LEGO The Incredibles: Russel appears as an unlockable character, unlocked by building Carl's House in the Municiberg Financial District. Russel can summon Kevin, track clues, travel through crawl vents, and light campfires.
SuperMarioLogan: In "Jeffy Goes to Disney World!", Mario buys Jeffy some Up-themed Mickey Mouse ears at the gift shop.
Todd in the Shadows: Todd decides about ten seconds in that "I Took a Pill in Ibiza" by Mike Posner is the saddest song he's ever heard in his life. "Christ, the beginning of Up didn't make me this depressed!"
A sketch from "Saving Private Gigli" features Carl attempting to fly to Paradise Falls, only for the balloons carrying his house to break away, causing it to fall on some construction workers, killing them and getting Carl arrested as a result.
Carl: I won't last ten days in prison.
A sketch from "Musha Shakhtyorov in: Honeyboogers" has Gooey Louie watch the film on an airplane. Five minutes into the film, Louie tears up and wipes his nose on the tie of the germaphobic passenger next to him, much to the latter's ire.
The 2016 YA novel You Look Different in Real Life is about five youngsters who were filmed for a documentary when they were all six, with follow-ups chronicling how their lives have changed during five-year intervals. This is comparable to the premise of the Up films.