur and his assistant Twilight Sparkle met Huckle for the first time. The town of Misthallery is being assaulted by a specter, and Terrorsaur must discover the truth. The specter is actually a digging machine built by Sanji in order to find a mystical land underground while attacked by a giant manatee from said mystical land.
- Professor Layton vs. Ace Attorney: Terrorsaur, Huckle, defense attorney Jason Lee Scott and medium Lina Inverse are warped into another dimension and go to save Mabel Pines, who has been accused of witchcraft.
- Ratchet & Clank
- Ratchet & Clank: Donkey Kong and his robot friend Mad Hatter search for Craig and fight Plankton with big-ass guns.
- Ratchet & Clank: Going Commando: Our heroes follow Mary Test and fight Professor Oak.
- Ratchet & Clank: Up Your Arsenal: Now Jumba is the bad guy, Persephone is a Britney Spears look-alike, and Silas is Jumba's butler.
- Ratchet & Clank Future: A Crack In Time: DK is now Spider-Man, and he and Mad Hatter protect time for The Tick.
- Scribblenauts Unlimited: Maxwell collects Starites to save his sister Twilight Sparkle from turning into stone.
- Skylanders: Spyro's Adventure: The player is a Portal Master who has to bring the Skylanders back to Skylands after being banished on Earth by Harley. The player is helped by Silverbolt, Nappa, Robin, Princess Celestia and Akari. Commercials show that some of the Skylanders are Kakashi, Marty McFly, Bulkhead and Barney Stinson.
- Skylanders Giants: Harley takes vengeance back awakening ancient robots. New Skylanders join the team, like Batman and The Tick. Nappa is now Don George. Piccolo fears the clouds and Iron Will is a gladiator.
- Skylanders SWAP Force: Don George goes to Cloudbreak Islands and meets Sam. The Skylanders fight Harley and his mother Pinako. Some of the new Skylanders are Sanji, Garp, Cheerilee, Babs Seed and Cole MacGrath.
- Skylanders Trap Team: Harley frees the villain team known as the Doom Raiders, formed by Patrick Star, Terrorsaur, Waspinator, Blondie Lockes, Miles Edgeworth, Magnum, P.I. and the Golden Queen, along with tons of villains, so the Skylanders have to trap them.
- Sonic Generations: Bumblebee is about to have his birthday party, when he gets sucked into a time loop with his friends Bianca, Raphael, Carnage, Cheerilee, Stan and others by Clank, also meeting him and Bianca's past selves.
- South Park: The Fractured but Whole: Shun Kazami, Mrs. Loud, Pimpa, Adam Spitz, Philip McAdams, Rookie Blue, and Jibanyan pretend to be superheroes.
- Transformers: War for Cybertron: Terrorsaur commands an army of Decepticons, including Brawl, Barricade, Jak, Marshall, Skywarp, Thundercracker, Breakdown, Trypticon, Shockwave, and Slipstream and they plot to defeat Zeta. Meanwhile, Batman leads the Autobots Chouji, Tokageroh, The Tick, Warpath, Gluttony, Silverbolt, Tristan Taylor, and Gin and Vodka.
- Watch_Dogs: After his niece is accidentally killed by Chief Quimby, professional hacker Ollie seeks his revenge with his trusty smartphone.