After the family attends a streaming convention, Meg decides to start her own online show in which she would eat anything she could find. However, this takes its toll on her during a live appearance in which she collapses in a diabetic coma.
Meanwhile, after Stewie and Brian get kicked out of the convention, they are in involved in an accident. After being insulted for driving a 'girly' car, Brian insists on their most macho loaner car available and is given a Hummer. Luckily, he is available to help rush Meg to the hospital when she collapses.
At the hospital, Meg and the family learns that she has become diabetic, but her taste for fame drives her to continue her eating, and it soon costs her her feet. When she is honored at school, she realizes that all of her friends have become fat because of her. as she pledges to eat healthy and try to save what's left of her health, the bleachers the students are on collapses, resulting in the death of a janitor. Dr. Hartman is able to give Meg a foot transplant from the body.
When the time comes for Brian to give back the Hummer after his car is repaired, he is heartbroken but Stewie manages to wreck the rear then it went up in smoke, the car exploded putting Brian and Stewie in coma for weeks.
Back at home Fat Meg and ask Lois to be her trainer she was delight. Lois yells at Peter for the events that happened, Meg, Patty, Ruth and Esther now has the shinning.
This episode contains examples of:
- Actor Allusion: For the Road House (1989) bit at the end, Sam Elliott joins in and reminds viewers he was in that movie.
- Balloon Belly: In a brief Twitter photo of Meg advertising a painful brand of toilet paper, she has a swollen gut from all her binging. She later gets even fatter from all her binging to where she loses her feet due to type-2 diabetes.
- Big Eater: Meg uses her talent for eating to get famous, which gets her morbidly obese later on.
- Body Horror: Meg's feet rotting end up turning black due to her type-2 diabetes.
- Call-Back: Stewie makes a reference to not being allowed to use Beatles songs, which was brought up in the previous episode "Throw it Away".
- Cluster Bleep-Bomb: When Meg tells Peter obscene things she can do, they're covered with long bleeps, even on the DVD release.
- Growling Gut: After stuffing herself full of food (coffee creamer, strawberry yogurt, whipping cream), it seems that the raw bacon in particular aggravates Meg's stomach to the point that it starts gurgling and rumbling nonstop until she goes to the bathroom and relieves herself.
- Heel Realization: When Meg is honored at school, she realizes that all of her friends have become fat because of her.
- Lampshade Hanging: Patty, Ruth, and Ester point out their massive weight gain would be shocking if anyone remembered what they looked like.
- Laser-Guided Karma: Brian and Stewie get this when the do donuts in Mark Ruffalo's lawn. With him turn Hulk and throwing them and the Hummer into New Hampshire
- Not So Above It All: Seamus, Rupert, and Consuela all follow Meg's show.
- Plotline Crossover: Sam Elliot occasionally does narration for Brian and Stewie's plot. After that plot ends, Meg makes a comment about not wanting anyone to lose their feet.
- Shout-Out:
- The title is a reference to the film Girl, Interrupted.
- KISS' "Lick It Up" plays on every channel in Brian's Hummer.
- Peter, or rather, an ice cream replica of Peter, recreates Han Solo frozen in carbonite by using Smucker's Magic Shell.
- The sound effect played whenever Meg's followers are shown to increase is the startup sound from the original Game Boy.
- Refrigerator Meg wears what appears to be a Chicago Bears football jersey. William "The Refrigerator" Perry wore the number 72 with the Bears from 1985 to 1993.
- Skewed Priorities: At the hospital, Meg and the Griffin family learn that she has become diabetic, but her taste for fame drives her to continue her eating while becoming a spokesperson for Pancresta, and it soon costs her her feet.Sam Elliot: Feet, those little weirdos on the end of your legs. I used mine to mosey on over to the A story.
- Spot the Imposter: Between a Peter dressed as a chef and a Peter that's been encased in vanilla ice cream covered in chocolate à la Han Solo. Lois doesn't know who the imposter is, so the chef Peter points out he's clearly a guy and that the other is clearly ice cream. Lois immediately stabs the Peter encased in ice cream, but then the chef Peter starts melting and suggests lowering the temperature to 32 degrees.
- Take That!:
- Corey claims that "all the Jewish kids stayed home from school that day." This is a reference to the many YouTubers such as PewDiePie who have been criticized for alleged antisemitic statements, and the persistent conspiracy theory that claims that Jews/Israelis were warned not to go to work at the World Trade Center on 9/11.[1] In reality, over 270 Jews and 5 Israelis died in the WTC.
- The episode features a sarcastic pitch for Triscuit.
