Anime and Manga
- Godzilla: Singular Point: The "The Tyger" poem is discussed in Episode 6, while solving the meaning of "fearful symmetry" from Professor Ashihara's notes regarding space-time.
- From Hell reveals that his famous portrait of a monster "The Ghost of a Flea" was actually a portrait of the ghost of Sir William Gull, aka Jack the Ripper. Earlier in the novel, Gull visits his grave and explains the mystical significance of his works to his sidekick, Netley.
- In the Spider-Man story Kraven's Last Hunt, quotations from "The Tyger" are spread all throughout the storyline with "tyger" replaced by "spider".
- The Punisher MAX: The one-shot "The Tyger" depicts the child Frank Castle studying Blake's poem at school, with strong comparisons between Blake's terrifying tiger and the person Frank will grow up to be.
- In the 1831 AD one-shot of The Wicked + The Divine, one of the early-nineteenth-century Pantheon members who is already dead when the issue starts, the Angel of Soho, is clearly analogous to Blake.
Film - Live Action
- Bull Durham: When Annie storms into Crash's apartment and accuses him of trying to keep her from sleeping with Nuke, he interrupts her by comment on how excessive her dress is, at which point she quotes "The Marriage of Heaven and Hell": "The road to excess leads to the palace of wisdom."Crash: Wh — William Blake?
Annie: William Blake.
Crash: Wi-William Blake?!
Annie: William Blake!
Crash: What do you mean, William Blake?
Annie: I MEAN, WILLIAM BLAKE!
- One of the protagonists of Dead Man is a Blake fan, and quotes him extensively. The other is named William Blake, but otherwise has no connection to the poet.
- Cold Days: Thomas's "The path of excess leads to the palace of wisdom" paraphrases William Blake.
- Bill "Taleswapper" Blake is a major supporting character in the alternate history series The Tales of Alvin Maker.
- William Blake is a supporting character in the Doctor Who New Adventures novel The Pit.
- The Tyger provides the epigraphs to each section of 1632.
- Revenge quotes his famous Infinite/Perception statement in the episode "Perception".
- The Mentalist: The Big Bad, Red John, is a big fan of Blake's poems, as well as his close accomplices, The Blake Association.
- Bruce Dickinson's album The Chemical Wedding derives inspiration from Blake's paintings and poetry, using Blake's painting The Ghost of a Flea as the album's artwork.
- Ulver set all of The Marriage of Heaven and Hell to music for their fourth album, resulting in Epic Rocking to the extreme.
- Neo Yokio makes several references to the works of Blake. The national anthem of the eponymous city state is the hymn Jerusalem with the word "England" changed to "Neo". In a later episode a character enters the Tiger Bar by giving the password "fearful symmetry" from The Tyger.
- The premier trailer for Death Stranding opened with a quote from Auguries of Innocence.To see a world in a grain of sand
And a Heaven in a wild flower
Hold Infinity in the palm of your hand
And Eternity in an hour
- Devil May Cry 5 is a full-on homage to the works of William Blake, as they play a major central theme in the context of both the story and the game's development.
'He who desires but act not breeds pestilence'... so it is written.
- Playable character V, in particular, is notable for speaking almost entirely in William Blake poetry. In his reveal trailer, he quotes a line from The Marriage of Heaven and Hell.
- The villain of the game, Urizen, is also named after a major character in William Blake's works. And he very fittingly acts a lot like the character he is named after.