With Amy away, Sheldon's old admirer Dr. Ramona Nowitzki begins to hang around him at Caltech and later his home. The rest of the gang become convinced she is pursuing Sheldon, alarming Amy. They do their best to keep her away from him, even following her to her car after dinner as a group. Sheldon doesn't believe Ramona is romantically interested in him, but when he asks her about it, she kisses him. Sheldon immediately departs and flies to New Jersey, proposing to Amy the second she answers the door.
- The Bus Came Back: Dr. Ramona Nowitzki from the second season returns
- Cliffhanger: After Dr. Nowinski kisses Sheldon, he goes all the way to New Jersey. He knocks on Amy's door, she opens the door to meet Sheldon on one knee proposing to her, and that's where Season 10 ends.
- Green-Eyed Monster: Amy is furious that Ramona is flirting with Sheldon.
- Mood Whiplash: After Ramona kisses Sheldon, he runs away. We then see him boarding a taxi, getting on a flight, and watching SpongeBob SquarePants. Then he arrives at Amy's apartment and knocks on the door...and when she answers, he gets down on one knee and pulls out a ring.