Take one existing show genre, add another, and presto! you've got a brand-new genre.
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Anime and Manga
- High School Drama + Lighthearted Comedy + Harem Genre + Shounen + Every Magic Trope Imaginable + Every Science Fiction Trope Imaginable X Serial Escalation = Mahou Sensei Negima!. You may think that's an exaggeration. You would be wrong.
- High School drama + Humongous Mecha + Moe + Star Crossed Lovers + Transformation Trauma + Dysfunction Junction + Tear Jerker + Downer Ending + Kill 'em All + Nightmare Fuel Fridge Logic = Saikano
- Magical Girl Warriors + Devices from Humongous Mecha + Shounen Combat + Surprisingly Dark Plot + The Military + In Space = Magical Girl Lyrical Nanoha
- Magical Girls + Toku + Softcore Cinemax Skinflick = Ultimate Girls
- Girls' Love + Humongous Mecha = Kannazuki no Miko
- Mind Screw + Humongous Mecha + Viewers Are Geniuses + Eldritch Abomination + Rule of Symbolism + Dysfunction Junction + Deconstruction + Nightmare Fuel = Neon Genesis Evangelion
- High School Sitcom + Boy Meets Girl + Sci-Fi + Slice of Life + Locked Room Mystery = The Melancholy Of Haruhi Suzumiya (anime). Well, yeah.
- Magical Girl Warrior + Gender Bender = Mahou Shounen Majorian
- The Western + Hammer Horror + After the End = Vampire Hunter D
- Gentleman Thief + Coming-of-Age Story + Steam Punk = The Daughter of Twenty Faces
- Magical Girls + Nightmare Fuel + Faustian Rebellion= Puella Magi Madoka Magica
- Magical Girls + RPGs + Humongous Mecha = Magic Knight Rayearth
- Lolis + Mind Rape + unreliable narrators + The Power of Friendship + What Could Possibly Go Wrong? + Gorn + Moment of Awesome + Awesome Music = Higurashi: When They Cry
- Magic Idol Singer + Wholesome Crossdresser = Brocken Blood
- High school drama + Feudal Future + Knight in Shining Armor + Humongous Mecha + Serial Escalation (Magnificent Bastard + Wham Episode)³ = Code Geass
- Youkai + New Transfer Student + Petting Zoo People + Fanservice + Marshmallow Hell + More Fanservice = Kanokon
- Children Raise You + Coming-of-Age Story + Parents (and Children) As People + Parent with New Paramour + Boys' Love = Sakende Yaruze!
- Tsubasa -RESERVoir CHRoNiCLE- (Shōjo (Demographic) - Mind Screw) + Kingdom Hearts (Disney Princess - Metaplot) = Kilala Princess
- Alice in Wonderland + Mind Screw + Cast Full of Pretty Boys + Dysfunction Junction = Pandora Hearts.
- (Magical Girl + Ballet + Fairy Tales) x (Mad Artist + Rewriting Reality) = Princess Tutu
- Ultraman + (Deconstruction + Anyone Can Die + Crapsack World + Alternate History + Redshirt Army) = Attack on Titan.
- Seltzer and Friedberg + Black Comedy + Medium Awareness+ Deconstruction x Horror Tropes + Joss Whedon + Subtlety = The Cabin in the Woods
- The Silence of the Lambs + Aliens + Stagecoach = Pitch Black.
- Ditto the Sequel, even if it made a Genre Shift: Star Wars + Alien³ + Conan the Barbarian + Matrix = The Chronicles of Riddick.
- Body Horrors + Mind Screw = The Soul Taker
- Gundam + Cthulhu Mythos + that bloke that did Hellboy = Pacific Rim
- Blaxploitation + Our Vampires Are Different = Blacula
- Serial Killer + Buddy Cop Show = Se7en
- Sexploitation/Erotica + Crime Mystery Film Noir + Slasher Movie = Giallo
- Horny Vikings + Instant Awesome: Just Add Dragons! = How to Train Your Dragon
- (Fallout 3 - I Love Nuclear Power) + (The Drifter x Badass Preacher x Disability Superpower) + (The Bible x Can't Stop the Signal) = The Book of Eli
- A Street Car Named Desire + Gender Flip + So Bad, It's Good = The Room
- Government Procedural + Boarding School of Horrors = Gormenghast
- Great Detective + Affectionate Parody + Romance Arc = Lord Peter Wimsey
- Our Souls Are Different + Waxing Philosophic + Rule of Cool + Film Noir with a Bifauxnen Jerk with a Heart of Gold protagonist = Kara no Kyoukai
- Film Noir + Functional Magic + (Badass Longcoat + Genre Savvy + Occult Detective + First-Person Smartass + The Nicknamer) + lots of Shout Outs = The Dresden Files
- (Pokémon + Lost Roman Legion) + Five Races + Succession Crisis = Codex Alera. Super extra bonus points for the ones in brackets not only being this trope deliberately invoked, but the very reason for writing the book.
- Punk Punk settings usually start as Cyber Punk mixed with another genre. For example, Cyber Punk + Medieval European Fantasy = Dungeon Punk.
- Low Fantasy + (High Fantasy - Hobbits) + Succession Crisis + Character Depth + (Noughties Drama Series - Turn of the Millennium) + 27 * Magnificent Bastard = A Song of Ice and Fire
- (Xenofiction - Cats Are Mean + Anyone Can Die + Family-Unfriendly Violence) x (Proud Warrior Race Guy + [The Clan x 4]) x (Long-Runners + Loads and Loads of Characters) = Warrior Cats.
- Weird West + High Fantasy + Horror + Science Fiction = The Dark Tower.
- Dungeon Punk + Comedy = Discworld
- ... + Police Procedural = City Watch subseries.
Live Action TV
- Police Procedural + Prime Time Soap = Crime Time Soap (Hill Street Blues)
- Sitcom + Wagon Train to the Stars = Red Dwarf
- Spy Drama + The Western = The Wild Wild West
- Medical Drama + The Western = Dr. Quinn, Medicine Woman
- Medical Drama + Amateur Sleuth = Diagnosis: Murder
- Medical Drama + Space Opera = Mercy Point
- Medical Drama + Work Com = Scrubs
- Medical Drama + Work Com + During the War = M*A*S*H
- Medical Drama + Rescue = Emergency!
- The Musical + Dramedy = Glee
- Police Procedural + Work Com = Barney Miller
- Police Procedural + Law Procedural =
- Most famously, Law & Order
- ... which was preceded by the short-lived 1971 Jack Webb production The D.A., which used the same basic format.
- ... which itself was preceded by Arrest And Trial, a 90-minute 1963 series.
- Police Procedural + Rescue = Third Watch
- Police Procedural + Odd Couple * Gender Flip + Government Conspiracy * Science Fiction = The X-Files
- (The Western + Sci-Fi = Space Western) + Government Conspiracy = Firefly
- Travelogue Show + Reality Show = The Amazing Race
- Cop Show + Super Sentai = Tokusou Sentai Dekaranger
- Film Noir + Post-Cyberpunk + Kamen Rider = Kamen Rider Double
- Hammer Horror + Kamen Rider = Kamen Rider Kiva
- High School + Kamen Rider = Kamen Rider Fourze
- Coming-of-Age Story + Cosmic Horror Story + Mood Whiplash + Kamen Rider = Kamen Rider Gaim
- Robot War + Police Procedural + Kamen Rider = Kamen Rider Drive
- Medical Drama + Video Game Tropes + Kamen Rider = Kamen Rider Ex-Aid
- Kamen Rider + Humongous Mecha + Romance of the Three Kingdoms = Legend Heroes
- Super Sentai + Americanization + Media Adaptation Tropes = Power Rangers
- Kyoryu Sentai Zyuranger + (Gosei Sentai Dairanger - The Core Five Costumes) + Ninja Sentai Kakuranger + Wake Up, Go to School, Save the World = Mighty Morphin' Power Rangers
- Denji Sentai Megaranger - Video Game Tropes + Space Opera + Rescue Arc + Grand Finale = Power Rangers in Space
- Seijuu Sentai Gingaman + Wagon Train to the Stars + Darker and Edgier = Power Rangers Lost Galaxy
- Mirai Sentai Time Ranger + Adaptation Distillation = Power Rangers Time Force
- Bakuryuu Sentai Abaranger + Wake Up, Go to School, Save the World + TOMMY = Power Rangers Dino Thunder
- Engine Sentai Go-onger - Lighter and Softer + Darker and Edgier + After the End = Power Rangers RPM
- "Die Hard" on an X + Race Against the Clock + Real Time = 24.
- (Heroic Fantasy + Recycled In Space - Two-Fisted Tales) + Walking the Earth + (Shell-Shocked Veteran / [Cool Old Guy x Really 700 Years Old]) + (Timey-Wimey Ball x ∞) = Doctor Who (at least, from 2005 on).
- Wake Up, Go to School, Save the World + Joss Whedon + Dramedy + Angst = Buffy the Vampire Slayer.
- Circus Drama + The Western = Frontier Circus
- Warhammer + SPACE - Cooperation + Oversized Weaponry - Cooperation + GRIMDARK - Cooperation + Chainswords - Cooperation: Warhammer40000
- Cyberpunk + High Fantasy + Strange Combinations + Mercenaries: Shadowrun
- Old World of Darkness - Modern day setting + Eldritch Abominations/Titans + Fantasy Kitchen Sink + Anime= Exalted
- Space Marines + Super Soldiers + Alien Invasion + The Virus + Zombie Apocalypse + Hopeless War + War Is Hell + Military Science-Fiction + Space Opera = Halo
- First-Person Shooter + Le Parkour + Action Girl = Mirror's Edge
- Cute Monster Girls + Bullet Hell + Awesome Music + Fantasy Kitchen Sink = Touhou
- Take part of the above + Serial Escalation= Mushihime-sama
- Metroidvania + Nintendo Hard + Guide Dang It! + Goddamned Bats + Demonic Spiders = La-Mulana
- Retro-futuristic Science Fiction + Underwater Habitat + Hidden Elf Village + Survival Horror + Art Deco + Anarcho-Capitalistic Dystopia + Genetic Engineering Is the New Nuke + What Measure Is a Non-Human? + System Shock = BioShock
- Platform Hell + Nintendo Hard + Ludicrous Gibs + Everything Trying to Kill You + One Hitpoint Wonder = I Wanna Be the Guy
- The Legend of Zelda + Bullet Hell = Engage To Jabberwock
- The Legend of Zelda + Character Customization + Metroidvania + Crapsack World + Nintendo Hard = Dark Souls
- Dark Souls + Gothic Horror + Cosmic Horror Story = Bloodborne
- Kaiju + Professional Wrestling = King of the Monsters
- Raygun Gothic + Zeerust + Eagleland (both flavors) + Alternate History + After the End = Fallout
- Roguelike + The Legend of Zelda + Nausea Fuel + Nightmare Fuel + Thick-Line Animation = The Binding of Isaac.
- Dragon Quest + Monster Girl Encyclopedia = Monster Girl Quest
- Humongous Mecha + Lovecraft Lite = Demonbane
- 4X + Real-Time Strategy = Rise of Nations
- First-Person Shooter + Puzzle Game = Portal
- Final Fantasy XIII + Chrono Trigger = Final Fantasy XIII-2
- Pinball Quest does this with all of its games:
- Fighting Game + Role-Playing Game + High Fantasy + Partially Civilized Animal + Lauren Faust = Them's Fightin' Herds
- (Deep-Immersion Gaming x 11) + Les Yay + The Plan+ Corrupt Corporate Executive + Moral Event Horizon4 + Sliding Scale of Idealism vs. Cynicism / Loads and Loads of Characters - Rule of Cool + Shown Their Work = KIKEN
- Archie Comics + Superhero School + Crazy Awesome + Transgender = Whateley Universe
- Redwall + Zootopia + Usagi Yojimbo + Princess Mononoke + Alternate Universe + Beast Fable + What Do You Mean, It's Not for Kids? = Tasakeru
- Any random movie + Winnie-the-Pooh + Any other nostalgic character + Railroading + Dull Surprise + Captain Obvious + Hey, That's My Line! + Forgot About His Powers = Poohs Adventures
- The Runaway Guys - 1 = Game Grumps
- Let's Play + MST3K = Retsupurae
- ([Teen Drama x (Homage + The '90s)] + Elaborate University High) + ([Video Games x Sports Stories] x Serious Business) = Video Game High School.