Osmosis Jones is about the human body, so it naturally contains gross-out humor and sights that can disgust you.
- At the beginning, Frank grabs his egg from a monkey and eats it after a ten second rule. It even grossed out his daughter.
- Frank opens his mouth wide to see if he got a temp but doesn't swallow his food. To make matters worse, it was shown in both trailers.
- Frank sneezes near pollen onto his hands and gives Danny a high-five.
- In a deleted scene, Frank is picking his nose.
- After Frank swallows some contaminated oysters, he throws up at Ms. Boyd.
- Franks ingrown toe, which he presents barefoot in a restaurant.
- Ozzy has to drink a gross concoction in The Zit that includes something the bartender ejects from his armpit.
- When Frank returns to Ms. Boyd, she's grossed out by his bulging zit. As Osmosis Jones pops the zit, the fluid lands on her.