After Homer finds a letter and a video revealing that Marge only married Homer because he got her pregnant, Homer moves out (again) and finds himself in Springfield's gayborhood, living with two homosexual roommates.
- As Himself: "Weird Al" Yankovic.
- Big Beautiful Man: One of the residents of the gay neighborhood refers to Homer as a bearnote and growls flirtatiously at him.
- Blatant Lies:
- Homer runs into Smithers in the gay neighborhood while walking through the streets. Smithers immediately tries to deny his presence, saying he got lost on his way to the "big monster truck show". His claim isn't helped when a trolley of Smithers' gay associates passes by, prompting them to ask if Homer is the "Mr. Burns he's always talking about".
- When Chief Wiggum catches Moe dumping Homer at the hospital with alcohol poisoning and demands an explanation, Moe claims Homer was drinking "at Harrigan's Pub down the street".
- Both Sides Have a Point: The fight between Homer and Marge has valid points on both sides. Homer's understandably upset when he finds Marge's angry letter after their night out and that she had a doctor's appointment because she was pregnant and believed she only married him because of that and secretly hates him. Marge doesn't do much do dissuade this perspective. Although she is right that Homer has more than a few flaws that annoy her, she refuses to apologise for upsetting Homer and hurting his feelings out of trying to hold the moral high ground.
- Brain Bleach: A lesbian patron is grossed out by Homer's dancing and remarks it "makes her even more lesbian".
- Cameo: "Weird Al" Yankovic, which he lampshades during the credits.
- Camp Gay: Julio and a few one-scene residents.
- Comically Missing the Point: Hans Moleman apparently attended a gay club while under the impression that it was his army reunion. A burly man in revealing military garb picks him up, but Moleman assumes he's an actual Colonel.
- Continuity Nod:
- When Lenny and Carl are looking for Homer and find him busy at home, they ask, "Is he Poochie again?"
- Homer's Pin Pals and Mr. Plow outfits are seen in his closet.
- Fully Automatic Clip Show: The credits, set to Weird Al's parody of "Jack and Diane", shows clips from the episode. However, they also include a deleted scene of Marge managing to lift the fridge and cleaning underneath it.
- Granola Girl: Mentioned as Julio and Grady prefer Homer over "that girl who wrote "Mother Earth" as a reference".
- Halfway Plot Switch: The family works on a jigsaw piece, but they can't find the last piece. While Homer is searching, he comes across Marge's memory chest, and finds a note from the opening night of Moe's Tavern — Marge was very unhappy and nearly left Homer, causing him to wonder if she still loves him. He leaves the house and winds up in a gay neighborhood, starting the main plot.
- Hypocritical Humor: At lunchtime, Nelson sees Bart sorting puzzle pieces, assumes that he's so poor he has to eat cardboard, and laughs at him. Then he proceeds to eat a drywall sandwich.
Homer: Marge, did I ruin your life?
- Moe forcefeeds Homer so much booze until he gets alcohol poisoning to stop him from realizing he has alcohol problems.
- Patty and Selma are on fine form; Marge mentions they're trying to get a legal bill passed to have Homer kicked out of Springfield.
Marge: Oh, is this about that billboard my sisters put up? (opens the bedroom curtains to reveal an animated billboard outside, alternating between the words "Homer out of Springfield — Vote Yes on 104", and Patty and Selma kicking Homer in the backside by a "Leaving Springfield" sign)
Homer: No. The voters will decide that in November.
- Song Parody: "Weird Al" Yankovic, the king of this trope, performs one of John Mellencamp's "Jack and Dianne" called "Homer and Marge."
- Sudden Name Change: Casa Nova from "A Milhouse Divided" makes a reappearance, except it's now called Bachelor Arms.
- Take That!: An in-universe example:Homer: You guys don't have a gay time machine, do you?
Julio: Yeah, it's called Grady's shoe closet.
Grady: Hey, Julio... ouch.
- Time Skip: The ends with a skip to a future when Dr. Hibbert is an elderly man watching tape recordings from cameras he used to set at his workplace to figure out if the nurse was stealing sponges. Upon watching the one where Homer and Marge reconcile, he finally learns that she was indeed stealing sponges.
- Wide Eyes and Shrunken Irises: Homer gets these when he hallucinates Lenny as a giant jigsaw piece.