- Everyday Craziness in Pontypandy: In "Potato Queen Bronwyn", Bronwyn mentions that she and Gabby can watch a show while working, and puts on a show called Hallie, pastiching Oprah.
- In Ghostbusters (2016), Patty references Oprah Winfrey when she brings the hearse to their headquarters.Patty: You get a car! And you get a car! And you get a car!!
- In Nope, the protagonists refer to their hypothetical perfect photo of an alien that would bring them fame and fortune as “the Oprah shot”.
- In Harmony (2016), Alexandra sees Jenny McCarthy on Oprah, claiming that vaccines cause autism. Alexandra is annoyed with her for promoting such bad science, but she can understand the appeal.
- On All That, Kel Mitchell routinely played an obvious send-up named Okrah.
- A classic episode of The Fresh Prince of Bel-Air has the family going on the show where their dirty laundry ends up being aired. And at one point, Carlton dances to the show's past theme song.
- In Living Color!:
- One of the first skits (that Kim Wayans eventually came to regret) had her portraying the host on her show, consuming a lot of food and getting so angry that she explodes.
- Another skit had a public service announcement spoofing the popular "Brain on Drugs" ad that also shows Oprah using the egg as drugs, bacon as alcohol and ultimately putting the "drugs" on a hard roll and eating it.
- Another Oprah skit had her owning a restaurant, meddling in people's lives and revealing to the patrons that the food they've been eating has been fried in the fat she's lost over the years.
- Married... with Children: The show has taken several potshots at the show over the years, since Al hates it but Peg, of course, loves it.
- Margaret Cho's show All-American Girl had an episode with her and her family appearing in the studio audience of the show.
- On The Jerry Springer Show, whenever a guest or audience member says something that is too "wimpy" for the show, the rest of the audience will begin to chant "Go to Oprah!"
- In the Drake & Josh episode "Josh Runs Over Oprah", Drake gets Josh (an Oprah fan) tickets to the show for his birthday. As you would expect by the title, they end up accidentally hitting her with their car. (She survives, but gives Josh a restraining order.)
- A recurring segment on The Late Show with David Letterman was "Pat and Kenny Read Oprah Transcripts" where stagehands Pat Farmer and Kenny Sheehan read Oprah transcripts, with Pat as Oprah and Kenny as the (usually female) guest of the day, in deadpan voices. They even made a Shot-for-Shot Remake of Oprah's "Do It Yourself" Theme Tune.Pat as Oprah: Wooo hooo. Wooo hooo. You go girl.
- In the Gravity Falls episode "The Stanchurian Candidate", Bud's "You get fifty per cent off! You get fifty per cent off! You get fifty per cent off!" is done in a manner that's an obvious riff on the famous episode where Winfrey gave everyone in her studio audience a free car.
- The Simpsons: In "Husbands and Knives", a newly successful gym owner Marge goes on an Oprah Expy named Opal, where she then asks the host when her boyfriend Straightman was going to pop the question, which she [Opal] deflected by giving out expensive German cuckoo clocks to the audience.
- Sesame Street had an animated insert called "The O Show", whose host was a talking letter O. The insert featured an orangutan talking about his favorite O foods, an octopus that juggled, and a giveaway of oboes.
