When space westerns decide to get literal with the genre name, these guys tend to show up.
They are usually depicted as, well, southern-fried semi truckers that happen to fly cargo spaceships instead. Usually easygoing, unflappable, and have a backwoods wisdom developed during the time spent alone on long hauls between solar systems. Occasionally they're smugglers, but usually aren't drug mules. From time to time, between hauls they'll stop at a local tavern and challenge various folks to a little arm-wrestling, drinking contests and then drunken brawls. Tend to talk in a Southern or slight Texan drawl.
Their ships are most likely Used Future pieces of junk, just barely held together — bonus points if they're blocky, and bear a surprising resemblance to modern Mack trucks or other 18-wheelers.
Often a subtrope of Intrepid Merchant.
- Cowboy Bebop: The episode "Heavy Metal Queen" focuses on hunting a wanted space trucker named Decker. Another episode features a group of small time Space Pirates who make a living by robbing other space truckers.
- Zone of the Enders: ''Dolores, i' - Main character James Linx runs a cargo ship around the Sol system. He copes with the boredom of weeks-long journeys with beer and reading.
- Space Dandy: In one Alternate Universe, Dandy is a Dark-Skinned Blond Johnny Bravo Expy and the Aloha Oe is his truck. QT and Meow are there too, the former being a green Cyber Cyclops and the latter being a fanservice-laden Cat Girl with Larynx Dissonance.
- 2000 AD's Ace Trucking Co. series.
- While less of a trucker and more of a taxi driver, DC Comics has Space Cabbie, who has been shown transporting and imparting wisdom to everyone from Adam Strange to Ultra, the Multi-Alien.
- The mostly-forgotten (for good reason) Marvel hero Razorback had the mutant power to drive any vehicle seemingly by instinct. He happily moves up from semis to FTL spacecraft.
- The 2010 The Infinity Gauntlet mini-series includes the character U.S. Ace, whose Space 18-Wheeler (it looks like a semi-truck with rocket boosters) is the fastest ship in the galaxy, and therefore the chosen ship for The Avengers to use to get to the center of the universe. (U.S. Ace is a non-trademarked version of U.S. 1, a character Marvel created in the '80s for a licensed comic to promote a toy truck line. In the '80s comics his truck was "merely" tricked out a la James Bond.)
- Wonton Soup: The main character is a highly skilled chef who decides to wander the galaxy as a space trucker.
- The crew of the Nostromo in Alien.
- Dark Star provides the probable Ur-Example, with John Carpenter and Dan O'Bannon intending to create a foil to 2001: A Space Odyssey by replacing Humanity's Finest with a bunch of stupid hill-billies IN SPACE!. Dan O'Bannon would go on to re-use this motif in the later Alien
- Spaceballs (a parody of Star Wars) naturally has Lone Star (a parody of Han Solo) driving a Winnebago through space.
- Space Truckers. You don't say. Right down to the spaceship looking like a Mack truck.
- Battle Beyond the Stars: Space Cowboy is a character like this, down to his broken-down cargo ship with a Confederate flag on the hull. He even watches old westerns on long hauls, and plays the harmonic.
- For all intents and purposes, Han Solo in the first Star Wars film, at least when the audience first meets him. He'd normally have turned down the heroes' request for transport, except he was hard up for cash after having to dump a big cargo of illegal goods. Circumstances prevent him from repaying his debt which finally comes back to bite him at the end of the second and beginning of the third films.
- In John DeChancie's Skyway trilogy, the only widely known form of faster-than-light travel involves driving ground vehicles along the highway/Portal Network Precursors have built which seems to connect every place in the universe worth visiting. Most races don't even bother building sublight spaceships (though they do get used), and if anybody has actual FTL space drives they're keeping it very quiet, so trade equals truckers. And human truckers tend to be... well, truckers.
- Endemic in The Expanse, where jobs to transport water and resources between the outer colonies and Earth/Mars are vital but not very highly regarded. The protagonists (Jim, Naomi, Alex and Amos) begin the series as this, hauling water for a private company between the asteroid belt and Jupiter's moons.
- Chakona Space: Contributing author Allen Fessler has given us Neal Foster: Interstellar Freighter Captain. Foster's Backstory even includes an actual 18-wheeler.
- In Lucifer's Star, the crew of the Melampus are this when they're not functioning as Space Pirates. The ship is a Star Galleon and contains a town-sized amount of cargo space. Its crew is also halfway between a Ragtag Band of Misfits and an Army of Thieves and Whores on its best days.
- The Eureka Maru in Andromeda is this before its captain got hooked up with the Andromeda. Their contacts still come in handy.
- Neelix was this in Star Trek: Voyager before joining up with the Voyager. He was initially portrayed as a much savvier spacer before going through Flanderization to become Plucky Comic Relief.
- The Star Trek: The Next Generation episode "The Outrageous Okona" had the Loveable Rogue variation in Okona. He is also an Expy for Han Solo, so this is to be expected.
- Firefly: The crew of Serenity have this as a major part of their job. Of course, they also do burglaries and mercenary work.
- "Asteroid Named Rest Stop", a song by Julia Ecklar and Leslie Fish. The lyrics can be found here
- Mojo Nixon has "UFOs, Big Rigs, & BBQ." Apparently UFOs are driven by long-haul truckers.
- The aptly named board game Galaxy Trucker. Corporation Incorporated needs a way to transport low-cost housing and sewer construction equipment to new colonies. What is the cheapest way to do this? Let people weld it together into random spaceships and fly it across the galaxy in exchange for getting to keep any profits they manage to earn along the way.
- Free Traders in Traveller, though there the preferred analogy is of "tramp" (non-scheduled) ocean freighters than of truckers; even a free trader costs enough for any one who owns one free and clear to be counted as pretty wealthy.note
- The roleplaying game Bulldogs! has the player characters as delivery messengers in the vein of Futurama—with the "expendable employees" Black Comedy turned Up to Eleven.
- Elite, its sequels and the many, many games that followed its example start from a basic premise of "A Space Trucker Is You". Over time, the concept expanded to the point where the player may also be an explorer, a military fighter, or a venture capitalist with real estate of their own.
- The X-Universe series allows the player to take up the role of a freelance trader, along with the thousands of AI traders. Most TS (Transport, small) class ships have modular cargo sections like a freight train. Several of them have elements of modern trucks - The Argon Mercury has a sun visor and a cockpit reminiscent of a Mack truck. Others resemble oceangoing cargo ships, with containers being the bulk of their mass and the cockpit protruding slightly above them roughly 2/3rds of the way from the front, like a ship's bridge.
- TL (Transport, large) ships, however, don't reference pre-space age designs and consist basically of a single humongous container with engines attached. Justified as they need to carry very bulky goods like space station assembly kits.
- While StarCraft was established as being the Deep South IN SPACE!, StarCraft II takes it even further, with all the music being country, the SCVs being truckers, and advertisements for "Bubba's Gas and Grits", a restaurant with an actual space truck on it.
- In EVE Online, a player can train industrial ships and become one of these, hauling others' goods around. Red Frog Freight is a particularly well-known player corporation that specializes in this.
- Space Run is about hauling goods between space stations. Instead of piloting your ship, you build and direct defenses to fend off pirates with Tower Defense style gameplay.
- On the 3DO game Loadstar: The Legend Of Tully Bodine, you play the titular space trucker as he runs through the maglev trenches of the Moon ferrying an illegal cargo that must be taken to Mars. The game itself is a Rail Shooter with Full Motion Video.
- This will be one of the possible occupations in Star Citizen's MMO-style persistent universe.
- Rebel Galaxy combines the same sort of space trading simulator as the above games with a rusted Used Future aesthetic and soundtrack full of country music.
- One episode of Futurama has a space trucker convoy. Their role in the story was basically just to throw cat calls at Leela.
- The main characters themselves work for a delivery company, making them non-stereotypical truckers in Space.
- The Planet Jackers from Invader Zim are quite reminiscent of long haul truckers.
- The Vreedle Brothers from Ben 10: Alien Force and beyond talk and dress like stereotypical truckers; even their spaceship looks like a truck.