- A 2011 Payless Shoes commercial featured "I Am a Paleontologist" with a group of schoolchildren on a field trip to the museum and in particular them focusing on the dinosaur exhibit.
- In Experimental Film, Clark's favorite album is No!
- An episode of Pushing Daisies has Olive and Vivian sing "Birdhouse in Your Soul".
- In Friends Til The End, when Heather tells Nick that the idea of a two-person band will not be successful, he then says to tell that to Front Line Assembly, Nine Inch Nails and TMBG.
- As part of its Author Appeal, the series But Really Really Fast by Viva Reverie frequently uses lyrics from They Might Be Giants songs:
- The Stand description for Cream from JoJo's Bizarre Adventure: Stardust Crusaders But Really Really Fast is simply "A SNAKE HEAD EATING THE HEAD ON THE OPPOSITE SIIIIIIIIIIIIII-", quoting "I Palindrome I".
- The song "ECNALUBMA" is frequently given the Waxing Lyrical treatment in JoJo's Bizarre Adventure: Diamond is Unbreakable But Really Really Fast, particularly by the source material's main villain Yoshikage Kira. Also in the same episode, the hands in the ghostly alley tempt the heroes to turn around by quoting, well, "Turn Around".
- JoJo's Bizarre Adventure: Golden Wind But Really Really Fast references "Spiraling Shape" for a few dialogues and scenes, including the very end where Giorno defeats the boss.
- Tiny Toon Adventures made unofficial music videos for "Particle Man" and "Istanbul (Not Constaninpole)".Buster: Who are these guys?!