Alice has been spending years of her life focusing on a single great project, putting most or all of her leisure time and free money into it. Finally, it's approaching completion...but just before she can reveal it to the world at large, an unlikely and destructive chain of Disaster Dominoes and violent intruders conspires to utterly wreck everything she has accomplished. Cue Big "NO!". Or if you're looking to mix it up, Angrish. Specially if she had No Plans, No Prototype, No Backup.
If a villain is the victim of this, be prepared for a vicious and frighting Villainous Breakdown.
- In How to Make an American Quilt, the protagonist's dissertation on quilting traditions gets blown away by an aggressive storm. She's pretty cheerful about it, though, because she's learned that love is more important than work. Or something.
- Similarly, in Wonder Boys, Michael Douglas' character feels pretty good about losing the several thousand pages of his second novel, probably to indicate that it didn't measure up to his brilliant first one.
- In the first Dennis the Menace movie, Mr. Wilson spent forty years growing a plant that only flowers once for a few seconds. So he invites the neighborhood to the flowering, but Dennis causes a distraction at the crucial instant by screaming that Mr. Wilson's house was being robbed. Thinking Dennis was Crying Wolf, Mr. Wilson then lays into Dennis with a Tranquil Fury-laden "The Reason You Suck" Speech, which leaves Dennis in tears and runs away in sadness. However, Dennis was telling the truth, and even ends up at the robber's mercy later.
- In Twice Upon a Time, Synonamess Botch drives his head nightmare writer Scuzzbopper to attempted suicide (and a Heel–Face Turn) by dismissively throwing his manuscript for a "Great A-Murk-ian Novel" out a window.
- King Triton destroys Ariel's collection of salvaged treasure in Disney's The Little Mermaid after finding out that she was secretly in love with a human prince.
- Amy burns Jo's manuscript in Little Women. It's clearly stated that Jo spent years (she's fifteen) of her life on this thing and that it's irretrievable as Jo destroyed the original manuscript after copying the stories to the one Amy burns.
- A more benign variation occurs in The Moomins, where a philatelist ruins his ability to add to his collection of every stamp in the world ever by finishing it (ignoring the fact that new stamps are always being issued somewhere in the world). After a bout of depression he becomes a botanist.
- In C. M. Kornbluth's short story "The Mindworm" (about a psychic vampire), the main character walks in on an artist who has finally set aside the time to undertake his Magnum Opus and unceremoniously smashes the raw material he painstakingly acquired. Apparently emotional states were like flavors, and he wanted a unique dish.
- In the Knight and Rogue Series Ceciel spends her whole life experimenting to find a way to give humans magic. When she finally succeeds her test subject responds by trashing her lab, wrecking all her potions and burning all her years of notes before managing to convince her she failed anyway.
- In A Clockwork Orange, Alex and his droogs shred the manuscript of F. Alexander's book A Clockwork Orange. Alexander rewrites the book from scratch; within two years it has been published.
- An episode of Blackadder the Third centers on Baldrick's unwittingly destroying Dr. Samuel Johnson's life's work, the very first English dictionary. Johnson is, of course, enraged...until it turns out the manuscript that Baldrick burned was Blackadder's life's work, a novel that he'd spent over seven years writing. And then at the end of the episode, Baldrick really does toss the dictionary into the fire.
Blackadder: Thank you, Baldrick — seven years of my life up in smoke. Your Highness, would you excuse me a moment?
Prince George: By all means.
Blackadder: (leaves the room) OH GOD, NO!! (returns) Thank you, sir.
- Played with in an episode of Reno 911! where an author's novel manuscript is trapped in a burning building. He pleads with the cops to go in and save it, but they want to know if it's any good first. He describes it, but it turns out it's a derivative knockoff, and they let it burn.
- Played for laughs in a British sketch show starring ex-Goon Michael Bentine. A guest on an interview show has spent ten years building a magnificent model of St. Paul's Cathedral out of matchsticks. Unfortunately the heat of the studio lights cause it to catch fire. The interviewer mutters, "Well, I expect we'll be seeing you again in ten years. Only this time I'd suggest taking the match heads off first."
- In the Midsomer Murders episode "Orchis Fatalis", someone takes revenge on an orchid collector by pouring weedkiller over his priceless orchid collection. This being Midsomer, things soon escalate to murder.
- The sketch-comedy show Almost Live! regularly featured a kung-fu parody called "Mind Your Manners with Billy Quan"; the fights would sometimes start with the same oaf thoughtlessly destroying Billy's latest painstaking masterpiece. The bulk of every episode involved Billy beating up the oaf in a deliberately cheesy martial arts duel as punishment for violating whatever rule of etiquette the episode is about.
- In a Wings episode, Lowell shows Joe the model blimp he's spent years creating and makes Joe promise not to play with it. Joe plays it with anyway, and it promptly gets smashed behind a door.
- In Power Rangers Samurai, Serrator spent 200 years preparing his master plan to conqueror Earth and the Netherworld, starting with cursing Deker and Dayu. However, when Deker refuses to comply at the pivotal moment, causing Serrator's 200 year ambition to go down the drain, the Nighlok loses it and goes on a vicious rampage.
Serrator: Two hundred years of planning, ruined in a single instant!
- Columbo: In "Any Old Port in a Storm", the murderer does this to himself. He murders his half-brother by leaving him bound in his wine vault and turning off the air conditioner so he suffocates. However, while he is away, there is an unexpectedly hot day that raises the temperature in the uncooled vault to the point where the wine oxidizes; destroying his priceless collection.
- There's a legend about Saint Albertus Magnus who supposedly had built a working android, which could walk, would do household chores, and according to some could even speak. Albertus' greatest student Thomas Aquinas destroyed it (thinking it was the result of demonic possession), after which Albertus was said to have spoken: "The work of fifteen/twenty/thirty years is ruined." In Latin, of course.
- Hedda Gabler burns the only copy of Lavborg's manuscript, on which he'd staked his future. Unhappiness and deaths ensue. This is Ibsen, after all.
- A major part of Apollo Justice: Ace Attorney involves this: Valant Gramarye has been waiting for seven years to inherit his mentor's magic tricks. Turns out they passed on to someone else. And he finds this out on the day he was due to finally perform them.
- This is Lady Vayle's reason for revenge against Artix in AdventureQuest Worlds and DragonFable. She had dedicated her entire life in the pursuit of necromancy in order to bring her brother back, but thanks to Noxus being a dick and Artix destroying the crystal that had her brother's spirit orb inside after having to destroy the Monster from Beyond the Veil that her brother's body had become...yeah.
- In the Interactive Fiction game Damnatio Memoriae by Emily Short, you have very limited time to hide or destroy all evidence of your supernatural powers before your room is searched. One of the damning pieces of evidence is your book, years in writing, that describes faraway lands (which you couldn't have possibly written without using your magic.) If you don't manage to hide it, other options are either to destroy it (at which point the character bleakly remarks he'll never be able to muster up the energy to write it again) or magically change its apparent authorship, so that someone else is credited for your life's work.
- Misfile: An angel misplaces two years of Emily's life that she'd spent working incredibly hard at school so she could get accepted to Harvard. Now she'll just have to do it all over again!
- Sarda of 8-Bit Theater has a habit of doing this to people, when he does it to himself.
- Helen and Micah first met in Mac Hall when he accidentally jumped off a balcony and just barely missed landing on her semester project.
- In The Inexplicable Adventures of Bob! Jean Poule is of two minds about this. On the one hand, the destruction of her grand experiment produced Molly the Monster, her adoptive daughter who she loves dearly; but it also crippled her scientific career.
- In a episode of The Simpsons, Bart ended up destroying George Bush Sr.'s memoirs.
- Homer says this word for word at the beginning of "The Wettest Stories Ever Told", when he figures out the pattern of the wall decor and Lisa points out a break in the pattern.
- All of those times an Ancient Egyptian is making the final few taps on the nose of the Sphinx, only to have a chase go by and make him make ONE too many taps. Poor nose!
- Batman: The Animated Series plays this for the tragedy it actually is when Mr Freeze, after his body decays beyond use and leaving him a disembodied head, costing him the last hope he had, sets out to make everyone else as miserable as he is by destroying their life's work. The cases we see has him destroy a painter's masterpiece and an archeologists greatest discovery.
- Avatar: The Last Airbender: "MY CABBAGES!!!"
- The Legend of Korra: "MY CABBAGE CORP!!"
- Spongebob Squarepants's crashing into a truck loaded with fruit punch ruins an old guy's memoirs which were written with red ink.
- Garfield and Friends: A "Screaming With Binky" segment featured a diamond cutter who spent decades studying the Klopman Diamond to figure out where to hit it to split it in half, turning it into two priceless gems and one wrong move would instead turn the diamond into a worthless pile of dust. Well, it was ''Screaming With Binky" so, does any troper need to write what happened?
- In the I Am Weasel episode "The Legend of Big Butt", Weasel shouts this when he discovers that Loch Ness Monster, like his last expedition, was a hoax by the Red Guy. Ironically, him ranting hysterically about it makes him miss the actual Nessie showing up behind him, alongside Santa Claus, the Abominable Snowman, the Easter Bunny, the Tooth Fairy and a UFO.
- In the Christmas Episode of Danny Phantom, this was the trigger for the Ghostwriter's attack against Danny, for destroying his Christmas poem, but also because he didn't feel any real remorse over it.
- Subverted in Real Life with Sir Isaac Newton. In his early career he was not very good at getting himself published, he tended to just let the finished work pile up on his desk. One day his dog knocked over a candle and much of his life's work up to that point went up in flames. So he sat down and wrote it all out again. "Diamond! Thou little knowest the mischief thou hast done!".
- Sadly not subverted when Erich Bessel-Hagen gave his mathematics thesis to his friend Carl Siegel to review it. Siegel decided to go over the thesis while he was taking a boat trip, but he didn't like it, so he tossed it overboard. Mind you, this was many years ago, so it's not like he had a copy saved on his computer. Bessel-Hagen did later manage to receive his doctorate, but still.
- Alfred Russell Wallace was a Victorian naturalist whose work parallelled Darwin's. In 1848 he began a 4-year expedition to the Amazon collecting plant and animal specimens. In 1852 he took ship back to England with his collection. Four weeks later the ship caught fire. The crew abandoned ship but most of Wallace's collection was destroyed. At least it was insured.
- DeathOnAStick, who spent a year and a half on a single game of NetHack, spending most of that time collecting rocks, transforming them into gems, putting them into bags, and creating pet giants to hold the bags full of gems. Then he accidentally drank a cursed potion of gain level, which moves you up a dungeon level, which put him past a Point of No Return. Without his gems.