Gaslighting: Covington chooses people with the MAO-A2R gene, which predispositions them to anti-social behaviour. He puts these people under enormous stress taking their relationships, work, and reputations away causing them to snap.
Psycho Psychologist: Creel is a hospital therapist who was formerly part of a black-ops government mind control programme, and now uses his skills to actually turn people into killers.
Shown Their Work: Cooper correctly mentions the existence of Mkultra, which was a CIA-backed program to conduct research on mind control.
Well-Intentioned Extremist: Creel is sincerely believes that perpetrators of random killing sprees should not be held responsible for their actions because they are a victim of circumstances and genetics beyond their own control...and he tries to prove his theory by manipulating people into doing just that, believing that if he can show the world he was right, people with the faulty genes can be identified and cared for to ensure such crimes never happen again.