In "The Springfield Files", Homer tells Lenny and Carl a trick he learned from watching the film.
"I saw this in a movie about a bus that had to speed around the city, keeping its speed over fifty, and if its speed dropped, the bus would explode! I think it was called..The Bus That Couldn't Slow Down.
In "Bye Bye Nerdie", as Otto's drag race with Marge is styled like a scene from the film; Milhouse exclaims "Wow! It's just like Speed 2, only with a bus instead of a boat!".
There was also an issue of the Simpsons Comics that directly parodies Speed, with Sideshow Bob rigging the Springfield Elementary bus with a bomb as it's main plot.
Actually, to be exact, he'd rigged Bart's usual seat on the bus with a massive spring that would launch the seat (and thus Bart) out of the bus once it went too fast; everyone on the bus just assumes it's a bomb because Bart (who was ironically kept back in detention for that field trip) overheard Bob leaving a message on Skinner's answerphone but the machine cut in before Bob could specify the nature of the threat.