The sequence where Samantha accidentally erases everyone else from existence is quite chilling. That chapter does a pretty good job of conveying what it would actually feel like to be the only person in the world. She's scared out of her mind from the total isolation, and starts to panic about how she can't take care of herself and has no idea what she's supposed to do now, and nearly breaks down crying before she manages to find Clarissa and undo the wish.
When Samantha wishes that Judith was her friend, both the book and the episode portray her as a creepy stalker-type, who at one point breaks into Samantha's home in the middle of the night.
In the episode, rather than wishing for everyone to disappear like in the book, Samantha instead wishes they would "buzz off". Clarissa makes this true, all right... by turning everyone into flies. Especially disturbing for anyone with muscaphobia. Also, Judith's wish that she'd be admired by all who see her causes her to turn to stone. Leaving Judith in a possible And I Must Scream situation. And the single crow that lands on top of her head.