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"I wonder if the mayor's daughter is still alive? I let her escape so I could enjoy hunting her down later... I'm going to enjoy my new trophy. Yes, frozen forever in the pose I choose to give her."

"Six billion cries of agony will birth a new balance!"
Albert Wesker, Resident Evil 5

While many villains in the Resident Evil franchise trend towards Tragic Monster, or are simply too inhuman to pass moral judgement on, there are these major exceptions, who prove that Humans Are the Real Monsters.

All spoilers are unmarked. You Have Been Warned!

Video Games

Albert Wesker
  • In the first game, he sets up his own team, the STARS, to be killed as test subjects for bio-organic weapons, then resurfaces in Code Veronica to make another attempt on the life of surviving member Chris Redfield. In Umbrella Chronicles he kills Sergei Vladimir in order to secure control of the Umbrella Corporation's data; and in Resident Evil 5 he kills his creator Ozwell Spencer, transforms his girlfriend Excella Gionne into a mutated monster, and brainwashes Jill Valentine into fighting her partner, Chris, before trying to kill ninety percent of Earth's population with his new Ouroboros virus, all as part of a scheme to become god of a new world. He also murdered his mentor Dr. James Marcus, and along with William Birkin conducted fiendish experiments on Lisa Trevor (REmake). Wesker is essentially ambition and treachery made manifest, all wrapped up in a trenchcoat and designer sunglasses.

Main Series

  • Resident Evil 2: Raccoon City Police Chief Brian Irons is monstrous in both the original game and the 2019 remake:
    • Original: Irons was accused of raping a university student several times, before getting away with it and becoming Chief of the Raccoon City Police Department. Taking bribes from the Umbrella Corporation and allowing them to conduct experiments on the city's citizens, he would use said bribes to fund his own personal "Taxidermy Sex Dungeon of Evil", filled with bones, surgical tools, acids, and stuffed bodies. When Umbrella's T-Virus breaks free and spreads throughout Raccoon City, Irons decides to use this opportunity to cause chaos and kill people, which includes zombies, innocent bystanders, fellow cops, and the mayor's daughter. Horribly depraved, Irons proves you don't need superpowers or grandiose schemes to be horrifically evil.
    • REmake: Irons is secretly working for Umbrella. A raping, murderous human taxidermist, Irons prefers killing women and having their bodies converted into stuffed dolls for him to admire. Moonlighting as the city's orphanage director, Irons, under Umbrella's orders, has hundreds of children painfully experimented on for the Birkins' scientific research, with most of the children dying. When one of the children manage to escape, Irons has Umbrella soldiers execute every child at the orphanage to cover the company's tracks. Kidnapping Sherry and holding her hostage, he tries to gun her down once she escapes.
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  • Resident Evil 0: Dr. James Marcus was one of three co-founders of Umbrella Corporation and a Mad Scientist without regard for anyone or anything unlucky enough to get in his way. In the late 1960s, Umbrella CEO Ozwell Spencer assigned Marcus to head the company's recently-constructed research center in the Arklay Mountains, which would also be used as a management training facility. Marcus seized the opportunity to use several of the trainees as test subjects for the newly-created T-Virus, which he himself had developed in his lab by mixing the Progenitor Virus with leech DNA. At least 20 people were unwittingly subjected to his experiments, all of whom died and were either sent off to other laboratories for further research or dumped into the nearby sewers. In 1988, Spencer had Marcus assassinated following a decade-long schism between them; however, he was resurrected ten years later when his memories and consciousness were absorbed by his most recent creation, the Queen Leech, which had the ability to control other T-Virus leeches. Through the Queen Leech, Marcus set out to exact revenge on Umbrella. To do so, he leaked the T-Virus under the Spencer Mansion and on the Ecliptic Express, killing dozens of people and partly precipitating the crisis that led to the contamination of Raccoon City itself. He had every intention of causing large-scale destruction— when Rebecca and Billy finally encounter him, he gleefully expresses his desire to destroy the entire world. Callous and amoral, Dr. Marcus's complete lack of humanity predates his transmutation into a literal monster, which merely gave him the means to demonstrate the true and terrifying extent of his depravity.
  • Resident Evil 4: Osmund Saddler, the master of Los Illuminados ("The Enlightened Ones"), reawakens the Las Plagas parasites, infecting multiple villagers before determining the strain works. Injecting himself with a "master" Plaga, Saddler spreads the parasite to the rest of the village, destroying the minds of everyone it comes into contact with and leaving them as Saddler's puppets. Saddler also conducts horrible experiments on those in his clutches and disposes of the corpses by feeding them to Las Plagas infected monsters. However, when children are infected they die painfully due to their bodies not being developed enough to handle the strain. Saddler plans to use the President's daughter to infect her father and from there take over the US and then the rest of the world, infecting everyone with Las Plagas and leaving them as broken shells for him to control while Saddler reigns over the world.
  • Resident Evil 6: Derek Clifford Simmons is the National Security Advisor to President Adam Benford and the one behind the nuclear destruction of Raccoon City. Serving as the Arc Villain for Leon's campaign, Simmons uses the C-Virus to cause the zombie outbreak in Tall Oaks, the place where the President plans to reveal the truth about Raccoon City and the Bio Organic Weapons trade to the world, causing 70,000 casualties. He also forces Secret Service Agent Helena Harper to personally infect the President by holding her sister hostage, threatening to turn her into a B.O.W.; he does so anyway, and frames Helena and Leon for his crimes. Also apart of said B.O.W. trades, he oversees the creation of said C-Virus by subjecting Sherry Birkin to constant experimentation. Simmons also has an obsessive lust for Ada Wong, and when she rejected him, he would use the C-Virus to create a "perfect Ada Wong", experimenting on 12,235 women, with only one, Carla Radames, surviving, causing her Start of Darkness. Finally confronted by Leon and Helena, Simmons tries to justify his actions, only to be called out on his excuses, revealing Simmons to be nothing more than a perverted madman willing to cause needless death just to hold on to his position in power.
  • Resident Evil 7: biohazard: Lucas Baker, the Big Bad of the Not A Hero DLC, was known as the "Bad Seed" of the Baker family. A brilliant, yet sociopathic, inventor who once trapped a childhood bully to starve to death in the attic, Lucas liberated himself from Eveline's control but found he enjoyed his new powers and ability to "cut loose"—regularly capturing others and putting them in his death traps to test them out, Lucas also makes sure it's impossible to escape the traps so even if one solves them, they'll still die painfully. When Chris Redfield goes in, Lucas captures three of his soldiers and has Chris experience their deaths before trying to kill Chris as well. A complete sociopath with no regard for anyone, even his own family, Lucas is a unique glimpse at a twisted, inventive Serial Killer in the world of Resident Evil.


  • Gun Survivor: Vincent Goldman is the commander of Sheena Island on the behalf of the Umbrella Corporation and responsible for creating the Hypnos T-Type Virus. He creates the virus by kidnapping children and torture them for days by extracting the hormone from their skulls while they are still alive and fully conscious. When the children try to escape the island, Goldman proceeds to kill them all and unleash The Virus on the entire island when its populace rebels.
  • The Darkside Chronicles: Alexia Ashford no longer has love for her brother as a part of her personality, the way it was in Code: Veronica, and her evil is cranked up a few notches higher. A Child Prodigy who joined the Umbrella Corporation at the age of twelve, Alexia was also an entitled sadist with a serious god complex. She aided her brother in murdering and experimenting on their father, tortured a classmate to death (and recorded the session) for being almost as smart as she was, and eventually injected herself with the T-Veronica virus, which she planned to use to Ascend to a Higher Plane of Existence. Reawakened from cryogenic sleep in her twenties, Alexia kills her brother for not waking her up on time, transforms Claire Redfield's Love Interest, Steve Burnside, into a monster and forces him to fight her to the death, and tries repeatedly to kill Chris and Claire for no other reason than their presence is at her facility. She reveals that her plan is to infect the world with the T-Veronica virus, enslaving most of humanity to her will. When asked why, Alexia just gloats about how, as a superior specimen of humanity, she deserves to be queen.

Film Series

  • Spence Parks, from the first film, is a member of Umbrella Corporation's security force and the one responsible for the outbreak. Overhearing his lover Alice and an activist planning to expose Umbrella's illegal activities by stealing the T-Virus, he decided to steal the virus himself and sell it on the Black Market so that he and Alice can spend the rest of their lives in luxury. To prevent the theft from being discovered, he purposely causes an outbreak inside the laboratory so that the A.I. system puts the whole place under lockdown and kills the whole staff. Having temporarily lost his memories as the side effect of a knockout gas, he's found by a squad of Umbrella soldiers sent to investigate the incident. Eventually, his memories return and he holds the remaining survivors at gunpoint, while trying to convince Alice to join him. When she refuses, he locks them up and leaves them behind to die, showing that he cared more about the money than about his lover.
  • Dr. Alexander Isaacs, the Big Bad of The Final Chapter and the Greater-Scope Villain of the entire series, is an Evil Genius who murdered his kindhearted colleague Dr. Marcus for the T-Virus when he realized its potential as a weapon. Experimenting on the innocent, Isaacs later gained delusions of godhood and opted to release the Virus at large while freezing himself and the few "chosen" in cryogenic hibernation in order to later rebuild the world in his image. The end result was a mass extinction event of the world and the deaths of most of the human race. Isaacs leaves his own clones to clean up, aiming to exterminate any survivors. When he awakens, Isaacs promptly attempts to kill the heroine Alicia "Alice" Marcus as well, intent on maintaining the ultimate power he's betrayed and murdered to achieve.

Other Media

  • Biohazard: The Wicked North Sea Light Novel, by Kyū Asakura: Countess Mylène Beardsley is the seventeenth head of the prestigious Beardsley family and a woman with an immense superiority complex. An enhanced human, Mylène constructed a laboratory under her castle to conduct unnecessary experiments on villagers and her servants. Having infected Kate with the Neo T-Virus, Mylène tries to trick Rain into consuming a soup with human eyeballs. In an act of rebellion against Umbrella, Mylène broke her experiments out of containment and released a nerve gas on her own guests. Fancying herself as a being "superior in everything from brain to appearance", Mylène's ultimate goal was to stand at the top of Umbrella and control the world. A rich, teenaged low-functioning psychopath whose methods were questioned by Umbrella itself, Mylène was an example of how dangerous sadism and narcissism can be if combined in one single person.
  • Biohazard 2 manhua:
    • The man only known as "God" is the president of the Umbrella Corporation who desires the destruction of the world by any means necessary. Unleashing the G-virus onto Raccoon City and turning everyone into zombies, he uploads his brain into a parasite once news of Chris Redfield storming his headquarters arrives, and orders his staff members to commit suicide. Retreating to the artificial islands, he sets up a cyborg gladiator ring and unleashes a poisonous gas onto the entire audience once he's been found by the BHST. Taking control of his supposed friend, Inzaghi, he sends his squad to infect multiple parts of the island with his virus, infecting countless innocents. Having kidnapped Leon's father and making him the terrorist assassin known as the Hardened War General, he orders him to infect multiple parts of the island with the G-virus, including Leon himself. Taking BHST prisoner, he reveals that he had cloned the deceased Ada Wong to be his bride, ordering her to kill Leon and herself when the former arrives to stop him. Duking it out with Leon, he destroys an entire city while looking for him, and combines with him to become the ultimate life form, where he attempts to nuke the world to achieve his dreams of an apocalyptic wasteland.
    • Brian (Irons), like his game counterpart, is a violent rapist secretly working for Umbrella. As a child, he would capture rabbits and dissect them for fun. Using his position as Commissioner of the Raccoon City Police Department, he shuts down STARS after the Spencer Mansion incident to cover Umbrella's tracks and leads the massacre of several Umbrella scientists in order to take out William Birkin. Ordered to keep Amy Chan safe, he instead kills her and plans to keep her as a trophy. Capturing Claire Redfield, he shows her his room containing stolen human organs—hoping to add hers to his collection—and has Leon thrown into a room with Lickers.
  • Biohazard 3: Last Escape & Supplemental Edition manhua: "Boss" is a senior executive at Umbrella placed in charge of the T-virus program. Capturing innocent people and having their families murdered, Boss transforms these people into Tyrants, seeking to expand on William Birkin's scientific studies. When one of his scientists, Leo, tried leaving Umbrella, Boss had his friends murdered and imprisons him for decades. Once Nemesis/The Sniper invades Umbrella headquarters, Boss casually lets his cohorts get killed and escapes in a helicopter. Seeking to make more profit, Boss decides to clone various people and sell them for money, ordering Claire's death once he's been found out.
  • Resident Evil Vol. 2 comic, by Ricardo Sanchez et al: Neuermann Giesel is a T-Virus-enhanced clone of Arms Dealer, Fritz Giesel, created by Fritz to help him run Giesel Industries. Fritz places Neu in charge of developing black market Bio Organic Weapons, which Neu creates by painfully transforming the residents of numerous Übelandian towns into monsters whose abilities he showcases to a Uradorian warlord by having the creatures massacre various villages along the border of Übelandia and Urador. Neu also arranges for viral specimens to be exposed to cosmic radiation, which results in deadly outbreaks on both a space station and in Grezbekistan. When the Bioterrorism Security Assessment Alliance begins investigating Giesel Industries, Neu has his "pet" monstrosities slaughter several members of the BSAA team sent to search the Giesel Estate, whose domestic staff Neu abandons to die in the carnage while he escapes to his BOW factory in Urador. Neu tries to starve the pursuing BSAA agents of reinforcements and supplies by overrunning all nearby towns and BSAA bases with zombies, and when the agents try to blow up his factory, they discover that Neu has designed it with a Dead Man's Switch that will cause pockets of BOWs that are hidden throughout the major population centers of Übelandia to activate and rampage, dooming the country and potentially all of South America. After the agents manage to thwart the switch and destroy the factory, Neu makes one final attempt to kill them by mutating into a Tyrant.
  • Resident Evil: Degeneration: Dr. Frederic Downing, a member of WilPharma, is the one behind the events of the movie. Previously a scientist for Umbrella Corps who stole samples of the t and G-viruses before Raccoon City's annihilation, he planned to sell them and a vaccine through the black market as controllable, profitable bioweapons, later unleashing them on various countries as a way to pitch them to potential buyers. Finding a buyer in the form of General Miguel Grandé, he unleashed the t-virus onto Harvardville Airport that resulted in a zombie outbreak, blew up several vaccine trucks to disguise the incident as a terrorist attack, blew up a WilPharma building to kill Claire Redfield, and injected Curtis Miller with the G-virus, all as a way to create a pitch video for Grandé.


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