There's this character in a show named Bob who is a little different from everyone else. Maybe his personality is a bit quirky, or perhaps he's abnormally short compared to everyone else, or maybe he has a third arm. The other characters wouldn't mention it (or maybe they will), but one episode there comes a time where Bob gets annoyed or embarrassed at his differences. Luckily though, 10 episode minutes later it just so happens that the cast gets themselves stuck in a situation where said difference comes in useful and only someone with said difference actually is able to solve their predicament. Ooh, how convenient.
This trope comes up either for a bit of character development for Bob, or as an Aesop of sorts towards the audience where the lesson is "Be Yourself" or "Don't be ashamed if you're not like everyone else".
Compare Bunny-Ears Lawyer, The Wonka, and "Flowers for Algernon" Syndrome. See also Disability Immunity, Disability Superpower, Heart Is an Awesome Power, Necessary Fail. Sister trope to This Looks Like a Job for Aquaman.
- In One Piece, Usopp's pessimism means that he isn't affected by Perona's Negative Hollows, which send everyone else into a Corner of Woe. He even manages to make the ghosts themselves depressed.
- Asterix: Cacofonix the village bard's legendarily off-key singing (which can make it rain indoors) means he's often attacked as soon as he opens his mouth, but there are several occasions when he's weaponized.
- Asterix and the Normans: The Normans don't know what fear is and are looking for someone to teach them (they hear it gives men wings and want to acquire this power). At the end of the story, in recognition for his role he's seated at the village feast while Fulliautomatix is the one tied up.
- The Mansions of the Gods: To persuade the Romans to desert the Mansions, the Gauls rent an apartment for Cacofonix, telling him that this way, he'll be allowed to practive his singing without the Gauls telling him to shut up, not to mention he'll be surrounded by the refined and cultured Romans. The Romans clear out the next day.
- In Asterix and the Magic Carpet, an Indian fakir comes to the village after hearing rumors of a man who can cause rain by singing, and takes Cacofonix, Asterix and Obelix back with him to solve the drought of the Ganges.
- In Benjamin Harper's The Lion and the Mouse and the Invaders from Zurg, Thunder prohibits mice from joining the Alliance because they're small and fragile. He eats his words when he's taken captive by the aliens and only Daisy is small enough to infiltrate their ship and free him.
- Good Omens: When trying to prevent a computer from starting World War III by launching nukes, Anathema hits on the idea of using Newton's uncanny ability to destroy any electronics he touches by trying to improve them. He looks at the computer, start moving things around so they'll work better, and before long the day is saved.
- The children's book Betty Lou Blue is about a girl who is made fun of for her very large feet. But when her peers sink into a snowbank, Betty Lou is able to save them because her feet act like a natural pair of snowshoes.
- The Sarah Jane Adventures. "Secrets of the Stars" begins with Luke upset that he doesn't have a star sign since he wasn't born in the normal sense, but his lack of a sign is what saves the world when they have to battle an astrologer controlling people through astrology.
- In Earthbound, Jeff is the Badass Normal who lacks the use of PSI and instead has to rely on machinery to replicate the effects of it. Since he has no Psychic Points he's completely immune to attacks that drain PP or disrupt PSI attacks, so any enemy that uses one on him will end up just wasting their turn. It also means that, while his machines are never as effective as their PSI counterparts, he can use them as much as he wants for no cost. Duster repeats this in Mother 3, trading machines for a myriad of thief tools that replicate PK moves for free.
- Freefall has Blunt, who suffers from an extremely low clock speed after encountering a solar flare. This keeps him planetside, forces him to speak in a very. Truncated. Manner. And also allows him to fend off the "Gardener in the Dark" program.
- Vespa Ilkay of The Penumbra Podcast suffers from psychosis as a result of her radiation poisoning, and constantly experiences vivid hallucinations. This ends up being an asset in "Juno Steel and the Shadows on the Ship", when the Carte Blanche is attacked by a shapeshifter. Because she's spent so long learning how to distinguish her hallucinations from reality, Vespa is the only person who's able to correctly determine who her real crewmates are and who is the impostor.
- Rudolph the Red-Nosed Reindeer: Everyone made fun of Rudolph for his 'condition' but on Christmas it was his red nose that saved it.
- American Dad!, "CIAPOW": Director Bullock believes humans are flawed and machines can do a better job. Later though, when the guys have to escape prison their flaws (as Stan puts it) are what saves them.
- Garfield and Friends: One "U.S. Acres" segment had Sheldon upset that he wasn't as tall as everyone else, but then all the characters get stuck in a silo and the only way to get out is through a tiny hole which only Sheldon fits through.
- Gravity Falls: In "Irrational Treasure" Pacifica makes Mabel feel ashamed at her silliness, but when she and Dipper try to find out the real founder of Gravity Falls, said silliness helps them follow the clues left behind by said founder (who was an even bigger Cloud Cuckoolander than Mabel).
- In Sabrina: The Animated Series when everyone ends up inside Harvey's comic book world, Sabrina's power is to make squids shoot out of her hands. It seems pretty useless until Harvey's draw-it-and-it-comes-to-life pen gun runs out of ink and Sabrina remembers what squids are good for...