An unsuspecting traveler brings a blood-sucking legend with him to Portland, and Nick and Hank find themselves investigating the gruesome trail of "El Chupacabra." Meanwhile, Monroe and Rosalee prepare to leave for their long-overdue honeymoon as they are met with more threats regarding their marriage. Elsewhere, Viktor and Adalind decide to take a trip of their own, while Wu decides to confront Nick about what he has been seeing.
This episode provides examples of:
- Heroic Sacrifice: When he sees that his wife is infected and Rosalee only has one dose of the antidote, Diego grabs the syringe and plunges it into her back, ensuring that she is the one who is saved.