- In the first scene, a pressman asks Kara if she is Superman's emergency secret weapon.
- Argo's origin blends elements of the comics, Superman: The Animated Series, and the Supergirl live-action feature.
- This panel◊ references Action Comics #262 cover◊
- One of the kids attending Stanhope Boarding School is Wally the God-boy, a character who showed up in Peter David's Supergirl's run. Tellingly, he is one of the few students who don't pick on Linda.
- In issue #2, Linda remembers using her super breath to freeze melting ice cream. She did this in Action Comics #253.
- In the third issue, Supergirl imagines that her cousin launches her into space, evoking the cover of Action Comics #258.
- In the third issue, Mr. Mxyzpltk is seeing images of future events. In one of those images, Supergirl wears a red hair-band. And the sky behind her is red.
- The 'secret chamber' seen in Cosmic Adventures #4 has been seen before ... way back in Action Comics #277.
- In issue #4, Lena reads the beginning of a sign 'Headquarters of the Interplanetary Multidimensional...' In Action Comics #277 we see the same sign completely: Headquarters of the Interplanetary Multidimensional Practical Jokers Club. And their leader is Mr. Mxyzptlk.
- In issue #4, Supergirl imagines she and Lena ride the Supermobile -which made an appearance in Action Comics #481- and fight crime together. Their catchphrase is: "Super Best Friend Powers -- Activate!"
- Superior Girl was the name of a villain in Superman Family #165.
- The fifth issue starts with Kara mentioning a number of adventures including one with a "kid who thought he was a magician" (Action Comics #253), one with 'a kid who could see in the dark' who was an alien prince (Prince Valzorr from Action Comics #263), and one about a werewolf (Kara in Adventure Comics #387 and Superman's Pal Jimmy Olsen #44).
- Linda and Lena's dorm room number is 1958. A poster of Buzz, an enemy-turned-ally of Peter David's Supergirl, is seen hanged up in their dorm.
- Supragirl is a member of the Legion of Super-Heroes, wears a Flight Ring and a classic Pre-Crisis Supergirl costume and she knows Brainiac 5. She also wanted to be called Andromeda (Laurel Gand's codename, a Post-Crisis Supergirl expy).
- Crisis on Infinite Earths reference: Streaky states that The Multiverse itself shall be torn apart by chaos if Supergirl is struck down.
- Stanhope Boarding School is a reference to Stanhope College in the comics.
Mythology Gag / Supergirl: Cosmic Adventures in the 8th Grade