Makai Kingdom: Kyon, the most badass overlord in the Netherworld, destroys it when he gets enraged by Rei Ayanami insulting him through the Sacred Tome. In order to get his body back after confining his soul to the Tome and pushing out Mithos Yggdrasil in the process, he has to take over Rei's netherworld, along with those of such other Netherworld luminaries as Vulcanus, Iron Tager and Axel.
From Legion's universe: Ken's twin brother Eric Myers, photojournalist Dark Specter, ninja Brad Garrison, and lawyer Donatello. There's also a mutant zombie who's crossed paths with Shinji and Anemone and a gargoyle who's crossed paths with Gadved.
Mugen Souls: Bloody Marie, a tiny tyrant overlord, declares her plans to conquer seven rainbow-colored worlds by turning all of its inhabitants into bunny people. Aiding her in her quest are Almaz, her fiercely loyal but easily-flustered vassal, and Rakka, an angel who desperately wants to be a demon. Joker is a noble village guardian.
Mugen Souls Z: Thanks to a mishap involving a cursed coffin, Marie becomes even tinier, leaving her to ride around atop the head of dimwitted heroine Lucy Heartfilia as they quest to undo the effects with the help of Lucy's more intelligent companion Ami Onuki.
NieR (Gestalt version): In order to save his daughter Amy Sorel, Warpath acquires the power of the dark book of Gaara. He is challenged and later assisted by hot-tempered swordswoman Raspberyl.
NieR: Automata: Eight thousand years later, Earth is being invaded by aliens using "machine lifeforms" they control. Androids are built and dispatched to combat those machines. Umi Sonoda and Mikazuki Augus are some of these androids. Legion is Umi's support unit, and Asuna is a prototype to both Umi and Mikazuki.
Overwatch: Chrom is a 21st-century cowboy who would like to tell you that IT'S HIGH NOON. Flynn is a Swedish dwarf who builds turrets. Alucard is a gorilla from the moon in charge of bringing a multinational group of heroes back together. Guile is a B-movie director who wants you to move the damn payload already, and Lord Hater is Death himself.
Pepsiman: Paul is a superhero who does nothing but chug on Pepsi.
Persona 4: Arena: Shortly after the events of Persona 4, Lelouch, Ben, Polka (replacing Kitty Pryde), Rally, Pain and Leia are once again drawn into the TV world, this time to discover the dark secret behind a fighting tournament. Maka is now the color commentator, and Shiro Emiya (replacing Kakashi) appears to be goading them on. Meanwhile, Caster and Illidan also enter the TV world in search of Misha's sister, a robot named Kukaku Shiba who thinks she's human.
Phantom Brave: Melody is a girl who lives on an island and is rejected by society at large because of her ability to see spirits. Her only friend is a dead boy named Ecliptor. During a couple of jobs, they run into Orochimaru, who is trying to take their reward so he can support his sister Kari.
Prinny 2: Dawn of Operation Panties, Dood: The 1000 Teddies have reincarnated and have been replaced by 1000 Warriors of Light who are tasked with finding Rukia's missing panties. Meanwhile, Yoruichi tries to fight her way through look-a-likes to be a main character, especially her Evil CounterpartPascal.
Resident Evil 6: The fight against zombies and global bio-terrorism continues fifteen years after the Raccoon City Incident. Shinji partners with the Mystery Pill Guy to investigate an outbreak in China; Alvin (standing in for Specter) partners with Cheria Barnes to investigate an outbreak in Tall Oaks that infected the President himself; and Joel, a mercenary, partners with Bianca Montgomery (standing in for Paula). Jack (standing in for Annette) becomes heavily involved in the stories of the three aforementioned pairs.
Saints Row 2: An unnamed person wakes up from a coma that they were put into by being on a boat with Dr. Neo Cortex that was blown up by Dr. Facilier. The unnamed person saves their friend Jin Sun Kwon from going to prison, then soon starts up a new group of Saints consisting of Rubi Malone and an actor in Dominos Pizza commercials. They also have to rid the city of three gangs consisting of:
Shantae (series): Ying is a half-human, half-genie charged with defending a town from the constant raids of pirate queen Cerebella.
Shin Megami Tensei IV: Mondo Ohwada is a new samurai from the eastern kingdom of Mikado which, alongside Kellam, Alvin and Marie who travels in Naraku. He is accompanied by his AI partner, Palutena and can have contact with demons. After Temari has corrupt Kirito's best friend, Makoto Naegi he and his friends are ordered by Batou and Uryu Ishida to find Temari in the depths of Naraku who is, in actuality Tokyo. Eventually, Kirito has to choose between joining Kellam in a crusade against Lucifer who took human form as Tsubaki Yayoi, Alvin to fight god and Claves or assist Marie, Lu Bu and Miles Edgeworth to fight both Kellam and Alvin to make sure mankind is safe.
Skullgirls: Several girls compete for possession of the Skull Heart, an artifact which can bestow wishes on the victor but could potentially cost her soul. The combatants are Madoka Kaname, Homura Akemi and Sayaka Miki, respectively an amnesiac schooligirl who fights with the help of Ragna the Bloodedge (a parasite that forms Prehensile Hair), a circus performer in the employ of the mafia whose weapon is a hat with two giant muscular arms and a young girl with a damaged psyche who has been experimented to effectively become a living cartoon, Noire, a Princess with a napalm-tossing umbrella and a unit of crack troops at her command, Chi-Chi, a catwoman with an undying body whose attacks involve throwing her head at her enemies, Pre-rework!Karma and Ahri, respectively a Child Soldier who has been tortured and mindraped into being a Living Weapon and the psychotic nurse who did the experiments on the former, and an Eldritch Abomination. DLC characters so far include the undead opera singer Litchi Faye-Ling and her benevolent parasite Kain Highwind, the Game Trailers countdown guy who received an iron lung and assortment of musical instrument-shaped weaponry to take back his policeman job, Madoka Kaname's sinister dream-clone and the Egyptian-themed lounge singer Crimson Viper who secretly harbours a Lovecraftian Superpower that uses her own blood, a god complex and a psychotic parasite BlackRose who lives inside her skin. Chi-Chi also appears as robotic double of herself, despite being the same person.
Super Street Fighter IV: Cagliostro enlists Sasha to test a dangerous new weapon, and Klaus likes to wrestle with copious amounts of oil.
Ultra Street Fighter IV: The above cast is joined by a clone of Winry, peppy African dancer Sheva, pro wrestler Franky, his manager Kallen Kouzuki, and the mercenary Cell (the last three of whom once belonged to the same gang).
Street Fighter V: With his body failing, Exdeath makes one last attempt to take Kamina's body to keep himself alive, with his newest, poison-wielding lieutenant Makube on board and Squall and Shao Kahn back in the fold. Meanwhile, on the orders of Groribas, Kushina Uzumaki ressurects Jean Havoc and sends him on a mission with Sasha to stop Exdeath. Kasumi organizes her own cadre of fighters to stop Exdeath's plans including Dante, Rise, Zetsu, Winry, Grimmjow, ninja Tsuruhime, wrestlers Golbez and Shiko Sojin and Kasumi's layabout servant Craig Marduk. Elsewhere, Emirati prince Space Dandy is searching for his missing friend Ursula, Brazilian fighter Felicia looks to promote her family's jiu-jitsu style, Exdeath clone Kan-Ra looks for a new purpose in life along with Ayumi Otosaka, Ren Amamiya's car goes missing, Egyptian fortune teller Eli Ayase warns the fighters of their changing fates, Berg Katze ponders how to continue his ninjitsu teachings, and all the while Humanoid AbominationMason searches for strong fighters' souls to consume. Tohko, Kasumi's Friendly Rival, now works part-time at an arcade, Superman is the self-proclaimed "President of Earth" on a mission to unity humanity as one, Kallen is on the lookout for new wrestlers to manager after a falling-out with Franky, ex-con Tundra Man takes over for Roadhog as mayor of Metro City, and Norman is the fiery police officer working for both of them.
Super Smash Bros.: Nintendo's major characters get together and fight, as seen in the imagination of a gaming fan as he plays with his figurines. The fighters are Orvus and Gouji Rokkaku, the superstar hero brothers of the Mushroom Kingdom; Carne, an anthropomorphic fox space pilot; Witchell, a cute alien that can copy other people's powers; Joe Higashi, the hero of Hyrule; Tony Tony Chopper, an electrically-charged mouse; Professor E. Gadd, a dinosaur who helps Orvus and Gouji; Vegeta, a race car driver with an explosive punch; Jessie, another puffball from the same universe as Chopper; Viridi, a pint-sized psychic; a space bounty hunter and the ape king of the jungle. * Samus and Donkey Kong are The Voiceless in this game. At the end of the game's 1P mode, the fighters face off against Shaft, who also serves as the game's announcer.
Super Smash Bros. Brawl: New fighters this time are Ghetsis, an aura-sensing creature; Ivy Valentine, another psychic child in the mould of Viridi; Nancy Drew, an spunky angel boy; Alisa Bosconovitch, a Trainer of beings like Chopper, Nina and Ghetsis who in this game gives fighting directions to the water-based turtle Misty, the plant-like sauropod Tracey Sketchit and the fire-breathing dragon Roy Mustang; Minoshia, a toony version of Joe Higashi (who has become Austria); Paarthurnax, Orvus' greedy rival with a garlic obsession; Carmelita Fox, a Fragile Speedster version of the space bounty hunter regular; the game's developer, the hammer-wielding penguin king of Dream Land; Orion Tsang, a masked swordsman rival/antagonist of Witchell; Captain America, a secret agent; Usopp, the fastest hedgehog alive; a household robot; a freight company captain and his army of cute plant-like creatures; a mercenary hero wielding a giant broadsword; Caiman, an anthropomorphic wolf who pilots a spacecraft and is Carne's arch-rival; and a monkey friend and companion of the jungle ape who's been in the series since day one. * Jason Adkins (Ike) has no other known credits, while R.O.B., Olimar, and Diddy Kong are The Voiceless in this game. Meanwhile, Carne has become James McCloud, Sideswipe has become Pablo Sanchez, Patrick has become Tingle and Cortana has become Toadette. Additionally, Buff (alongside his destructive counterpart) are now Chet Brinkow.
Super Smash Bros. 4: New fighters this time around are Burgh, a water-infused frog ninja; Phoenix Wright, a boxer from Brooklyn; T. Hawk, a military tactician armed with several magical items (also playable as his female counterpart, Squigly); Chun-Li, Zelgadis Greywords' far descendant; Sequin, the Goddess of Light that Nancy Drew (who is now Ekko) serves; the Human Torch, Ekko's dark counterpart; Gohan, a wandering martial artist; Anders, the wielder of the future-predicting Monado; Trish, an exercise coach (also playable as her male counterpart, Deko Gekisho who is also Freddy, depending on your localisation); Zorin Blitz, a sexy time-bending witch; Leonardo, a prince armed with a mythic sword who can also turn into a dragon (also playable as his female counterpart, Lamb); X, a blonde-haired mercenary who wields a large sword; the dragon's son who is also playable as his former siblings (which include Bubsy, Rouge the Bat, Boom-Boom, and Pom-Pom); a mysterious space-faring princess; a hunting dog and his duck companion; a blue robotic warrior; a round ghost-eating fellow and a countryside villager. * Caety Sagoian (Bowser Jr.) and Kerri Kane (Rosalina) have no other known credits, while Duck Hunt, Mega Man, Pac-Man, and Villager are The Voiceless. Meanwhile, Jack Skellington has become Axel, Ghetsis has become Goku, and Usopp has become Chris Redfield. James McCloud and Pablo have changed again to become a different version of James McCloud and Achmed Khan, respectively. Finally, Chet Brinkow is now Grøh.
Tales of Berseria: Sakura Matou was an ordinary village girl whose world was afflicted with a mysterious disease that turned humans into demons. Even then, she led a relatively peaceful life until it was shattered one day when her brother-in-law Vlad III murdered her younger brother Fou as a ritual sacrifice. In the process, she was turned into a demon as well and was hauled to an island prison. For three years, her rage towards Vlad only grew, and when she was freed by the mysterious Abe no Seimei she immediately embarked on a quest for revenge against him, who was by then revered by the world for halting the demonblight. Along her journey, she attracted a ragtag bunch of allies with varying agendas, starting with the demon swordsman Darnic Yddgmillennia, and self-proclaimed witch Mordred followed by Sword, Faye, and Mash Kyrielight.
Tales of Graces: Zidane Tribal is the eldest son of a feudal family who has made a friendship pact with Ritsu Tainaka and CFW Brave when he was a kid. But life takes a harsh turn for him when Ritsu sacrificed herself to save him, prompting him to become a knight who swears to protect everyone. With additional companions like childhood friend Serah Farron, mentor Duke Pantarei, younger brother Jay, and quirky genius Fuka Kazamatsuri, he sets out on a journey to discover who Ritsu really is and to find out the reason for Brave's complete change in attitude.
Underground: The player character (who is either Null or Ginger Foutley) is an aspiring skateboarder from New Jersey whose best friend is Numbuh One. They sign up for a skateboarding competition sponsored by Stacey Peralta and get to meet Hush as well as their team's lazy fat manager Kakashi.
Underground 2: The player character (still Null or Ginger; with Yuj, Jazz and Nancy Drew as other voice options) goes on a world tour with Hush, half the cast of Jackass, Kiyo Takamine, Numbuh One, and some other pro skaters. The group is frequently pestered during the trip by a British TV producer named Eugene Horowitz. And for some reason, Almighty Tallest Red is every secret character.
American Wasteland: Lion-O is an aspiring skateboarder who moves to Los Angeles, where he meets Foxxy Love and her friends, who plan to reopen an abandoned skate park in Beverly Hills.
Trinity Universe: To stop space debris from destroying his planet, demon god Donatello and his loyal retainer Sakura go on adventures to knock these objects out of orbit. The duo frequently crosses paths with space valkyrie Rachel Alucard and dark hero Jack Russell, who believe the only way to save the universe is to confine Donatello inside a crystal for all eternity. Among the others involved in the conflict are would-be universal conqueror Rukia and her slave penguin Mid-Boss, angel-turned-witch Marona, creepy ghost girl Meryl Strife, snow cat-girl Orihime, and hot-headed treasure hunter Kimimaro.
Viewtiful Joe: While enjoying a flick at a movie theater with his girlfriend MOMO, Captain Rex watches in horror as the villain of the superhero movie they're watching drags MOMO into the movie. Rex is also brought to Movieland and taken under the wing of Grimlock, who teaches him how to control the special effects of a movie to use to his advantage. In order to win back his girlfriend and return home, Rex must face Superman, Captain Gantu, Michelangelo, and Grimlock himself.
Viewtiful Joe 2: Having saved MOMO, Rex and his newly Henshin'd girlfriend are sent out on another adventure by Grimlock, one that's quickly intercepted by the coming of the newest evil syndicate invading Movieworld. This time, however, Rex gets some help on the other side of the silver screen from his father Gilgamesh. Together, Rex and MOMO must now face Osmund Saddler, Doctor Strange, Teddie, Mikey (again), Kakuzu, Black Canary, and Al-Mualim to make their way to the baddies' leader. Turns out that Gilgamesh is said leader, albeit corrupted by an Artifact of Doom that preyed on his desires to be the ultimate hero for his son Rex.
Viewtiful Joe: Double Trouble: Rex is forced to team up with his bratty younger sisterViridi in order to recover Grimlock's latest film, in which Viridi starred. Along the way, the siblings discover that the evil organization this time is led by their deceased mother, Breach, who came back from heaven for a day to test her children to see how much they've grown. Oh, and Mikey shows up yet again to challenge Rex to a fight. He ends up Taking The Giant Fist from Breach for Rex because he's the only one allowed to defeat him.
The Walking Dead: Rodin is an escaped convict who is caught in the middle of a zombie apocalypse. He finds and takes care of a little kid named Komasan, who was left all alone after his parents go missing.
Xenoblade Chronicles 2: Rex's Titan friend Gramps is voiced by Sean Barrett, who is quite clearly using his Andre of Astora voice. When Gramps is nearly killed and regenerates early in the game, he reverts to a much younger Titan form, with a younger voice to match. Now he sounds like Sean Barrett's other Dark Souls role, Petrus of Thorolund.
Zettai Hero Project: You watch Kamina die, and have to finish his fight against Dist...which you lose horribly. Now, you have to go through Training from Hell set up by Kamina and would-be heroine Tails until you become strong enough to face off against Dist one last time and save the world.