A character has undergone a complete physical sex change, usually through magic or Applied Phlebotinum.
For some this might be a positive experience; for the Escapist Character experiencing life as someone of a different gender can be a new adventure or Wish Fulfillment for the audience, and for the character who is not comfortable with who they are, the Second Law of Gender Bending will often lead them to their personal Happy Ending. Not so this character.
The character will not be happy at all with the new condition. There might be any number of reasons for this. Maybe they were just about to marry with their True Love. Maybe they didn't receive the benefit of Attractive Bent-Gender. Perhaps it was just a case of being happy with the old gender and they simply aren't comfortable with their current body. Whatever the specific issues they may have, the Gender Bender situation will result in angst, conflict, etc. for the character.
Depending on how much (and how quickly) the character's appearance changes it can be hard to prove that they're even the same person, which can cause them to lose their friends, their family and their job. And if there's a Cosmic Retcon or Fake Memories to prevent this, then it could result in people talking about a past that the character doesn't remember, or friends acting like strangers or vice versa, causing the character to question their sanity.
There's also the case of a man who's proud of his strength, who gets turned into a woman and angsts over no longer being able to fight properly. This could be treated as simply "men are stronger than women", or with more nuance as "his new body has different muscle distribution and range of motion, which aren't in sync with the way he learned to fight" or "his fighting style relied on a Gender-Restricted Ability he no longer possesses". Or maybe it isn't sex-related at all, and his new body is simply a "baseline" one that hasn't been through the same physical conditioning as his old one.
Compare to Trans Tribulations.
- Mai Natsume of BlazBlue: Remix Heart was a guy who accidentally became a girl because of an artifact. As she had to live with other girls in the Academy's dorms, she feared that she might be "losing himself" because she acts more and more like a girl; at the same time, however, she doesn't want her friends to know her condition. By the end of the manga, however, she realized that this new life has given her more happiness that when she was a guy, so in the end Second Law of Gender Bending is played instead.
- Inside Mari is about a college man who gets trapped in the body of a high school girl he is in love with. He is deeply unsettled by it at first, partially because he's in a female body and partially because he puts Mari on a pedestal. He couldn't even look at her naked body for a long time while either bathing or undressing. When Mari averted the No Periods, Period rule, Isao completely freaked out. Subverted as no body switch occured. Mari suffers from Dissociative Personality Disorder and there's no body swap going on.
- In the manga series Kagerou-Nostalgia, Ranmaru, formerly a woman, was transformed into a man by the series' Big Bad before the story even began and now serves as one of his two Dragons, changing back to a woman once a month. This is a problem for her partner, Rikimaru, who had a huge crush on her female form. They're now forced to serve together as Heterosexual Life-Partners, and the situation destroys their relationship.
- In Punchline Yuuta switched bodies with a girl ten years ago. He hates it and still lives as a boy.
- Ranma ½: Although Ranma Saotome can revert to being male as readily as he becomes female, he considers his female form an insult to his masculinity, strongly dislikes the male suitors it attracts, and eventually has to worry his mother will make him kill himself because of it. Although he eventually learns to use it to his advantage (to the point of being comically ready to seduce men in a later manga story), whenever a possibility to remove the Jusenkyo Curse presents itself, he immediately jumps to it.
- In Sekirei Homura deals with being a girl, but she doesn't like it and is obviously still uncomfortable with her growing attraction to her Designated Love Interest.
- The basis of Shishunki Bitter Change. Yuuta and Yui experienced a "Freaky Friday" Flip during elementary school, and never managed to switch back. Not surprisingly, they got desperate to switch back to their original bodies. They got over it somewhat after the Time Skip to their teenage years, but still expressed desire to return.
- Occurs in the Excalibur story where the heroes were subjected to a "Freaky Friday" Flip with their enemies the Crazy Gang. Not only was Meggan not very happy with the Knave's male body, the Knave was really unhappy with hers too. (Although given what he said, it may have had more to do with him not being able to control Meggan's shapeshifting ability than the gender issue.)
- Dungeon Keeper Ami:
"Lady," she began, only to be interrupted immediately as a frown appeared on the troll's face."Lord, Marda corrected, and added "I am male," upon noticing her guest's puzzled expression.The troll's irritation grew as Ami kept looking incredulously at the two prominent bumps bulging underneath the creature's chain mail shirt. "Ignore the body. It is merely the result of a very juvenile curse, the creature said, gritting her teeth. "Mukrezar, may the dark gods feast on his entrails for all eternity, found it so amusing that he made it permanent."Ami stared. "Oh. That must me awkward. Um, he was the Keeper who originally conquered the Avatar Islands, right? I thought he was dead. Shouldn't his magic have faded away?"
- In the My Little Pony: Friendship us Magic oneshot Forever Mare, a mare named Sorrel Lace is transformed into a stallion by Discord's magic. Sorrel Lace lost the foal she was pregnant with. She wants Celestia to change her back, but Celestia isn't able to. In the end, Sorrel ends up committing suicide.
- In The Hot Chick, a "Freaky Friday" Flip causes the bodies of Rachel McAdams (an Alpha Bitch) and Rob Schneider (a petty thief) to switch, causing both angst.
- The title character in Sam is a He-Man Woman Hater who undergoes extreme angst after being transformed into a woman. She even considers undergoing gender reassignment surgery to become male again (an option that's almost never mentioned in most Gender Bender works).
- In Prelude To A Kiss, the main lead exchanged bodies with an old man just before she was going to marry.
- In Chalker's The Four Lords of the Diamond series, the main character has his brain pattern imprinted on four prisoners, each being sent to a different planet in the Warden Diamond Penal Colony. One of the bodies is that of a female. Fortunately for the protagonist, he is going to a planet that has the strange property of switching the minds of two people when they sleep with each other (in the literal sense). He jumps at the first opportunity to get himself back into a male body, and never looks back—even though this inevitably blows his cover.
- In Whateley Universe, Mokele', whose mutation changed him from female to male, hates it. As said in Rotten to the C.O.R.E:
(<Mokele'> Nightshade? It's Mokele'.)(<Nightshade> Yes, dear boy, what is it?)...The subspace communicator tended to give the users a flat, artificial tone to their voice, part of it due to the technology, part of it due to the necessity of sub-vocalization in its use. Never the less, Tatiana heard the anger in the other end of the line and knew her barb had found its mark. (<Mokele'> How many times have I told you...?)(<Nightshade> Get yourself a man if you can't decide to be one on your own, comrade. Either way is of no difference to me.)
- In Tamir Triad, Tobin was magically turned into a boy as a baby and raised as male to avoid her Evil Uncle. Growing up she felt loneliness and some confusion, such as when she wanted to go play with dolls but was told that boys don't play with dolls. Things got more confusing as she aged.
- NYPD Blue: The Victim of the Week was a surgeon and it turns out that he had perfromed a sex change operation on a baby after a botched circumcision. The 'girl" grew up depressed and not fitting in until she was told the truth by her parents, at which point she got another sex change operation to become male again. The surgeon tracked him down and wanted to write a book about his (alleged) success; the man's father killed the surgeon after having previously threatened to kill him if he came near his son again. Likely inspired by the case of David Reimer.
- Tip from Emerald City was turned into a boy as a baby using magic. He's transformed back as a teenager but he's shown very uncomfortable with living as a girl. He still sees himself as male.
- In The Who song "I'm a Boy" the narrator can't wait to resume his normal sex role.
- Eerie Cuties: Because of the Tiersias Orb incident, Ace was stuck as a girl from the end of vol.0. He began to adjust to it, but still expressed concern about whether he'd ever regain his own body. Which he finally did, at the end of vol.1.
- Misfile: An error in the Celestial Bureaucracy alters history so that Ash was always female and only he remembers otherwise. While Ash has gradually become more accepting of the situation, s/he is still deathly afraid that he will remain a girl forever. Though being a girl no longer causes angst, 'he' is afraid of growing too complacent with the new state. A lot of Ash's angst comes from the fact that, while the reality where he is female has some major upsides (he is much closer to either of his parents, and becomes friends and later lovers with Emily, who life was similary altered), suddenly changing to a new life and body causes major dysphoria.
- In The Order of the Stick Roy doesn't seem to terribly mind being female for a dozen strips or so (it helps him get perspective on the kind of person Miko Miyazaki is), but he'd much rather have his "Trouser Titan". The fact that he's just as bald female as he is male probably also helps.
- El Goonish Shive: Unsurprisingly given just how much gender-bending there is in this comic, this trope does come up a couple of times.
- Justin definitely identifies as a man, but when he is temporarily turned into a woman for a party, he finds himself torn between how unnatural it feels on the one hand, and how as a woman his being attracted to guys would be seen as normal and he'd even have a chance with Elliot on the other.
- Elliot is not happy when Tedd turns him into a girl, and when he finds out that he's going to be stuck like that for a month he's willing to sneak off into a secret government warehouse and use a mysterious cursed artifact to try and get back to normal.
- He doesn't take it much better when complications from the cursed artifact wind up forcing him to turn into a girl and back several times a day for the better part of a year, not to mention needing to sleep as a girl.
- In the Codename: Kids Next Door episode "Operation C.A.R.A.M.E.L", it's revealed that Heinrich Von Marzipan turned evil as the result of a magical gender change without the benefits of Attractive Bent-Gender.
- In the Futurama episode "Nutopia", the Planet Express crew runs afoul of an alien who strips them all of their sexual characteristics and then, while trying to restore them, accidentally swaps everyone's genders. Nobody is happy about the change.
- The tragic case of David Reimer: as a result of a botched circumcision, his parents were convinced to give him a sex change and raise him as a girl as part of a psychological experiment. He was very much against living as one from an early age, and later in life, after he'd been told what happened to him as a baby, he underwent gender reassignment to live as a man, but it wasn't enough to prevent him from taking his own life at 38.