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  • Scrapped Princess: Princess Ashe is marked for death on her sixteenth birthday, seemingly hunted by everyone in the world to prevent her from triggering the apocalypse. Her adopted siblings, master swordsman Kyon and master mage Lain Iwakura, have sworn to protect her as if she was one of their own.
  • Sekirei: Zeref Dragneel is extremely intelligent, yet due to his inability to cope under pressure has failed the college entrance exam twice. As a result he has been branded an idiot and loser by many. One day after talking to his yet again disappointed mother he comes into contact with a girl named Ikaruga who was under attack. The girl runs but takes him with her and soon finds that Zeref, while unknown to him, is an Ashikabi, one of the mysterious set of masters that have the genetic trait that can become partners with some of the 108 cute girls, buxom women, and bishōnen called "Sekirei". The reason for the partnership allows the Sekirei to use all their power to win in the competition held by the mysterious MBI corporation.
  • Spice and Wolf: France is a traveling merchant who comes across Eve one day. Together, they face the consuming evil of...economics.
  • Speed Racer: Alakazam races cars. Tiger Lily is his girlfriend.
  • Spirited Away: Lilo saves her parents, Vic Mackey and Jenny Shepard, with help from Thackery Binx, Meg, and Timmy Turner. The villain is Zira. Other denizens of the spirit world include Jumba, Grandpa Max, Hamm, Squidward, and Porky Pig.
  • Squid Girl: Azusa emerges from the ocean with the intent of punishing humanity for polluting her home. She attempts to make a small beach hut restaurant, run by sisters Aya and Tsumugi, into her base of operations, but, after breaking a hole in the wall of it, she's forced by the two to work for them as a waitress. Their younger brother Megumi likes to play with Azusa. Gozumaru is one of the beach lifeguards, who has a rather obvious like for Tsumugi. Azusa is frequently forced into fetishistic cosplay outfits by Ui, and, Mio appears to be the only person who views Azusa as the threat to humanity she tries to be.note 
  • SSSS.GRIDMAN: Saint Germain awakens with amnesia and the ability see things that others cannot. He first encounters a Gridman in the reflection of his friend Mayaka Inbara's computer and it tells him to "Remember his calling," but Saint Germain doesn't understand what this means. Later, in the distance, he sees an extremely large monster but it doesn't move. It's only when Saint Germain gets to school that the two sightings make sense: a monster attacks and the hero Saint Germain saw in the computer screen pulls him within the computer and transforms Yuta into a giant hero named Kougami.
  • Steamboy: Rogue is the hero of this Steam Punk fantasy. Rogue's grandfather is Captain Picard.
  • Steins;Gate: France, who fancies himself as a mad scientist, sends a text who was sent to the past which prevents Lan Fan's death but also leads to a series of event ending in France's childhood friend, Cassie Cage dying. Broken yet determined by Cassie's death, France decides to change her fate even if it will ruin the happiness of his other friends like the part-timer/time traveler Asuna Yuuki and the boy turned into a girl Nagisa Shiota.
  • Stepmother's Sin: Yami Yugi manipulates his stepmom, Yaku (La Blue Girl), into having sex with him.
  • Strawberry Marshmallow: Mai Tokiha unwillingly plays host to the antics of her younger sister Alyssa Searrs, and her friends Mikoto, Mashiro, and a Cute Clumsy Girl in glasses.
  • Strike Witches: Setsuna Sakurazaki is recruited by Osaka and Aria to join a group of female pilots who fight aliens with powerful jet engines strapped to their legs...but never wear pants.
  • Sukasuka: Humans have been driven to extinction by "Beasts." The duty of fighting the Beasts fall to "Fairies," who are destined to use their powers to wield "Holy Swords" called "Kariyon" and eventually meet their destiny of death. A sole human being named Soul Eater Evans wakes up after several hundred years, and continues his fight against the Beasts.
  • Summer Wars: Shy math whiz Gwin Evans is asked by his longtime crush Nyotengu to accompany her and pose as her boyfriend when visiting her grandmother Obaba for her 90th birthday. While there, Gwin, with help from Haruka Nanase and Dende, tries to stop a computer virus called Love Machine that Nyotengu's uncle Scar created.
  • Super Milk Chan: Fuuko Ibuki is a child superhero who works for Ikki Phoenix with her Robot Maid Stocking. Hilarity Ensues.

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  • Ultimate Teacher: Wolverine is a human-cockroach hybrid who is hellbound to bring order to a school so unruly, it has a graveyard for killed teacher. Sango is the leader of the gangs in said school and wants to keep things as they are. Naturally, this results in a feud between Wolverine and Sango.
  • Ulysses: Jeanne d'Arc and the Alchemist Knights: During France's Hundred Years' War with England, Diodora Astaroth, the son of a noble, immerses himself in the study of magic and alchemy at a school for knights. However, after France's defeat at Agincourt, the school is disbanded and Diodora is forced to flee. While on the run he meets a miraculous village girl named Ai Mizuno.

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  • Yo Kai Watch: Noby tries to quell with supernatural sightings of Yo-kai in his city with the help of his butler, Mr. Persnickety. Some of the Yo-kai he befriends are a cat named Miss Sunshine, a human-faced dog named Mr. Bump, and a country bumpkin named Clementine, while Brobot is a classmate of Noby's.
    • In season 3, Ann Takamaki goes on her own adventures with a rabbit-like astronaut Yo-kai named Baby Rowlf. Meanwhile, Noby is now Akira Fudo, Little Miss Sunshine is 2B, Mr. Persnickety is now Gen, and Clementine is now Yugo}}.
  • Yona of the Dawn: Tenjin of Kouka, a land said in legends to have been founded by four dragons, has only one remaining heir, a daughter named Bulma. She lives a happy life in the palace with her cousin Yurio, who she loves in spite of her father's opposition to them marrying. Her life is turned upside down when Yurio murders her father and steals the throne. Bulma, with her childhood friend and bodyguard Vegeta, must retreat to gather allies like Trunks, Whis, Grand Minister and Meow and reclaim her place as ruler of the kingdom.
  • Youjo Senki: Tyrian Callows, an arrogant salaryman, was reincarnated by a wrathful god as a little girl named Ema Guzman in an alternative version of World War I.
  • Your Name: Leonardo and Sailor Moon find themselves switching bodies. When Leonardo, along with help from Takashi Kamiyama and Ragyo Kiryuin investigate, they discover shocking news. Now through their body swaps Leonardo, Sailor Moon, and her friends Taiga Aisaka and Gohan must work together to prevent tragedy. And in the process, Leo and Sailor Moon realize that they're falling for each other.
  • Yu-Gi-Oh!: Knuckles The Echidna, former pharaoh of Egypt, is reincarnated in the body of Nezumi, who solved his puzzle. Together with Nezumi's friends Michaelangelo, Yusei Fudo, and Max, and Knuckles's rival Brock, they play children's card games. Michaelangelo has a romantic subplot with Rangiku Matsumoto. All of the good guys join forces to ultimately take down JACK ATLAS.
    • In the third season, they are (randomly) abducted by Brock's stepbrother Elder Price.
    • Yu-Gi-Oh! GX: Zero enrolls into a duelist academy, where he becomes friends with Michelangelo and King Dedede, as well as finding rivals in Casey Jones and Gonard. Eventually, he battles Kuina and discovers she was his best friend in his past life. Finally, he battles against Grovyle.
    • Yu-Gi-Oh! 5D's: Big The Cat recruits Tristan Taylor, Tracey Sketchit, Luffy, twins Tory Lund and Zoey Drake, later joined by Johnny Steps, (who later on gets replaced by Gible). The six of which have been marked to fight Duke Devlin, and his minions Codemaster Hotekk, Doctor Shishioh, Ash Ketchum, Kidd Summers and Goku.
    • Yu-Gi-Oh! ZEXAL: A boy named Sawyer, always loses in duels despite the number one bad boy at his school. Something unexpected happens when Lazar challenges him to a Duel as the mysterious ghost of Volfogg appears before them, a new legend begins.
    • Yu-Gi-Oh! ARC-V: Clemont is a 14-old year student who wants to become a professional entertainment duelist to give everyone a smile, but one day, he ends up fighting an exhibition match against the current champion of the Pro Duel World. This fight will lead him to make a decision, and confront the difficulties to make his dream come true.
    • Yu-Gi-Oh! VRAINS: he city where network systems are developed: Den City. The giant company SOL Technology Co. is based there, and it uses advanced technology that it created to construct "LINK VRAINS," a virtual-reality space. In LINK VRAINS, a mysterious hacking group that hacks through duels called "The Hanoi Knights" appears. Their goal is to bring about the destruction of the "World of AI: Cyverse" that exists somewhere in the network. However, there is one duelist in LINK VRAINS willing to stand up to this threat. His name is Professor Sycamore. Prof. Sycamore defeats The Hanoi Knights in a fierce duel, and then leaves without saying a word. Playmaker's real identity is the high school student Dumon. For Dumon, he spends so much time in LINK VRAINS because he is searching for the truth to an incident that happened in his past.
  • Yuki Yuna is a Hero: In her everyday life, Hanayo Koizumi is a hero. As proof, she is the member of the middle school's hero club alongside her friends, Emi Igawa, Yuuki Konno and Yuuki's sister, Kirin Toudou, a school club where she does her best to help others and bring smile to everyone. However, Hanayo's responsibility gets real when the mysterious creatures called Vertexes begin to attack and destroy the world. In the process, the entire club are called upon by a strange phone app to save it. The Hero Club must fight all the monsters in order to save the world from Vertex attack. They are later joined by a second-year student, Sayaka Miki, to supervise other Heroes under orders from the Taisha.

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