Annihilation may refer to:
- Annihilation: A 2004 Forgotten Realms novel by Philip Athans. Book five of the War of the Spider Queen series.
- Annihilation: A 2006 Marvel Comics event.
- Annihilation: A 2014 Sci-Fi Horror novel by Jeff VanderMeer. Book one of The Southern Reach Trilogy.
- Annihilation (2018): A film adaptation of the above, starring Natalie Portman and directed by Alex Garland.
If an internal wick brought you here, please correct it to the appropriate above.
