Unlike the Fountain of Youth's waters (except for overlaps between the two tropes), the Elixir of Life must usually be drunk to take effect, rather than bathed in.
Said to be related to the Philosopher's Stone in alchemical lore, though this was not always its origins in myths and legends. No Immortal Inertia and/or Rapid Aging are likely to occur if a repeated user stops taking elixir.
- The "spilling from the Fountain of Youth" variety is the macguffin in the Spirou and Fantasio story The Man Who Did Not Want to Die. The titular Man is an old adventurer called Zantafio who found the Fountain of Youth and brought back copious amounts of its waters (the Elixir) in large bottles. Decades later what remained of his supplies is actually lost and he has to return to the Fountain in time before ever-fastening Rapid Aging gets him...
- The eponymous tale by The Brothers Grimm shows Elixir of Life as the only cure for a dying king, said in legend to flow from a magical fountain in a far-away palace. The king sends his three sons to get elixir for him.
- Honoré de Balzac's short story L'Elixir de Longue Vie tells the story of how the father of Don Juan note obtained a phial of Elixir of Long Life that, if rubbed over his freshly-dead body, could restore him to life. The dying man tells Don Juan to use it on him without specifying how. Juan starts to fulfill his dead father's last request but never for a moment believes it will work. When Juan Senior's head starts to twitch, Don Juan is so terrified that he drops the phial, leaving half of his father's body a corpse. Weirdness ensues.
- The 1890 French fantasy novel L'Elixir de Vie, by Jules Lermina, invokes the trope as a Red Herring. It is thought to be the mysterious Mr Vincent's source of immortality before the twist that he is actually a Life Drinker who sucks out children's life force.
- Harry Potter
- The Elixir of Life is mentioned in the series, where it is created (by methods unknown) from a Philosopher's Stone. This version of the Elixir gives health and youth to whoever drinks it, but has to be drunk regularly, as the body will start aging again after each rejuvenation. In the first book, Lord Voldemort mostly seeks the Philosopher's Stone because he wants to use the Elixir to remake a body for himself, hinting there may still be more the Elixir can do.
- Unicorn's Blood also functions as a dark counterpart to the Elixir of Life: drinking it can somehow stave off imminent death by malady, but it carries a curse that will make the body even weaker in the long run. Elixir of Life is said to counteract this curse, though this may just have been a lie Voldemort told Quirrel to get him to go along with drinking Unicorn's Blood.
- The Secrets of the Immortal Nicholas Flamel also has the Elixir be the source of the titular Flamel's immortality. In this version, it is a mystical drink whose recipe is different each month, with the new formulas being found in the self-updating Codex of Abraham the Mage, a mystical tome in Flamel's possession.
- In Doctor Who, the Sisterhood of Karn are guardians of the Elixir of Eternal Life, as seen in "The Brain of Morbius" and "Night of the Doctor".
- Chinese Mythology:
- In traditional Chinese myth, a white rabbit that lives on the Moon knows the secret to creating an elixir that grants eternal life, which it produces by grinding various ingredients together with a mortar and pestle.
- The archer Houyi once shot down the nine suns that were overheating the earth, and was given the elixir of immortality as a reward. However, he wanted to share it with his wife Chang'e, but (depending on the version) she drank it herself/was forced to drink it, and fled to the moon to escape her husband.
- Historically, a common pursuit of Chinese alchemists during the imperial period was the attempted creation of an elixir which would grant eternal life if drunk.
- Hindu Mythology: According to Hindu myth, Amrita — the nectar of life that grants immortality to those who drink it — was created when the gods and demons churned the ocean with a mountain, using the king of the nagas as a rope to move the peak. Amrita was brought to the surface by the churning, and the gods drunk it and obtained eternal life. The demons would have drunk it as well, but the gods managed to trick them and deny them the elixir of immortality.
- Much like their Chinese counterparts, many European alchemists in the Middle Ages sought to create the elixir of life. Often, this was done in parallel with attempting to create the Philosopher's Stone, as the ability to create the elixir of life was one of the many powers given to the mythical stone. A number of historical and pseudo-historical figures, such as Nicolas Flamel and St. Germain, were said to have created the Stone and the associated Elixir, and to have lived for centuries as a result.
- Advanced Dungeons And Dragons 1st/2nd Edition had two versions of this.
- Drinking a Potion of Longevity reduces the drinker's age by 1-12 years. However, each time one is drunk there's a 1% cumulative chance that the effect will be reversed, causing the drinker to become their true age. If this happens to someone who's extremely old, they can die of Rapid Aging on the spot.
- Drinking an Elixir of Youth causes the drinker to become 2-5 years younger, with no chance of side effects.
- Shows up twice in Touhou:
- Eirin Yagokoro came up with the Hourai elixir, which induces complete Resurrective Immortality in the drinker after three sips (the first prevents aging, the second prevents disease), and was banished to Earth from the Moon along with Kaguya. When Kaguya left the Earth, she left the elixir behind and he Emperor ordered it destroyed, but Mokou (whose father had been humiliated by Kaguya's Impossible Task) stole it and drank it herself.
- Junko launched an invasion of the moon to get revenge on Chang'e (her son was killed by one of the suns shot down by her husband Houyi), unaware that the Lunarians had imprisoned her for drinking the Hourai elixir as well.
- In Rayman 2: The Great Escape, Rayman meets a sick-looking Clark at the Menhir Hills. Clark explains to Rayman that he must have swallowed something bad for him, and he needs a life potion, hidden near the entrance of the Marshes of Awakening, in a place called The Cave of Bad Dreams. Jano, the guardian of the Cave of Bad Dreams, won't let you in if you don't know its name. After defeating Jano, Rayman returns to the Menhir Hills with the elixir, and Clark is back to his normal self.
- An event chain in Stellaris allows the discovery of an elixir of life. Production capacity is not enough to significantly raise the lifespan of the entire population, so you have to choose between distributing it anyway (which raises population happiness) or restricting it to your leaders (which increases your empire's "leader lifespan" properly, so you can keep experienced leaders longer).
- In The Dragon Doctors the Fountain of Youth was reverse-engineered to mass-produce rejuvenation potions, with a safety installed so that the furthest back one can be de-aged is to babyhood (the original fountain having no living thing within miles because of this loophole). The potion, detached from the Fountain, is not referred to as Elixir of Life but otherwise fits this trope to a T.
- The Elixir of Life is used as an important MacGuffin in Disenchantment. Princess Bean's father, King Zog, is one of several humans who wants to obtain the Elixir, which is said to be derived from the blood of an elf; he allows Bean's friend Elfo to live in the castle, in exchange for him being used as a guinea pig for magical experiments. Zog's plan is to use the Elixir to resurrect his petrified first wife Dagmar, which eventually succeeds.