Newspaper and magazine comic strips of the 2000s.
- Baldo started its run in April 2000.
- Big Nate continued its run all through the decade.
- The Boondocks continued its run from 1999 until 2006.
- The Lilo & Stitch franchise had a number of comic strips published in Disney Adventures's "Comic Zone" section from early 2002 (months before the original film's release) to 2005 (around the release of Lilo & Stitch 2: Stitch Has a Glitch).
- Cul de Sac began as a Sunday Strip in the Washington Post in 2004, went to daily nationwide syndication in 2007, and ran until 2012.
- Fleep started as a newspaper comic in 2002.
- Foxtrot continued its run all through the decade.
- Frazz was launched in April 2001.
- Max Finder Mystery started in 2002.
- The Outrageous World of Alex and Charlie started in the early 2000s.
- Pearls Before Swine was launched in 2001.
- Pooch Café is the first comic strip of this era, launching in January 2000.
- PreTeena launched at April 2001 and ended in May 2008.
- Scary Gary debuted on June 16, 2008.