On page 1,020 of Flare, the Steel Shrike overhears a TV set: "Alex, I'll try Superheroes for fifty!" On the next page, the Steel Shrike suspects that Harrigan, Teresa's butler, has set a trap by hooking something into the TV set, such as a blinding flash. Harrigan replies, "I would never so dishonor Alex Trebek!"
Agent K: I don't suppose you know what kind of alien life form leaves a green spectral trail and craves sugar water, do you? Agent J: Uh, wait, that was on "Final Jeopardy!" last night. Damn, Alex said...
White Men Can't Jump: Gloria spends every minute she can studying so she can become a contestant on the show. Eventually, thanks to Sidney's connections, and Billy making an impossible shot, she gets her shot as a contestant, and proceeds to win big.
One The Far Side strip had a man competing with Albert Einstein and Thomas Edison, with a score of 100; he claims that his buzzer was broken.
In a Sunday Strip of Gasoline Alley, Walt Wallet is a contestant on "Foolhardy!" hosted by Alex Trivial. In the Baseball category, Walt is stumped by the answer "The fans." The question: Who lost the 1994 World Series?
Charlie Brown: Someone told me that you like me only because I feed you. Is that true?
Snoopy: I think I'll choose another category I'll take Famous Characters in History for $400, please!
Pearls Before Swine: One of the crocs manages to get on Jeopardy! and amazingly does well due to subconsciously absorbing information from TV shows in his sleep. Unfortunately for him, they don't accept "Zeeba" as a final Jeopardy! response, which he put all his winnings on...
Stay Tooned!: One of the in-universe TV shows is Shlepardy!, hosted by Al Extra Bucks. It is also a mini-game you can play when you enter the Castle Room and click on the television set. You'll need to play this game and win at it in the path where the elevator button to Floor #5 is missing, since it is one of the prizes you can get if you win.
Rugrats: In "Game Show Didi", Didi appears on Super Stumpers, a game show akin to Jeopardy!, hosted by Alec Quebec (voiced by Alex Trebek himself). At one point, Quebec has to remind Didi that her answer doesn't have to be in the form of a question.
In the Scooby-Doo and Guess Who? episode "Total Jeopardy!", Velma and Shaggy compete on the game show against a robot named Max Kilobyte. Alex Trebek appears as an Ink-Suit Actor hosting the show.
The Simpsons: In "Miracle on Evergreen Terrace", Marge goes on Jeopardy! in the hope of winning $15,000 to repay the people of Springfield after she spends their money on a $12,000 car that sunk into icy water. Marge loses so badly that she ends up owing $5,200 to Alex Trebek. Trebek doesn't take kindly to Marge's loss, and joins the Springfieldians in repossessing the Simpsons' possessions at the end of the episode.
Tiny Toon Adventures: Gyp-Parody appears on "KACME TV", this time hosted by Buster, with Dizzy, Calamity and Elmyra as the contestants. No one gets any of the answers right, due to Dizzy eating his podium, Calamity's buzzer not working, and Elmyra answering "What is a bunny?" to every question (except the one where it would be the correct answer).