- Among Us
- Angry Birds
- Animal Crossing
- Battletoads
- Call of Duty
- Commander Keen
- Conway's Game of Life
- Crash Bandicoot
- Crysis
- Cuphead
- Dark Souls
- Dead Space
- Devil May Cry
- Donkey Kong
- Doom
- Dragon Quest
- Dragon's Lair
- Earthworm Jim
- The Elder Scrolls V: Skyrim
- Fallout
- Final Fantasy
- Five Nights at Freddy's
- Fortnite
- Frogger
- Grand Theft Auto
- Guilty Gear
- Henry Stickmin Series
- Jak and Daxter
- Kingdom Hearts
- Kirby
- The Legend of Zelda
- Life Is Strange
- MacVenture
- Marble Madness
- Mass Effect
- Metroid
- Minecraft
- Monkey Island
- Mortal Kombat
- OFF
- Pac-Man
- Papers, Please
- Parappa The Rapper
- Plants vs. Zombies
- Pokémon
- Polybius
- Pong
- Portal
- Punch-Out!!
- Quake
- Ratchet & Clank
- Roblox
- Sid Meier's Alpha Centauri
- Sly Cooper
- Sonic the Hedgehog
- Space Invaders
- Street Fighter
- Super Mario Bros.
- Super Smash Bros.
- Tamagotchi
- Tetris
- Tomb Raider
- Touhou Project
- TwinBee
- Undertale
- Unreal
- World of Warcraft
- Zero Wing
Systems
- Ace Attorney:
- In episode two of the Netflix documentary High Score, a pixel-art dramatization of the infamous Universal vs. Nintendo case over whether Donkey Kong was a copyright infringement over King Kong appropriately has Nintendo's lawyer John Kirby pointing during the trial, including a replica of the rushing blue background.
- Lil Gator Game has the title character's confrontation with Duke the duck being staged as a typical Ace Attorney trial, complete with reaction shots, with fellow friend Martin called in as a witness.
- Altered Beast (1988):
- To promote their fourth album, Dear Agony, Breaking Benjamin released a flash game on their website based on Altered Beast called Altered Benjamin, starring the lead singer as the player character. It can be played here.
- Matthew Sweet named his fourth album Altered Beast after the game. A live EP of his is also called Son of Altered Beast.
- The Angry Video Game Nerd: In "How the Nerd Stole Christmas", the Nerd calls the Sega Genesis port of Altered Beast "A nut-kicking feast I can't stand in the least."
- MF217 tends to prefer referencing the black sheep of the franchise known as "Project Altered Beast", because he personally believes with the right amount of polish and more effort put into the concept, he feels like it's perhaps the best course of action as to how to modernize the concept of a shapeshifting focused beat-em up even if it's not true to the roots of the series. One of his OC's, Mirror M, has a damaged eye which even in spite of the immense Healing Factor Mirror M has, it'll never heal, which is the same deal regarding a scar that the main character of this game has across his chest because of his rival having wounded him with a neurotoxin based claw swipe.
- Amnesia: The Dark Descent: SCP Foundation: SCP-2786 is a metaphysical entity that can insert itself into horror narratives, where it attempts to portray itself as a brave hero and alter the story itself. One of these is listed as the videogame Amnesia: The Dark Descent.
- Antimatter Dimensions:
- Escape from Vantablack: One of the title screen messages mentions that the dimensions here are not made of antimatter.
- Prestige Tree Rewritten: The achievement system uses images for each achievement in a similar manner to this game.
- Synergism: The :antismith: code is stated to be a reference to this game.
- Assassin's Creed:
- The French edutainment Confession Cam parody web-series Confessions d'Histoire has an episode about the First Crusade in which a Hashshashin shows up. His attire is inspired by, of course, Altaïr ibn-La'Ahad.
- In The Other Boy, Shane's dad has an advance copy of the latest Assassin's Creed game. He offers to get Shane a copy, but Shane's mom doesn't have an Xbox.
- Bastion: Transistor: Red has toys referencing the Supergiant Games' previous game: A Windbag and a Cael Hammer in her apartment.
- Beneath a Steel Sky:
- Broken Sword II: The Smoking Mirror: If Nico Collard tries to give a chocolate to a ghost, Robert Foster shows up in a tunnel.
- Candy Crush Saga: In The Many Mysteries of the Finkel Family, Caroline mostly uses her tablet to play Candy Crush when she's not using it for communication. She's up to level 457.
- Clash at Demonhead:
- In Scott Pilgrim, one of Ramona's evil exes is the bassist for a band called "The Clash at Demonhead" (which references both this game and the band The Clash). The band's drummer, Lynette Guycot, is named after Tom Guycot, a skeleton NPC you meet early in the game.
- OK K.O.! Let's Be Heroes has a character named A Real Magic Skeleton, a Friendly Skeleton who looks just like Tom Guycot, right down to the red cape.
- Downwell:
- Tower Fortress is said to be directly inspired by Downwell. In fact, one of the main character's suits, the Downwell suit, stylizes the game into the style of Downwell.
- Guild Wars: In The Boy from Aleppo Who Painted the War, Adam's Only Friend Nabil sometimes invites him over to play Guild Wars.
- Guilty Gear Xrd:
- The first episode of Gamers! (2015): At the gaming club itself, Niina is playing Guilty Gear Xrd Rev 2, but most of the time is spent in a multi-player First-Person Shooter with a very strong resemblance to Counter-Strike. The club also has Xrd Rev 2 posters up on the walls.
- Them's Fightin' Herds: Players who own Guilty Gear Xrd REV 2 can unlock lobby items that can make their avatar look like Sol Badguy/Ky Kiske.
- Gone Home:
- Tacoma: The Christmas Duck can be found in one of the rooms.
- Hitman:
- One guard is named "Agent 47" in Detroit: Become Human.
- Metal Gear Solid V: The Phantom Pain has Ocelot refer to Quiet as "our Silent Assassin".
- Mutant: Year Zero has a perk called "Silent Assassin," which increases Critical Hit chances. The flavour text reads "Like the dome-headed assassins of the past, you are able to do great damage while hidden from your target. That's as long as you hit... Man."
- Kid Icarus: Uprising: What Your Favourite Cure Says About You claims that fans of Kid Icarus Uprising are most likely to select Cure Earth to be their favourite Pretty Cure.
- Lennus: From A Very Long Rope to the Top of the Sky: The Developer's Note for the song "Royalty":This song was pretty heavily inspired by the music from the Lennus series.
I also attribute my overuse of the glockenspiel to the Lennus series (though there is no glockenspiel in this song). - Madden NFL:
- The direct to streaming film "Fantasy Football" is about the daughter of a fringe NFL player controlling him in real life using a magical copy of Madden 23.
- In Dogs Don't Talk, Ben has a dream about playing the game with Johnny.
- On The Good Place, Jason Mendoza is at one point challenged with beating the Tennessee Titans with his beloved Jacksonville Jaguars. He is unable to do so. Much later, him playing the "perfect game" of Madden convinces him that he has achieved everything that he's ever wanted, convincing him to walk through the final door.
- Scott The Woz is infatuated with Madden 08, possibly because it was the last game released for the Nintendo GameCube. It shows up constantly throughout his videos to the point where his 2017 Christmas Episode is called "A Very Madden 08 Christmas". Conversely, he's also shown some hostility towards Madden 09, the final game released for the original Xbox.
- Mafia II:
- MF217, during his co-op Let's Play video for Digimon World 4, notices that SkullGreymon's Oblivion Bird move could be interrupted by magic attacks from which his friend Cory did by accident but MF217 was quickly aware of how to deal with SkullGreymon. Among the things he said to get the point across during the fight was "Back me up Vito!".
- Metal Gear:
- Mobile Suit Gundam SEED and its sequel Mobile Suit Gundam SEED Destiny feature Mu La Flaga and his clone "brothers" (actually his fathers' clones) Rau Le Creuset and Rey Za Burrel, who are all heavily inspired by the sons of Big Boss.
- Mu, like Solid Snake, is the heroic "inferior son" of his father, and his Badass Boast/Catchphrase is even Solid's Red Baron ("The Man Who Can Make the Impossible, Possible"). In the sequel, Mu comes back with an alias two years after supposedly dying just like Solid did in Metal Gear Solid 2: Sons of Liberty.
- Rau, like Liquid Snake, is the nefarious long-haired son who resented his father and brother.
- Rey, like Solidus Snake, is the youngest known clone brother who doesn't share the first two's age (in Solidus' case, he appears much older whilst Rey appears his actual age) and is closely connected with the sword-wielding Contrasting Sequel Main Character (Rey being Shinn Asuka's teammate, Solidus being Raiden's adoptive father).
- The titular Wreck-It Ralph finds the iconic "!" pop-up when looking for a medal at Tapper.
- Mobile Suit Gundam SEED and its sequel Mobile Suit Gundam SEED Destiny feature Mu La Flaga and his clone "brothers" (actually his fathers' clones) Rau Le Creuset and Rey Za Burrel, who are all heavily inspired by the sons of Big Boss.
- Museum Madness:
- Linkara mentioned Museum Madness in his review of Chuck Norris Karate Kommandos #2:
Linkara: And really, when else is she gonna get the chance to play Museum Madness? Does anyone else remember that game? You had a robot...? You... went around fixing the museum exhibits after they went nuts...? I am such a nerd. - Myst:
- In The Simpsons, the library is seen in the third dimention during Homer³, and the music for the end credits and Gracie Films Vanity Plate are done in the style of the game.
- In Strong Bad's devlog for Strong Bad's Cool Game for Attractive People, he states he's playing Myst at one point, and pokes fun at its Port Overdosed status.
"I'm seeing who's taller, Strong Mad, or all the different versions of this freaking game stacked on top of each other." - The Neverhood is referenced by Paradigm: The glam nun has a tattoo of Klaymen on her arm.
- Prayer of the Faithless: Weird and Unfortunate Things Are Happening: A bit of graffiti says “Slayer Of The Faithless”.
- Secret Files: In a Take That! from Goodbye Deponia, Rufus is groping around in the dark and finds something "dry, long, and thin" which he jokingly identifies as "...the plot of Secret Files: Tunguska! Or a low-hanging branch. Either one."
- The Sims:
- Zoe from Social Queue loves The Sims, and spends hours playing it when she's overwhelmed. When she was younger, she had an entire Sims neighborhood for all her friends.
- An April Fools' Day episode of The Drew Carey Show had a scene filmed in The Sims.
- SiIvaGunner has a few Sims rips. For example, Buy Mode 1 from the first one is a mashup with Yung Gravy's "Richard Simmons", while the main theme of the third game fuses the usual SiIva memes together into a medley.
- Joel from Vinesauce often plays Sims games. Since this is Joel we're talking about, these sessions can get more than a little weird. See his highlight videos for Sims 3 and Sims 4.
- Space Quest:
- In the first EcoQuest game, Adam tells Delphineus, "The stalagmites go up. The stalactites go down. If you don't know that, you've never played a Space Quest."
- In the 2020 Homestar Runner cartoon "Halloween Hijinks", The Poopsmith dresses as one of the 2 Guys from Andromeda.
- The following year, in the Halloween game "Halloween Hide And Seek", Strong Bad dresses as Vohaul, drawing inspiration from the fan VGA remake of the second game.
- For April Fools' Day 2021, the Lost Media Wiki Discord server was turned into a Space Quest server. All channels were renamed, the LMW-tan bot became a Space Quest bot, and even the Question of the Day was about Space Quest.
- Splatterhouse:
- Bloodstained: Ritual of the Night: Dantalion's head has a bald, fleshy appearance making it resemble Hell Chaos.
- Night Ripper: One bit of graffiti you can find reads "BE GARBAGE OF CESSPOOL HAHA".
- Project × Zone: One of the items is the Terror Mask.
- Tales of Eternia: A cameo of Rick shows up in a bonus dungeon.
- Mappy: "The guy from Splatterhouse" stole someone's parking space.
- StarTropics:
- Animal Crossing: New Horizons: Gulliver compares the pleasant greeting he receives from your offer of aid to being marooned in the town of Coralcola.
- Zoda of the F-Zero franchise is a villain who has constantly tried to conquer Earth, although that is where the similarities end; while he looks appropriately alien, this Zoda Was Once a Man.
- Pilotwings 64 has Crescent Island as a location, its design basically being a 3D rendition of StarTropics' C-Island.
- Sunset Overdrive:
- The Conversion Bureau: The Other Side of the Spectrum: Light Despondent: Chapter 8: "Sunset City / God Bless Us Every One": The chapter's title is a double reference to Sunset Overdrive and A Christmas Carol.
- Hardcore Henry: The punk rocker Jimmy is dressed up the same as the punk gracing the cover.
- Crazy Ex-Girlfriend: Sunset Overdrive is the video game Josh Chan plays in an episode.
- Company Cross References: Ratchet & Clank: Rift Apart:
- The RYNO 8 can pull in an Overcharge barrel and Fizzie.
- A currency replacement cheat can replace it with cans of Overcharge.
- Inside the jukebox at Zurkie's are figurines of Sasquatch and Friends.
- Technician Ted:
- "Macaroni Ted" in the Amstrad and second Spectrum versions of Jet Set Willy is a Shout-Out / Take That! to this game.
- Tekken:
- A minor character in Beastars is a fighting kangaroo named Roger.
- Mokujin the sentient training dummy is inspired by the titular wooden automata from Shaolin Wooden Men.
- In Queens of Geek, Tekken is one of the games at the arcade where Alyssa takes Charlie.
- Crash Zone: Characters play Tekken 3 in the episode Dream Team.
- In one Strong Bad Email, Strong Bad reads "TN" (the postal code for Tennessee) as "Tekken."
- How to Ratatwang Your Panda from The Amazing World of Gumball features a panda whose "secret weapon" is his farts, similar to moves Panda and Kuma can perform.
- Transistor:
- League of Legends: Ekko's Classic skin references two Supergiant Games's games: The Kid of Bastion (note the red scarves, the hand wraps, and the utilitarian armour, as well as the white hair), while his weapon is reminiscent of the Transistor, with its green edges being similar color and glowy.
- In Supergiant Games's fourth game Hades, Christopher Saphire, voices Thanatos, and previously voiced Asher Kendrell, where they're both reserved, (mostly) unemotional character, Asher is in a loving relationship with Grant, who prioritizes duty and loyalty. Fortunately, Thanatos's story turns out a lot better than Asher's.
- Uncharted:
- Lea from The Good Doctor introduces herself to Shaun by asking to borrow batteries because her controller died while she was playing Uncharted.
- In the Community episode Advanced Dungeons And Dragons, a copy of Uncharted 2: Among Thieves is seen as one of Fat Neil's "Outlets Of Fantasy". Also counts as a company cross reference, as the series was produced by Sony Pictures Television, a division of Sony, which also makes the PlayStation brand, and thus, owns the Uncharted series.
- Whispered World: Chaos On Deponia: Returning through the teleporter in the second game's final act causes Rufus to briefly enter the Whispered World.