- A late-1990s Cartoon Network bumper (that often played before movie presentations) featured a bunch of monkeys (including Magilla Gorilla, Grape Ape and I. R. Baboon) gathering around the Cartoon Network logo while "Also sprach Zarathustra" plays.
- Cowboy Bebop has very strong references to the film in two episodes:
- "Jamming with Edward" features a very HAL-like AI in both mannerisms and design. Luckily, this AI is not as sinister in intentions as HAL.
- "Toys in the Attic" ends with Spike throwing the contaminated fridge into space. The crew then float around in the Bebop unconscious as "Waltz of the Flowers" plays and the ship flies on autopilot, a clear reference to the opening "Blue Danube Waltz" sequence in Odyssey.
- An odd parodic example in the recap episode of Samurai Champloo during a scene with Mugen verbally abusing a Monk. The use of music and the camera panning from behind the Monk's head invokes the famous opening sequence of the Sun rising above the Earth.
- The Mystery of Mamo has a shot near the end of the film (when Mamo's brain floats into the Sun) that homages the opening planet sequence of Odyssey.
- The Peanuts Movie: The film's teaser trailer starts out like this film, in which "Also sprach Zarathustra" plays while the sun rises over what appears to be a planet, but is really Charlie Brown's bald head.
- Robots: A delirious Bigweld sings a slowed-down rendition of "Daisy Bell" while Rodney tries to repair him.
- A Clockwork Orange: The soundtrack album for the film is displayed at the record store. Appropriately, this film is also directed by Stanley Kubrick.
- The 2005 Charlie and the Chocolate Factory adaptation uses the famous scene of the apes surrounding the Monolith and the "Also sprach Zarathustra" theme for the sequence in the TV teleportation room. Wonka amusingly replaces the Monolith for a chocolate bar in order to show his visitors how a TV can be used as a teleporter for Wonka chocolate.
- Parodied in Zoolander when Derek and Hansel struggle to work a computer. They begin acting like apes, slapping the computer and howling as the "Also sprach Zarathustra" theme kicks in. The scene ends with Hansel nearly smashing the computer with a bone.
- Save the Green Planet! has a sequence that closely follows the first scene, showing early humans being created next to an obelisk from space, and apelike humans howling and smashing bones.
- History of the World Part I opens with a parody of the "Dawn of Man" sequence.
- Woody Allen cast actor Douglas Rain (HAL) in an Uncredited Role as the voice of the controlling computer in the closing sequences of Sleeper.
- Airplane II: The Sequel features a computer called ROK 9000 in control of a Moon shuttle which malfunctions and kills crew members, which several reviewers found reminiscent of HAL.
- Ridley Scott cited the film as an influence on Alien, mostly in its depiction of life in space.
- One of the EVA pods can be seen in Watto's junkyard in Star Wars: The Phantom Menace. The reference book Star Wars: Complete Locations has some fun by identifying it as "a repair and maintenance pod of unknown origin."
- Isaac Asimov's Extraterrestrial Civilizations: References this work for the motif of aliens observing Earth's evolution from hominids to space travel.
- Married... with Children:
- In "The Computer Show", Al's talking computer says "What are you doing, Al?" as he is about to smash it.
- In "Children of the Corns", Peg and Kelly are amazed by a microwave oven and surround it as if it were the Monolith.
- On an episode of Monty Python's Flying Circus, Terry Gilliam, a big fan of Kubrick in general (and of 2001 in particular), provided an animated link between two sketches that was a parody of the opening credit sequence.
- Mystery Science Theater 3000 had the design of the Satellite of Love, based on the bone-shaped satellite featured in the match cut from prehistoria to the future. The one-eyed design of the robot Gypsy led the show to do various scenes comparing it to HAL, including a scene from the 1996 feature film, where the opening featuring Mike Nelson jogging along the walls of the Satellite of Love parodies the scene where Frank Poole does the same in the Discovery.
- Reba had Brock locked inside a car by the car's navigation system (because Brock warned it to stay away from Barbra Jean, whom the system was falling for) named "Al". After Brock demands Al to open the door...Al: I'm afraid I can't do that, Dave.
- Red Dwarf:
- The first two series' title music is very reminiscent of Also sprach Zarathustra, and the sequence is in line with scenes that use said music. The name Holly is a Shout-Out to 2001's HAL, too, as is the fact that Holly, or "Hol" as Lister sometimes calls him, refers to David Lister as "Dave." (In the radio sketch series Dave Hollins, Space Cadet on which the series is based, the computer was known as 'Hab'.) As is, eventually in Series VII, Holly says: I'm sorry, Dave. I'm afraid I can't do that.
- Holly singing as he gets erased in "Queeg" was inspired by HAL's death.
- The Bill Nye the Science Guy episode on the planets included an obligatory parody:Bill: Open the pod bay doors, HAL.
HAL: I'm sorry, Bill. I'm afraid I can't do that.
Bill: HAL. I need you to open the pod bay doors, HAL.
HAL: I'm afraid I can't do that, Bill. This show on the planets is too important for me to allow you to jeopardize it.
HAL: Goodbye, Bill.
Bill: HAL! C'MON, OPEN THE DOORS, WILL YA! HAAAAALLLL!
- David Bowie's first single to chart, "Space Oddity" in 1969, was inspired by the film.
- The music video of Lenny Kravitz song "Believe" is an homage to 2001 (old furniture in white rooms, space suits...).
- In the music video for "I Love It" by Kanye West and Lil Pump, the pair are seen walking down a hallway reminiscent of the one seen in the film.
- Hideo Kojima has also cited this as his favorite movie of all time and is frequently referenced in Metal Gear; Otacon is named after HAL and Solid Snake's real name is Dave.
- The villain of JumpStart Adventures 6th Grade: Mission Earthquest is a mad computer who takes over a space mission and talks in a soothing male voice. Sound familiar?
- JonTron chooses to go into the Star Gate rather than continue playing Cho Aniki in his Japanese Shoot-em Up episode.
- The ending to The Nostalgia Critic's review of The Garbage Pail Kids Movie is a straight up parody of the film's ending, only instead of becoming a starchild, he becomes a turd.My god. It's all full of shit.
- Animaniacs: Episode 81 features two bumpers based on the film, followed by the short "Our Final Space Cartoon, We Promise", in which the Warners disable the AL-5000 computer (who turns out to be Al Gore).
- Dexter's Laboratory: In "Dexter's Rival", Dexter's Computer asks "What are you doing, Dexter?" as he prepares to shut down his lab so he wouldn't compete with Mandark.
- Eek! The Cat: The episode "Eek Space 9" features several references to the film, including Sharky appearing as a Star-Child and a spoof of the "Open the pod bay doors" scene.
- In "Put Your Head on My Shoulder", a Monolith is seen in orbit around Jupiter with an "OUT OF ORDER" sign on it.
- In "A Bicyclops Built for Two", "Also sprach Zarathustra" plays when Fry signs onto the Internet, while he exclaims "My God, it's full of ads!"
- In "Insane in the Mainframe", the insane asylum that Fry and Bender are sent to is called the HAL Institute for Criminally Insane Robots. Bender gets sent there again in "Bender's Game".
- In "The Sting", Leela goes into space to find Fry's coffin and experiences the Stargate when she opens it.
- In "Near-Death Wish", the crew goes to the Near-Death star to visit the Professor's parents, and "Also sprach Zarathustra" plays when Fry presses the doorbell (a "ding-dong" replaces the last two notes). When they enter, Bender says "My God, it's full of geezers!".
- The Grim Adventures of Billy & Mandy: Near the end of "My Fair Mandy", the Stargate scene is parodied when reality falls apart due to Mandy smiling.
- In Milo Murphy's Law: The iconic musical cue plays when Lardee Boy's head floats in space.
- Phineas and Ferb:
- Phineas' verbal fanfare when showing off his highly unconventional vehicle: "Also sprach Zarathustra!" It's also a fairly popular piece of stock music for the show.
- In "Moon Farm", Isabella watches the moon cow ice cream race by in a colorful display evoking the astronaut's psychedelic descent.
- The film's Mind Screw closing moments are parodied in The Tag for "Mommy Can You Hear Me?", with Ferb as the star-child.
- Doofenshmirtz notices a group of crabs apparently worshipping his "De-Evolution-Inator". He even lampshades that there's something "Kubrick-y" about this.
- The Simpsons:
- "Lisa's Pony" opens with a parody of the "Dawn of Man" sequence in which, while the other man-apes gain ingenuity from the Monolith, a Homer-like ape just rests against it.
- "Brother, Can You Spare Two Dimes?", Homer experiences the Stargate while sitting on a vibrating recliner set to full power.
- "Deep Space Homer" features several references to the film, including a scene of Homer eating potato chips to the "Blue Danube Waltz", and the final scene of Bart tossing a marker into the air that becomes a scene of the FOX satellite floating through space (and hitting a Homer-like Star-Child in the head).
- In "Treehouse of Horror XII", the Ultrahouse 3000 computer from House of Whacks is based on HAL.
- South Park:
- In "The Tooth Fairy's Tats 2000", Kyle briefly appears as a Star-Child during the scene where he becomes an omnipotent entity.
- In "Trapper Keeper", the scene inside the giant Trapper Keeper is based on HAL.
- In "Bebe's Boobs Destroy Society", the boys regress into primitive mindsets thanks to Bebe's breasts, and Stan discovers a bone to beat the others with and become the alpha-male.
- In "You Have 0 Friends", Stan tries to get off of Facebook, but his computer says "I'm afraid I can't let you do that Stan Marsh."
- Tiny Toon Adventures:
- In "Animaniacs!", Buster and Plucky flash back to the dawn of man and see a bunch of apes beating bones around the Monolith.
- The short "C.L.I.D.E. and Prejudice" (from the episode "Elephant Issues") features the robot C.L.I.D.E., who talks like a mix between HAL and a game show host.