A lot of superpowers come with weaknesses. A good Kryptonite Factor can add danger and drama to a story, and as comic books have become more self aware plenty of authors have taken to exploring the Logical Weakness for their characters.
And some writers take it further, where the drawbacks of being superhuman are for all intents and purposes a disability all unto themselves.
Contrast with Disability Superpower, where the disability caused the superpower instead of the superpower causing the disability. Also contrast Disability-Negating Superpower, where a superpower effectively gets rid of a disability.
See also Blessed with Suck, Heroic RRoD, Power at a Price, Required Secondary Powers, Logical Weakness, Power-Upgrading Deformation. Cast from Hit Points, Cast from Lifespan and Cast From Sanity are subtropes.
- Shunsuke from Charlotte has the ability of Mental Time Travel, but it degrades his eyesight with every use. By the time the series starts, he's been rendered completely blind and can no longer use his ability (since light needs to be entering his eyes in order for him to activate it).
- Shion Pavlichenko from Darker Than Black is a Contractor who has the ability to create anything. As with all contractors though, he has to pay a price for using the power. In his case he is left unable to walk, and the duration of this disability is proportionate to what he creates.
- In Yuki Yuna is a Hero, whenever the Heroes go Mankai, they sacrifice a part of themselves in a process called the Sange. This sacrifice can involve losing anything from sight in one eye, to their voice, to mobility in both legs.
- Jonothon Evan Starsmore/Chamber, a Marvel Comics character, is missing his lower jaw and a fair chunk of his chest (only his own powers are keeping him alive) from the result of his powers manifesting.
- Downplayed with Cyclops of X-Men: Because he can't innately control his Eye Beams powers, he can't see well; he has to wear a ruby-quartz visor to limit it and allow him to see "normally".
- The Boys: During a screening of superpowered children (that strongly resembles child beauty pageants), one little girl's eyes melt out as she tries to show her powers, all the while screaming that she's sorry.
- The supervillain Taskmaster is capable of perfectly imitating any move that he's seen. Unfortunately, this takes up most of his short-term and long-term memory, to the point that it's questionable whether he can still remember his own name.
- In NYX, Bobby Soul can temporarily possess other people and absorb their memories, but every time he uses this power, he loses huge chunks of his own memory, to the point that he once became a near-complete amnesiac.
- In New Mutants, Prodigy can unconsciously absorb the collective skills and knowledge of anyone and everyone around him, but he can only retain that information for as long as the people who originally held it are around him. This effectively forces him to study twice as hard as everyone else, because he can't rely on his own personal knowledge base remaining constant.
- Deadpool: Deadpool's Healing Factor comes with the unpleasant side effect of accelerating his already present tumor growth, causing all of his skin to always be scarred and blotched. It's also suggested that his insanity stems from his brain being constantly damaged by tumors before healing over in an endless cycle.
- Thor (2014): Every time Jane Foster transforms into Thor, it has the side effect of negating the effects of whatever chemotherapy she has had since the last transformation, meaning that her powers cause her to slowly succumb to her cancer.
- The Golden Voyage of Sinbad. Prince Koura visibly ages each time he uses his black magic. By the end of the film he's an old man. Luckily for him the treasure he's searching for can give him back his youth.
- The Butterfly Effect: Evan starts suffering brain damage when he uses his time-travel ability to change his life, as years of memories from each alternate timeline fight for space. In the alternate ending, he commits Heroic Suicide before the damage is too great.
- Soon I Will Be Invincible features several examples. The only one which directly affects the plot is Doctor Impossible's Malign Hypercognition Disorder (which some characters say isn't real anyway). The most severe is Rainbow Triumph, who needs a strict regime of medication to stay alive. Crosses over with Disability Superpower as her powers are artificial and were created when her father's company tried to fix her birth defects.
- In The Witcher, gradual infertility is an inevitable side effect of magic use, which is a blessing for some (they're free to fool around with no danger of little accidents) and a curse for others, such as Geralt's Love Interest Yennefer of Vangerberg: she wants children but is long past the point of no return, and ends up becoming a surrogate mother for Geralt's foster daughter Ciri instead.
- Worm has the Case 53's, or Irregulars, which are powered individuals left deeply disfigured in one way or the other because they were used as test subjects for Cauldron's Super Serum.
- Redwall: Badger Lords have the Bloodwrath, a berserk rage that lets them fight through horrifying injury and lose all sense of strategy, plowing through armies they don't even see to reach their hated enemy. In Lady Cregga Rose Eyes' case (so named because while the Bloodwrath causes Glowing Eyes of Doom, hers was always on), it caused her to go blind after her final battle.
- In The Cinder Spires, etherealists' powers come at the cost of Sanity Slippage as the etheric currents eat holes in their minds. Most develop strong compulsions that "fill the holes" and help them concentrate, and might become lost and incoherent if their compulsion is denied.
- Characters in the Marvel Cinematic Universe who gain Inhuman powers often acquire a deformity or disability at the same time. For instance, Gordon gained the power to teleport and lost his eyes.
- In Alphas Every Alpha has a disability alongside their powers. Bill's Uninhibited Muscle Power comes with a heart condition. Gary can sense radio but is autistic. Rachel's super senses are easily overwhelmed. Kat has perfect muscle memory, but no conscious memory beyond the last month. Anna can understand any language but she cannot speak.
- Warhammer 40 K: Psychically empowered humans are very often completely insane, as their powers come from the daemon-filled dimension of raw emotion called the Warp.
- In Eclipse Phase asyncs develop psychic powers as a result of an extraterrestrial nanovirus rewriting sections of their brains, the process also leaves them with at least one mental disability, often two.
- Drakengard: Pact partners lose something when making a pact with a supernatural creature, which links both lives together and allows the two to communicate telepathically. Some are physically disabling (Caim lost his voice, Arioch her fertility, Leonard his sight), some metaphysical (Inuart lost his musical talent, Seere lost his ability to age past six years old), and some aren't exactly hard to live with (Verdelet lost his hair, though his pact partner has since been petrified).
- In The Elder Scrolls series, the eponymous Elder Scrolls are a cross between Tomes of Elditch Lore and Tomes of Prophecy and Fate. Referred to as "Fragments of Creation," the Scrolls are of unknown origin and number which simultaneously record past, present, and future events irrefutably; what did happen, what could have happened, what might yet happen. As such, a reader can gain immense knowledge by reading the scrolls, and even predict the future to a degree. However, without proper training, merely glancing at one will cause immediate blindness, and even with said training (such as the kind members of the Cult of Ancestor Moth receive), a reader will gradually lose their sight with each reading until they're completely blind. (Essentially a play on the Blind Seer trope.)
- Laser Pony from League of Super Redundant Heroes has Eye Beams as a superpower, but his eyes have been fried ever since the first time he used them. His blindness is a major source of gags.
- In Sorcery 101:
- In Batman Beyond, repeated use of the Venom injection has turned Bane into a frail wheelchair-bound cripple.
- Sapphires in Steven Universe can usually see the future. One Padparadcha Sapphire we meet instead sees the past, and only the past, which mostly results in her having a Delayed Reaction to everything.