The classic "I don't have your stone! And fuck you anyway!"
And of course, one of the endings:
Lucifer: I'm the light bringer! I'M THE FUCKING UNIVERSE!
The first and heretofore only F-bomb in ARK: Survival Evolved comes in the post-finale cutscene of the Genesis: Part One expansion, when the player completes the simulation and awakens in the real world, only to be attacked by a tentacle that looks suspiciously like Rockwell's. Although HLN-A censors herself with a Sound-Effect Bleep, the severity of the situation is still evident.
Example A: What the eff, guys? Just because Mommy can be a psycho-bitch on occasion doesn't mean you have to cast a sociopath! Example B:Shut the hell up! We were never tools, you stupid asshole! Example C: If Tsubaki were here, she'd give me such shit for sleeping in the middle of an important mission... never mind that I'm on an aircraft and can't do crap, anyway...
Likewise, you know Valkenhayn is angry when his language goes bad (anything regarding Terumi fouls his mood real quick).
Valkenhayn: Imbeciles! Don't they realize what that shitty little cur is capable of...?
Moxxi generally isn't much for swearing - she'll do it, but only rarely. Then she finds herself in Mr. Torgue's Campaign of Carnage, with Tiny Tina hijacking an interview she was doing with Torgue to work on her sponsored Vault Hunter's PR.
From Braid: "Now we are all sons of bitches." This is a reference to a quote by Kenneth Bainbridge just after the testing of the first atomic bomb, one of the many layers of allegory that the game has.
Eddie: I told you not to climb on that, you stupid mother—[a notification appears on-screen asking if the player would like to hear the swears, or bleep them]...FUCKING PIECE OF SHIT! Lars: The time has come for you to SHUT THE HELL UP, Lionwhyte! Eddie: Dude, how 'bout this? How about you pick up your little baby foo-foo, lay down your diaper, and GO DO YOUR FUCKING JOB RIGHT NOW?!
In Castlevania: Order of Ecclesia, the third boss in the game consists of a gigantic crab that the heroine Shanoa must fight all the way up a lighthouse. At the top, Shanoa gets into an elevator, tells the crab to "go to Hell", and rides the elevator all the way down, crushing the crab. This is made all the more awesome by the line appearing as a sound bite rather than as a text box. It bears mention that the original Japanese phrase ("Jigoku ni ochiro.") translates to "Fall into Hell." and, when used in its entirety, is at least somewhat less offensive than its English equivalent.
Castlevania: Judgment has one of Grant's "damn"age grunts be a certain four-letter word. Can you guess what it is?
And the living/warm their bones/won't retaliate/fuckin' drones!
In Neo Contra, Bill Rizer does this by using "Hell" while against Pheromone Contra (Lucia) and Master Contra.
Dead Island: Riptide does not shy away from the F word at all, for the most part. The exception is Xian, whose reaction to smashing a bulldozer loaded with fuel into the quarantine zone is a small "Oh my god." It takes something more than that to set her off, once after the virus causes a massive Berserker Rage, and again at the end when after learning the virus outbreak was deliberate and the victims experimented on and having to stop a crazed, purposely infected Harlow, she confronts Serpo, who openly admits to causing the disaster to test and later sell the virus.
When fighting Sanctus, one of the things Nero will say when using the Devil Bringer is "I'm not interested in your bullshit!", with a punch to the face for effect.
One of the things Nero says when doing a DTd Buster on an Alto Angelo sounds a lot like "fuck you!", but this is somewhat debatable since it's not as easy to make out as the above one.
In Devil May Cry 5, during the final battle with his father Vergil, Nero's first unleashing of his true Devil Trigger is punctuated by a furious "FUCK YOU!"
Donkey Kong 64 has this line during the DK Rap (to put it in perspective, this occurs in an E-rated game): "He may move slow, he can't jump high, / But this Kong's one hell of a guy!" This gathered huge amounts of complaints from parents, so in the remix in Super Smash Bros. Melee, they changed it to "heck" (despite the fact that Melee is a T-rated game).
Halward: I only wanted what was best for you. Dorian: You wanted the best for you! For your fucking legacy! Anything for that.
A possible piece of Party Banter between Cassandra and Cole has the former asking the latter if his powers as The Empath enable him to pick up on any secret pain afflicting Evil Sorcerer Erimond, a quest arc villain. The usually airy and cryptic Cole readily responds "No. Erimond is an asshole."
The Trespasser DLC has one, should you choose the angry response to your mark flaring up in the middle of a heated argument between your advisors. It's probably the first time a BioWare protagonist uses the word:
Inquisitor: Shit! Damn it! We saved Ferelden, and they're angry! We saved Orlais, and they're angry! We closed the breach twice and my own hand wants to kill me! COULD ONE THING IN THIS FUCKING WORLD JUST STAY FIXED?
In Dust: An Elysian Tail, when Dust, Fidget, and Ahrah return to the Mudpot Village after liberating the water supply for the village, they find out that BoPo's father and MaBop's husband passed away while they were gone. Dust takes it very hard.
The language in The Elder Scrolls V: Skyrim is usually pretty mild (to us, anyway: characters tend to swear using the names of their gods and it's never stated how profane it's considered to be), which makes it all the more satisfying when Ulfric Stormcloak calls it like it is in regards to Elenwen - at a peace conference, no less:
Ulfric: To think that we would sit down with that... Thalmor bitch!
In Evolve, Bucket has precisely one line of dialogue where he curses. Said line is delivered in the same deadpan tone as all his other lines and comes only if everyone else on the team is killed.
Bucket: Well fuck.
In Fabulous: Angela's High School Reunion, Level 49 shows a cutscene where Janet calls Angela a bitch. What's interesting about this is that while it was censored in English, it wasn't censored in other languages, making this game the first Gamehouse Original Story to include an uncensored swear word.
Janet: ANGELA knows? That BITCH!
One of the routes you can take in Façade has one when Grace admits that she's been secretly painting to Trip:
Towards the end of the game you get the opportunity to pull one off when you're being captured and interrogated by Col. Autumn, who wants the activation code for the purification device. It's especially impactful if you've been playing through the game with good karma.
Autumn: You tell me that code, and maybe we can work out a deal for you. The Lone Wanderer: Fuck you. I'm not telling you anything. Autumn: I'll be honest. I'm running out of patience here, and I'm not looking to play games with you. You tell me that code, or it's going to cost you. The Lone Wanderer: No, seriously. Fuck you.
Burnt Skeleton's placard: We're dying out here, assholes!
Talon Company Merc: "I want this one's head on a fucking plate!"
The biggest one is probably from Madison Li at the end of "The Waters of Life". Normally a cold but certainly clear-headed woman, she ends up watching the man she harbors unrequited feelings for sacrifice himself, and then has the dream of Project Purity crushed for a second time. After that, her life, and the lives of all her companions are put into the hands of the kid who's a constant reminder to Li of James. Then, finally after narrowly escaping death, she's denied sanctuary at the one place where the group would be guaranteed safety. She sounds like she's on the verge of tears.
Madison: Lyons! I know you're in there, I know you can hear me, you open this goddamn door right now!
A memorable one occurs when after tracking Benny down to the penthouse he's staying in, if allowed to leave he quickly double-crosses the Courier and attempts to murder them (again) by sending up a squad of goons. He then calls over the intercom.
Benny: The cleaners will knock twice. Tell them to be thorough. Courier: It's a real mess in here - four bodies. Benny: ...What the fuck?!
Another one from Benny: if you choose to have him crucified by Caesar's Legion, he does not take this well:
Benny: You sick, vindictive fuck!
Since being a package courier involves trekking across post-apocalyptic wastelands, often by oneself, it seems no wonder that Cass claims that one of the rules of the Caravan Wastes is "Don't fuck with the guy who delivers your mail".
Though it's not as vulgar as the other examples on this page, the normally G-rated language Final Fantasy VIII has three notable instances.
When one minor character very nearly kills another by accident (by hanging him with a fishing line, no less), the almost-victim understandably berates his idiotic pal, finishing up by calling him "DUMBASS!" Complete with red text and a slashing sound as the word is said, to drive home the point that yes, this is as foul as the language is going to get. Maybe they were trying to avoid what happened with Final Fantasy VII.
When Zone, one of Those Two Guys, lays into Squall for letting Rinoa get hurt: "YOU SON OF A BITCH!"
When Squall and party overhear fatherly and normally ineffectual Headmaster Cid arguing with Garden Master NORG:
Headmaster Cid: Greedy son-of-a-bitch! [...] Dammit! I should've never trusted you! I wish I could go back ten or so years. To tell myself that you're nothing but a money grubbing son-of-a-bitch!
Dr. Wallace Breen, ever the the classy and intelligent villain, never stating so much as a "darn", lets out a loud and clear "Oh, shit!" when he sees that Gordon and Alyx are close behind him during his conversation with an Advisor.
Whenever Cyborg in Injustice: Gods Among Us swears, it arguably feels like this trope since he is heavily patterned after the cartoon version of the character, including having the same voice actor. So when he says "You're lookin' for an ass-whoopin!", it sounds like Cyborg from the cartoon is swearing.
There's a fair amount of cursing in Injustice 2, but Captain Cold gets the only one to actually require a Sound-Effect Bleep in the entire game... when he calls out Gorilla Grodd at the end of his arcade mode while putting him on ice.
Captain Cold: You really thought I'd go through with it, Grodd? Really?! F[beep] YOU!
"Just how much more hell do they intend to raise?"
Some of the characters in killer7 let these out after hitting a Heaven Smile's weak spot - young punk Con Smith jubilantly shouts "FUCK you!" and shady thief Coyote Smith snarls, "You're fucked." Depending on how good the player is at hitting the Smiles' weak points, this can quickly turn into a Cluster F-Bomb.
In Klonoa 2: Lunatea's Veil, after defeating Cursed Leorina, she falls to her knees, crying "Damn it! Damn it all!" In an E-rated game.
In the GBA game, Empire of Dreams (also rated E), Klonoa says: "Damn it! Not again!" when Jillius's troops spot him in World 5.
Cole Phelps in L.A. Noire loses it when his crooked ex-partner Roy Earle snidely insults the dead Courtney Sheldon.
Cole: He was a better man than you'll ever know. You say one more word about him and I will blow your fucking head off!
Lost Planet 2 doesn't have any qualms with using foul language when appropriate, but this line from the lead Rounder at the end of Episode 3 takes the cake: As he mans the controls of a railway gun to fight a massive Akrid:
Subverted in Madagascar, where after Wilbur the Warthog attempts to help Marty in his quest to find Alex by pushing a rock out of a passageway, an incredulous Marty says he's "about to lay a can of whoopa-butt on you, Warthog!" It is however played straight in the New York City Street Chase level, where an NPC says that Manhattan's "full of freakin' animals" upon seeing Alex, Gloria, or Melman.
Jack:[to Joker] Screw you, F...light Lieutenant. Joker: ... Eheh, what was that? Shepard: Jack's been watching her language for the kids. Joker: What, does she have a swear jar or something? Because if we emptied that out we could afford a new cruiser. Jack: Cover your ears, kids. Hey Joker, f[Loading Screen]
Most of the profanity in the game comes from the Player Character, Ryder. They swear much more often than Shepard, but don't use obscenities as punctuation like Jack did.
Suvi Anwar is normally the most soft-spoken and proper member of the crew, only letting out a single "hell" during a tense moment in the beginning of the game. Which makes it all the more jarring when she drops this gem near the end.
Suvi: Pardon my Martian, but it's all weird as shite.
Later on, when things get worse, an aggravated Suvi drops a double-shite bomb.
Jaal, not normally one for swearing, drops the occasional cuss.
Mega Man X has a couple "damn"s in the early games, which were kept in the X Collection. In fact, one "damn" (from X no less) was actually added to the first game for some reason. Although the fourth game missed its chance by having a late boss character shout, "See you in the underworld!" rather than the less unwieldy "See You in Hell!"
In Mega Man 7, Bass throws in a rather unexpected "damn" in a dialogue toward the end of Shade Man's stage. Mild by the standards of a T-rated game, but it's quite surprising in a KA-rated SNES game. Too bad it was taken out in the Anniversary Collection.
Mega Man Battle Network 2 has several instances, such as when, after you defeat MagnetMan and expose Gauss as trying to crash a plane, he lets out a rather unexpected "Damn it to hell!"
In the Japanese release of Metal Gear Solid 3, EVA, when cornered by Colonel Volgin, snarls "fuck you" before trying to shoot at him with a concealed gun. In the English version, the line was changed to the more mild "go to hell" - although it was saved by the voice actress's delivery.
The series is very low on swearing, so the one F-bomb in Metal Gear Solid 4 is a laser-guided Precision F Strike indeed. Delivered by what turns out to be a mind raped psychopathic teenage girl who never stopped her deranged laughing for years, "It's all so FUCKING HYSTERICAL!" manages to creep you like you wouldn't believe. Especially considering the creepy nature of the boss fight, against an enemy who uses stealth against you. Cue the nightmares.
In the final moments of the game, you, as Soap, get stabbed in the chest by General Shepherd, whom you've been chasing for the majority of the last mission. As you stir, he gives you his Motive Rant, starting:
Shepherd: Five years ago, I lost 30,000 men in the blink of an eye. And the world just fuckin' watched.
In "Wolverines", when an enemy drone targets the restaurant you're on top of: "Ramirez, get the fuck off the roof!"
In Mortal Kombat: Shaolin Monks, Scorpion has a small chance of punching up his iconic catchphrase when using his spear, either as "GET THE FUCK OVER HERE!" or "GET OVER HERE, BITCH!"
Resident Evil 2 (Remake) have both Leon and Claire swear to varying to degrees when aiming their weapon at a zombie, ranging from "WHAT THE FUCK!?" to "You bastard!" Leon's encounter with the mutant alligator has him screaming "HOLY SHIT!!!" as he tries to run from it. Leon also gives an exasperated "Is this a fucking joke!?" when Mr. X ambushes him while he's trying to escape from the lab. If Leon is the one to finish off the G monster at the end of a 2nd Run game, he'll shout "Fuck you!" as he jams a pipe into its eye. Claire is no slouch in the swears either, where her most notable one is her screaming "I'LL GET YOU, YOU FUCKER!" when Chief Irons kidnaps Sherry.
In Resident Evil 5, Chris Redfield has a pretty good one towards the end, when forcing an overdose of serum onto Wesker: "I've had enough... of yourBULLSHIT!!"
Leon Kennedy has an even better one in Resident Evil 6 while fighting the man who murdered his partner's sister (and then forced them to kill her again) and forced him to kill an old friend. "Kill this fucking bastard!" Double the impact because Leon is usually a deadpan snarker who rarely swears.
While The Boss has no qualms about swearing, one instance stands out in particular in how appropriate for the moment it feels. After falling out of a plane, hijacking a battle tank mid-air, and fending off an entire wing of jet fighters with it, the Boss finally lands in Steelport—only to discover that the whole neighborhood was turned into a localized Zombie Apocalypse the Saints now have to deal with, too.
Boss:[exasperated groan] Oh, fuck my life. [hops back into the tank]
If you go for the "Save Shaundi" ending and stop Kia from blowing up Magarac Island, Monica Hughes will call out Cyrus Temple for still trying to go after the Saints.
Monica Hughes: You declared martial law and destroyed half of the city; the Saints just saved a treasured monument. Who the fuck do you think the public will side with?!
In Saints Row IV, when the Vice Kings go after the Saints in Ben King's simulation, King releases this combined with a Badass Boast.
The game gives the main character a chance to say "Calm the hell down!" during a particularly... tense... moment after his cousin/surrogate little sister seemingly dies and the main characters contemplate killing the man they think is responsible. The above line is used in order to calm down the protagonist's understandably furious friends and get them to think more rationally. The protagonist can curse several times throughout the game, but the delivery of this is what makes it especially poignant; he yells and gets visibly angry for the first, and only, time in the entire game. The opposite decision's line is just as unexpected, but more chilling: "Throw the bastard in."
Due to being the game's Yamato Nadeshiko, Yukiko usually reigns in her curses as much as possible. So during Rank 8 of her Social Link, when hounded by a particularly misogynistic "reporter", she barely maintains her composure until said "reporter" suggests that the Amagi Inn would be better as a whorehouse than an actual inn... which really sets her off, and she mutters to him to "...[shut] the hell up." This is the only time she consciously curses in the entire game (her Shadow Archetype, who is a Lady Swears-a-Lot, is Yukiko's hidden fears going haywire, and the other time she curses is when she's Drunk on Milk and it's Played for Laughs), and it's particularly chilling for how furious she sounds.
Persona 5 has some of this as well. It's nothing unusual if Ryuji cusses, but if Ann or Makoto break out the profanity, you might want to reconsider your life.
Shadow Kamoshida has Ann captive and decides, at the behest of Princess Ann, to have her chopped up, starting with her clothes. With some prodding from the protagonist, Ann decides to tell him off in a way that makes Carmen take notice.
Ann: You're right. Letting this piece of shit toy with me... what was I thinking? Kamoshida: It's like I always say. Slaves should just behave and- Ann:Shut up. I've had enough of this... You've pissed me off, you son of a bitch!! Carmen: My, it's taken far too long.
Shadow Kamoshida fires one back after Ann awakens Carmen.
Ann: You know what? I'm not some cheap girl you can toy with...you scumbag. Kamoshida:Bitch!
Shadow Kaneshiro starts negotiating with Makoto in regards to dealing with her new friends, bringing her down as he talks. Then he decides to mock her desire to prove herself and her relationship with her older sister. Needless to say, he stares an atom bomb in the face the next moment.
Kaneshiro: You'll earn three million yen in no time. Although, your life and everything along with it will be a complete wreck by then! [laughs] Makoto: I've been listening to you go on and on... Shut your damn mouth, you money-grubbing asshole! Kaneshiro: Huh? Johanna: Have you decided to tread the path of strife...? Makoto:Yeah. Come to me!
In the Japanese audio for Sonic Adventure, Sonic says "shit" once. Translated to something along the lines of "darn" in the American version.
A mild example: In Sonic Heroes, Vector calls Rouge a "broad" in the cutscene preceding the Team Dark/Team Chaotix boss battle.
Shadow the Hedgehog has the infamous "Where's that damn fourth Chaos Emerald?" line. (Interestingly enough, the subtitles put the emphasis on "fourth", but the voice actor puts the emphasis on "damn"). Also, when Shadow dies in that game, he'll exclaim "Damn! Not here!"
Another milder example comes from Sonic and the Secret Rings: When wondering what possessing all seven World Rings could do, Sonic ponders, "It might even open the gates of hell..."
Sam Fisher of Splinter Cell hardly ever curses, which is particularly noticeable in Conviction, where he's pitted against Mooks who prefer Cluster F Bombs. So, throughout the game he has a few that really stand out, particularly when he tells people to go fuck themselves.
In Malta, having no family left, his agency wanting to kill him, trying to find a reason to go on, Sam is pursued by thugs hired by a drug and arms dealer to kill him. After easily (and brutally) taking care of the Mooks, he finds the leader who tried to run away, but ran into a dead end in a bathroom.
Sam: Looking for me, asshole?
In a Flash Back mission during the Gulf War, Sam is captured by (presumably) Ba'athist soldiers and is interrogated by two men, and apparently of the English those two men have learned, half are vulgar terms. When they threaten Sam with Electric Torture, his only response is a quiet, gruff "Go fuck yourselves. I'll be here when you're done." For maximum effect, barge in and rescue Sam right after this point, but right before they start torturing him.
Sam still drops one even after he's been shot in the shoulder and had his hands bound by Grim, who for all Sam knows at this point may still be suffering from Chronic Backstabbing Disorder due to what has been going on throughout the game, and is at the moment in front of a similarly captive President, Smug Snake Tom Reed, and about five actual highly trained splinter cells, when Reed asks how it feels knowing he's about to go down in history as the man who assassinated President Caldwell.
The game plays both sides of this trope. Units will frequently refer to "chicken-[beep] outfits" and not having time to "f[beep]k around", but in cutscenes "shit" and the like are thrown uncensored whenever it's deemed dramatic enough.
Remember Kerrigan calling herself the queen bitch of the galaxy? The (unofficial) Hungarian version made her the "Fuckin' Queen of the Galaxy".
Pam swears at Penny when she finds the two of you cleaning her trailer during Penny's 4-star heart event. This incident heavily implies that Pam is an abusive drunk, and is one of two curses in the game...
... the other being a complete subversion: one of Alex's casual chatter lines in summer is "Do you smell barbecue? Damn, I could go for a burger."
There isn't a whole lot of cursing in Strife: Quest for the Sigil at all, but when you witness the leader of the resistance, Macil, descend into Sigil-induced madness and self-perceived godhood first-hand, your Mission Control/Voice with an Internet Connection, Blackbird, lets loose one well-timed curse in response:
Blackbird: Sick fuck... Waste him!
Super Tennis has the losing player say "Shit!" in the original Japanese version. It was censored to "Rats!" in international releases.
In Syndicate (2012), Jack Denham is civil for most of the game. When you speak to him face-to-face at the end, though, he's become more rude, including using a full F-bomb.
In "Meet the Spy", the BLU Spy drops a Your Mom joke, quickly followed by a (censored) F-Strike. Since the Spy has always been the picture of sophistication, these two combine to be absolutely hilarious.
BLU Scout: What are you, the President of [the RED Spy's] fan club? BLU Spy: ...No. That would be your mother. [produces compromising pictures of the Scout's mother and the RED Spy] BLU Scout: What the?... BLU Spy: Indeed. And now he's here to f-ck us! So listen up, boy, or pornography starring your mother will be the second worst thing to happen to you today.
Touhou Eiyashou ~ Imperishable Night, stage 4 with Marisa/Alice. Due to a bad misunderstanding, best friends Reimu and Marisa wind up having an actually for serious fightnote the source material says they play-fight all the time, but this one was actually serious, and we know things have gotten real when Marisa tells Reimu:
There's one that counts not because of the level of the swear but because of who uses it: Toriel. "Who the hell is Sans?" It's said when you've achieved the best ending, signalling how the tension has completely evaporated.
Bug Flowey one too many times after getting the neutral ending:
Flowey: Quit looking at me with that stupid expression. You're pissing me off.
The Warcraft games don't shy away from milder curses like "damn" or "hell", but the harsher ones can still be surprising:
Sylvanas Windrunner:[to Arthas in Warcraft III] Give my regards to hell, you son of a bitch! Dwarf Rifleman:[after being scolded by Garithos in Warcraft III] They did not pay us enough to put up with that arsehole! Kael'thas Sunstrider:[in WoW] Insolent son of a... let's get this over with! Garrosh Hellscream:[to Sylvanas in WoW] Watch your clever mouth, bitch.
In Wesleyan Tetris, if you answer the credit screen with "I don't really care," the author retorts "Well fuck you, then!"
In the white chamber, though she uses other swear words throughout the game, Sarah uses the F word only once, when she's being shocked in an electric chair and the laser gun beside her doesn't work.
Xenoblade Chronicles 2: Hearing any explicit swear word in a first-party Nintendo game is sure to catch the player off-guard, and this game has several.