While most users usually have a drug of choice, in fiction one sometimes encounters a drug user who is completely undiscriminating in their choice of intoxicant. They are so keen (or desperate) to get high, that they will take any substance that offers them a chance to do so. Often Played for Laughs if the substance they are snorting (or smoking, ingesting, imbibing, or injecting) is not a narcotic at all.
A common variant is a drunkard who will drink anything remotely alcoholic to get drunk, even those that aren't meant to be potable.
- In the Se7en comic books series, Theodore "Victor" Allen (AKA the future Sloth victim) is a drug dealer who has a habit of Getting High on Their Own Supply, to the point that John Doe can recognize four distinctive signs of long-term addiction just by looking at him: pockmarks from crystal meth, speed-induced deterioration of bone mass, the erosion of nasal cartilage due to cocaine, and the needle scars from heroin use. For good measure, he drinks very heavily while celebrating his acquittal.
- In Transmetropolitan, Spider Jerusalem, being a future version of Hunter S. Thompson, will take any and all drugs he can get his hands on, especially when he's having a bad day, which is often.
- Steve McCroskey in Airplane!, as revealed in a Running Gag (but at least he's trying to quit):
Looks like I picked the wrong week to stop smoking. [lights up]
Looks like I picked the wrong week to quit drinking. [takes a swig from a hip flask]
Looks like I picked the wrong week to stop taking amphetamines. [downs some pills]
Looks like I picked the wrong week to stop sniffing glue. [has a snort, collapses out of shot]
- A borderline case occurs in The Cannonball Run with Dr. Nikolas Van Helsing. He keeps injecting himself with a syringe whose contents are unknown (to the viewer). When The Alcoholic Jimmy Blake asks him if it's good to drink, Van Helsing replies "Dunno. Never tried" and immediately squirts the contents of the syringe into his mouth.
- The Con is On: Peter is not only The Alcoholic but a completely undiscriminating drug taker. He buys a tray of random drugs off the dealer in the club; takes whatever pills his wife Harry hands him, usually without asking what they are; and swallows an entire bottle of prescription medication he finds in Gina's pocket.
- Fear and Loathing in Las Vegas: Raoul Duke (Hunter S. Thompson's Author Avatar) and his friend "Dr. Gonzo" bring a gigantic valise loaded to the gills with all kinds of drugs for their journey to Vegas, and at one point (while Duke is tripping so hard that he hallucinates Dr. Gonzo slowly mutating into a devil) they argue the idea of testing fresh pineal gland... as in cut someone's brain to get the gland and chew on it.
- Heaven Knows What: Harley and her fellow homeless junkies will gulp liquor, sip on Dayquil, do benzos, shoot heroin, and take pretty much anything else they can get their hands on.
- John Hurt's character in Midnight Express is a heroin addict, but as he's unable to get his hands on the real stuff in a Turkish prison, he's reduced to improvising alternate sources of opioids. In his introductory scene, he's mainlining gastroenteritis medication for the codeine.
- Naked Lunch kicks off with the discovery that William Lee's drug-addicted wife has started using his bug powder as a substitute drug. Lee himself proves no slouch in this department, beginning with the bug powder, then moving on to "The Black Meat," an opioid powder derived from giant centipedes; then, when Lee's source in the Interzone goes missing, he's forced to move onto a local Moroccan hashish resin spread just to deal with the withdrawal. And then he starts drinking the fluid that emerges from the skull-mounted penises of the alien head that has replaced his typewriter. It's worth noting that this film was loosely based on a book that was written entirely under the influence.
- In Trainspotting, Renton notes that whilst not on heroin, he and his friends are busy looking for just about anything with similar effects. After going through some of the NHS sources relied upon in lean times, he rattles off a long list of substitute opioids to be used when not in possession of real junk, including things like anti-vertigo medication.
Renton: Fuck it, we would have injected vitamin C if only they'd made it illegal.
- Roland from After the Revolution uses drugs to drown out the Super Soldier implants that reward his pleasure centres for hurting and killing people: If the drugs are already making him feel good, he doesn't need to harm people to feel good. Roland will therefore drink, consume or inject practically anything that can get him buzzed, and because of his superpowered metabolism he needs either lots of a single drug or mixtures of multiple drugs that complement each other.
- The Andromeda Strain: One of the two survivors of the titular biological hazard is Peter Jackson, the town drunk of Piedmont, a man who is often so desperate to purchase booze to stave off the pain of his bleeding ulcer (and so poor) that he has taken to drinking stove alcohol. His body chemistry is so shot from the constant drinking that Andromeda can't survive it (because it can only work within a very slim degree of blood acidity).
- Discworld: In The Truth, Mr. Tulip is very keen to take drugs. However, he never manages to get his hands on any genuine drugs and ends up snorting everything from curry powder to cleaning products.
- The Hunger Games: Haymitch was once so desperate for a drink, he went to the Hob and purchased rubbing alcohol to drink. Katniss and Peeta panicked and went to stop him, realizing that drinking pure alcohol would blind him.
- Life's Lottery: In one particular plot thread, main character Keith Marion can be introduced to pot and begin a Descent into Addiction that features him indulging in almost every illegal drug known to humanity over the course of his life. After a long period of pot, he moves on to LSD to banish the Shadow Spiders that haunt him, then has to start using amphetamines to cope with the workload at college, then escalates to cocaine in order to cope with the new high-flying professional life that follows, loses everything and becomes hooked on heroin, before finally settling into the Addled Addict phase of his life with crack.
- The Magicians: while at Brakebills, Eliot's drugs of choice are restricted to fine wines and Merit cigarettes, but after graduating, he starts drinking just about anything he can get his hands on. After watching his friend slowly going to pieces over the next few months, even Quentin has to comment after finding Eliot mixing vodka with dayquil note .
- Neuromancer: Case spends most of his free time after Wintermute upgrades his pancreas trying to find something that can still get him high.
- Brad Cohen of Repeat is normally a habitual pot smoker. However, after finding himself trapped in an infinite loop that always ends with him restarting his life from the womb onwards, Brad becomes a full-blown hedonist in order to cope with the Time Loop Fatigue: in his latest lifetime, he admits to having indulged in weed, amphetamines, Ecstasy, heroin, cocaine, tranquilizers, LSD, tequila mixed with absinthe, raw hash, and liquid psilocybin - which he once had injected directly into his penis.
- In Euphoria, Rue's addictive personality is so profound that she'll take just about anything that comes in a pill bottle, to the point that after she nearly overdoses on fentanyl in the second episode, her dealer flat-out refuses to sell her any more drugs.
- The Farscape episode "Throne for a Loss" introduces the Tavleks, a gang of extortionists hooked on a powerful stimulant. After one of them is captured during a botched raid on Moya, Zhaan tries to rehabilitate the guy, and after a while, he almost seems to be responding positively... right up until he trashes one of the DRDs and tries to jerry-rig a substitute drug from its fluid components.
- In The Good Place, Mindy St. Clair died with a cocaine habit and has spent all of her years in the afterlife pining for it. At one point, she pleads with the main characters to bring her "something I can snort. Eye shadow, crushed up baby aspirin, cocaine...".
- Sherlock: In "The Lying Detective", it is revealed that when Sherlock Holmes needs to get really high right now he has no preferences, he will just take whatever he can get his hands on (when he's just casually using, he stick to nicotine patches). His brother Mycroft, knowing this fact and having no way to stop him, only asks Sherlock to keep a list of what he takes in case he ever needs medical assistance.
- Star Trek: Deep Space Nine: Over the course of "The Wire", Garak is revealed to have been coping with life on the station by means of an anti-torture implant that floods his body with endorphins. However, after two years of continuous use, the implant finally breaks down and Garak is forced to make do with any substitutes he can get his hands on until replacement parts arrive, resulting in him drinking his way through about half of Quark's stock of kanar. After being hospitalized due to a seizure, he steps up his efforts by stealing sedatives from the infirmary — and taking near-fatal doses. In both cases, Garak barely feels anything and makes it clear that this means his body is now terminally dependent on the implant.
- In Succession, Kendall's lapses back into substance abuse compel him to consume any drug he can, whether that's meth at a house in New Mexico or ketamine at a secret party in New York.
- Klaus Hargreeves of The Umbrella Academy (2019) is well-known for his habit of abusing drugs of any kind available - partly in order to stave off his visions of the dead but mostly out of sheer hedonism. In his Establishing Character Moment, he's implied to have overdosed on heroin; in a flashback sequence, he's seen rolling joints under the dinner table; he dismisses Ben's suggestion of eggs for breakfast by remarking "you can't smoke eggs"; Hazel and Cha-Cha steal some hash chocolate from his belongings; he's seen taking pills before Ben stops him... and finally, when none of the others are available, he hits the booze hard.
- "The Wine Song" by comedian/folk singer Martin Pearson pokes fun at the pretensions of wine connoisseurs and is sung from the perspective of a completely undiscriminating alcoholic:
Then there's the kind of fellow
Drinks champagne to make him mellow:
Swears by Cliquot, Bollinger, and Brut.
Well, I tried some Brut myself,
I found it on the bathroom shelf,
And he's right, it got me mellow as a newt.
- One of the core traits of Eminem's Slim Shady character is that he is rampantly addicted to any substance you can name - from heavy-hitters like crack and smack, to softer social drugs like weed and ecstasy, to trashy drugs like glue, Vicodin and ephedrine supplements. One radio edit of "My Name Is" even has him getting high off Kool-Aid.
- Generally speaking, the main characters of Grand Theft Auto V often end up getting smashed on anything they ingest - knowingly or otherwise. However, Trevor Philips takes the cake: already a meth-head, he's also a recreational huffer, regularly gets shitfaced on beer or scotch, drinks gasoline during a mission intro, ends up doing all the drugs in a stolen van full of medical supplies, and can often be found waking up on train tracks with an empty bottle of booze in his hand. The only drug he actively dislikes is marijuana, and that's only because it's not a hard drug and (as he sees it) a drug for weaklings.
- Exploring the Ages of Myst reveals that Sirrus has a taste for vice - in contrast to his brother Achenar - and doesn't play favourites in his intoxicants of choice: his luxurious throne room in the Mechanical Age is fitted with its own wine cellar, empty bottles are scattered around his bed in the Channelwood Age, and his palatial bedchamber in the Stoneship Age conceals a number of suspicious-looking vials and syringes.
- Che Garcia Hansson of The Secret World doesn't play favorites when it comes to drugs: during lean times on Solomon Island, he'll make do with pot; immersed in the nightlife of Tokyo, he makes his way through "mountains of dope," and when that's not available, he gets completely smashed on whatever booze is available until he gets kicked out of the club. And then he brings out his little bio-vials of spiders...
- The Investment Banker of Streets of Rogue needs to take drugs once per minute, or he will enter Withdrawal state and take continuous damage. You can take any drug to satisfy your drug need, from cigarettes, sugar, some unknown syringes, or cyanide pill.
- The Demoman of Team Fortress 2 is shown using various substitutes for his typical alcohol: a deleted scene in one of the comics has him willingly inject himself with the Sniper's caustic sedative, one item's description mentions he drinks wood alcohol (something usually added to keep people from drinking chemicals with alcohol in them), and one taunt has him chugging whiskey and the contents of a grenade.
- Disco Elysium: A character with high Electrochemistry will have the latter skill constantly buzzing in his ear to try literally every drug they come across, regardless of status (i.e. egging on to lick spilled alcohol in a table or smoke discarded cigarette butts).
- In The Most Popular Girls in School, Jenna has been known to take weed, Ecstasy, and later cocaine in Season 4.
- Not Always Legal has a story of an unseen addict who stole a businessman's briefcase and snorted the white powder that was inside, without bothering to check what it was. Turns out, it wasn't a drug of any description; it was super-absorbent. The hospital returned the businessman's briefcase, but he never did get back those samples he'd planned to show at a conference.
- Err of Aqua Teen Hunger Force is such a nicotine addict, he attempts to get high by inhaling the Ominous Fog the Cybernetic Ghost of Christmas Past from the Future summons when telling his stories. It seems to work (via placebo if nothing else), and Err even claimed it tasted like menthol.
- Sterling Archer is incapable of functioning unless he's in a constant alcoholic haze. In order to maintain the haze, he's occasionally had to get creative about sources of alcohol; in one episode, he tries to get loaded on barber's germicide.
- His mother Malory as well. When the agency was visiting a space station, she (as well as Sterling) was unhappy to find out there was no alcohol on board. She tried making her own drinks by mixing Tang with rubbing alcohol.
- Cheryl's go-to drug is usually huffing glue but she occasionally dives into other narcotics, including gummy bears laced with LSD.
- In Clone High, supposedly recovered drug addict Larry Hardcore boasts that when he was still in the throes of addiction, he would have smoked raisins if he thought they would get him high.
- Foxxy Love of Drawn Together runs over her four bandmates while drunk on a Gargle Blaster cocktail. Given how hard Foxxy is shown to party, she probably can't get buzzed on anything remotely normal anymore.
Foxxy: [picking up the phone] I need to call an ambulance! Oh, girls, I am so sorry. I never should have been drinking and driving. That is the last time I mix liquor and beer and cough syrup and Kool-Aid and grape Kool-Aid and Lemon Pledge! [in confessional] And this time I mean it!
- One joke in Family Guy showed the Cookie Monster trying to freebase cookie dough in a bathroom stall with a spoon and a lighter, all while anxiously mumbling that it's taking too long.
- In Inside Job Andre is first introduced huffing chemtrails and in a later episode is shown with a briefcase full of multiple types of drugs, including a live toad with hallucinogenic skin secretions. After his drugs are thrown overboard he resorts to licking his sentient mushroom coworker for psilocybin.
- Rick of Rick and Morty is largely an alcoholic, being regularly encountered swigging from a hip flask and sporting dozens of empty bottles rattling around inside his spaceship. However, given that he's also an amoral hedonist, he will gladly make use of numerous party drugs - plus some things that might not have been intended to be used as drugs, including brake fluid, crushed-up crystals, the fluid used to defrost a test subject, and alien pheromones (as smoked through a hookah).
- The Simpsons:
- At the height of Krusty the Clown's opulent lifestyle, he admits to inhaling moon rocks. All it does at that point is help him get to normal.
- Barney is primarily an alcoholic, but when shot with a tranquilizer dart in "Much Apu About Nothing", he pulls it out to drink the rest of the liquid inside.
- In "The Mansion Family", Moe's barflies are so desperate for booze, he fends them off with a whip until the ship they're on crosses into international waters. Lenny asks for some rubbing alcohol for a cut, and Moe obliges. Lenny immediately starts drinking it, and Moe whips it right out of his hand.
- The Venture Bros. had an episode where Sgt. Hatred, desperate for an alcohol fix, was on the floor of the bathroom spraying generic brand body spray into his mouth.
- In the American Dad! episode "I Am the Walrus", Jeff and Hayley are held hostage by Principal Lewis who forces them to clear his house. Jeff has a bunch of pills that cause paralysis (stolen from Roger), but as they are planning how to trick Lewis into taking them, he appears, takes the pills from Jeff, says "What's that, drugs? I'll take it, I don't care what it does!" and swallows them.