A substance that grants Invisibility when applied to something. Usually, it is invisible ink or vanishing cream, despite the fact these real-life items do not grant invisibility at all.
Alternatively, a character applies the substance on himself/herself yet remains visible, but thinks he/she is invisible.
- Muppets from Space: One of Bunsen's recent Muppet Labs inventions was a rubber ducky that released an invisibility spray when squeezed; Kermit and the gang uses this as a means to sneak into the Covnet facilities to rescue Gonzo, however, Fozzie washes his hands after using the bathroom, washing the spray away from his hands, leaving them to appear as a pair of floating hands. When the spray wears off shortly afterward, we see Fozzie was picking his nose, Piggy was chowing down on a bag of potato chips, and Pepe was dancing ballet in a tutu.
- Inverted in The League of Extraordinary Gentlemen with Skinner, who is The Invisible Man. He's always invisible and he puts on ordinary white cream make-up so we can actually see him.
- This is the MacGuffin of Now You See Him, Now You Don't. Dexter Reilly attempts to create one of these and succeeds due to a lab accident. Unfortunately, a group of gangsters find out about it and steal the formula to perform a bank robbery which leads to a car chase with an invisible car.
- In the The Zack Files episode "Gone", the gang are exploring lemon juice as an invisible ink with Gwen's diary being written in it. Zack feeling thirsty drinks some of the lemonade used for ink and ends up turning invisible himself. However he develops resistance to the lemon juice over time and keeps regaining visibility, forcing him to drink a higher dose of lemon juice with each instance.
- An episode of Mopatop's Shop featured an invisibility machine that sprays an unidentified substance onto objects to make them invisible.
- Used in King's Quest VI: Heir Today, Gone Tomorrow to fool the last of five guards who each represent one of the five senses. The apparently empty inkwell makes Alexander invisible long enough for the guard's keen vision to tell him there's no one present.
- In The Flintstones Season 3 episode "Invisible Barney", Fred has Barney drink a concoction he mixed up in his garage lab to get rid of his hiccups. While it does make Barney's hiccups go away, it also makes Barney do the same, as in, become invisible. Hilarity ensues, especially over at the bowling alley when a rival challenges Fred to a game, and Barney is "down at the pins" fixing the game in Fred's favor.
- Tom and Jerry
- "The Invisible Mouse": Jerry hides in a bottle of invisible ink to avoid Tom. Once he jumps out, he sees his lower half gone. After being initially shocked, he realizes the effects of invisible ink and goes to apply more on the rest of his body.
- "The Vanishing Duck": the aforementioned duck, along with Jerry, apply vanishing cream, making themselves invisible for most of the short. It ends with Tom having used that same cream on himself, making himself invisible so he can pursue them.
- Looney Tunes:
- In Water, Water Every Hare, Bugs Bunny turns himself invisible by pouring a bottle of 'vanishing fluid' over himself. After various hijinks, the Mad Scientist restores him to visibility by pouring a bottle of 'hare restorer' over him.
- In "Cheese It, The Cat!", in order to sneak to the refrigerator to get a cupcake for a birthday party, Ralph Crumden covers Ed Morton in "invisible ink." It doesn't make Morton invisible, but as long as he thinks he is, he does not fear the cat. Morton gets the cupcake and eventually eats it, leaving no recourse but for Ralph to get another but not before he has Morton cover him with "invisible ink." Ralph can still be seen and when he goes out, the cat attacks him. And it's Ralph who calls Morton "a mental case!"
- One Foghorn Leghorn cartoon has Fogie putting vanishing cream on Henery, then making him believe that he's invisible. Henery uses his "invisibility" to gang up on the Barnyard Dawg, but he's not convinced.
- During the episode I Just Don't Get It on KaBlam!, Henry and June give the studio a thorough Spring Cleaning, with Henry doing the pair's laundry... using an industrial-sized bottle of Disappearing Ink as detergent. June makes it off-screen just before she loses her undershirt and shorts, Henry... gets locked out.
- One episode of Rugrats has Angelica cover herself in "vanishing cream" when it seems that Tommy and Chucky, who only had a little bit put on, were actually invisible. What she hadn't known was that Didi convinced Drew to essentially ignore Angelica when she starts doing bad because she was just trying to get attention. However, his ignoring worked a little too well and, when Angelica couldn't get the dried up make up off of her, she began fearing that she was forever stuck invisible. When Drew saw how much Angelica was remorseful for what she did, he dropped the act and took her home to get her cleaned up.
- Rocky and Bullwinkle: In a "Mr. Know-It-All" segment about how to remove a mustache, Bullwinkle puts mustache remover on. Then Rocky tells him it isn't mustache remover, it's vanishing cream! Cut to Bullwinkle's mustache, sans Bullwinkle, floating in air. "Now he tells me!"
- In Fraggle Rock, the Gorgs use radishes to make anti-vanishing cream, which keeps them from vanishing. This only appears in one episode, then never mentioned again.
- Cow and Chicken: In "Invisible Cow", Red Guy sells what he claims to be invisible sauce to Cow, which she actually believes makes her invisible, so she frolics through town doing as she pleases, even though she's in plain sight of everyone else. In the end, Red Guy decides to sell fat sauce instead, which he uses on Chicken, and it actually works; Chicken then asks for some invisible himself so people won't see how fat he is, but Red can't find where he put it, since it's invisible.
- Spongebob Squarepants: In "Pranks a Lot" Spongebob and Patrick bought an "invisible spray" from a toy store. After they fought each other over the usage of the spray, they accidentally sprayed themselves with it, making them invisible. After accidentally scaring off a random bystander, they decide to pull a prank on everyone in Bikini Bottom - a prank in a scale so big that it gets in the news.
- SheZow: the title character can use vanishing cream to turn invisible for a while.
- The Donald Duck short The Vanishing Private has Donald discovering an experimental "invisible paint" and using to camouflage an Army cannon. He then gets it all over himself and uses his invisibility to drive Sergeant Pete crazy.
- One episode of Futurama has the Professor invent a ray that turns ink invisible in order to rid Fry of an Embarrassing Tattoo, unfortunately it's even more painful than a regular laser removal. And then it happens to hit Zoidburg, who's soaked in his own ink, making him completely invisible, convenient as he was running from the Robot Mafia at the time.
- An Al Brodax Popeye cartoon has Wimpy making himself invisible with vanishing cream to escape Brutus' wrath. Popeye gets into the act to help Wimpy yank Brutus' chain.