- The Blind Side: The Tuohy children offer their hands to Michael when saying Grace at Thanksgiving dinner.
- In Transformers, Mikaela slowly reaches for Sam's hand, as they watch the Autobots descend from the night sky. Later, Sam does this to Mikaela as they lie on the ground, just after Starscream fires at them.
- A very heartwarming example in Crouching Tiger, Hidden Dragon, when Mu Bai briefly holds Shu Lien's hand while they are alone.
- In the Harry Potter and the Prisoner of Azkaban film, Hermione instinctively grabs Ron's hand when Harry interacts with Buckbeak. They then look at each other and awkwardly look away.
- In the final scene of Fight Club, Tyler takes Marla's hand as they watch several skyscrapers explode around them. He then looks at her and says "You met me at a very strange time in my life."
- In Star Trek: The Motion Picture, there's a scene where Spock, still recovering from his mindmeld with V'Ger, takes Kirk's hand and tells him, "This simple feeling is beyond V'Ger's comprehension." (This scene is the current page image for Ho Yay.)
- After Knox convinces Chris to attend a play with him in Dead Poets Society, they are briefly seen holding hands during said play.
- Sleepless in Seattle ends with Sam and Annie meeting for the first time, atop the Empire State Building. They hold hands as they head for the elevator.
- In The Hobbit, Galadriel takes Gandalf's hands as she assures him that he has her silent support when the rest of the White Council would not support him or the dwarves on their quest.
- Miao Miao has Ai saying Miao Miao has "sunshine hands" and clasping hands with her at any possible moment.
- Emma: When Emma and Mr. Knightley sit discussing the paths that led them to each other. Later, they even share Intertwined Fingers when they break the news to her father.
- The 'hero and love interest hold hands while fleeing' trope is spoofed in Jurassic World. Owen holds out his hand when running away from one of the dinosaurs, as a gesture for Claire to grab it so they can both run away. She instead just runs past him, making him look like an idiot.
- Star Wars: The Force Awakens. Rey gets annoyed when Finn tries to do the same when they're fleeing the stormtrooper attack on Jakku. This happens twice. On the third instance, Rey is the one who offers Finn a hand. This could show independence but also compassion on Rey's part, as well as No Sense of Personal Space for Finn.
- The Last Jedi: During Rey and Kylo Ren's fourth Force Bond session, Rey reaches out her hand. Kylo reciprocates. They touch hands despite being light years away from each other, and it is probably the most intimate moment of both their lives so far. Rey, at least, even has a vision of the future and Kylo seems to see the truth of her parents. This might be among the most epic hand holding scenes in all fiction.
- Dr. No: When Dr. No invites them to dinner, Bond Girl Honey Rider holds Bond's hand for reassurance, only to notice his palm is sweating as much as hers (it's the first Bond film, so the No, Mr. Bond, I Expect You to Dine trope is freaking them both out).
- Man of Steel:
- In a platonic example, Perry holds Jenny's hand while she's trapped under rubble when the Kryptonian World Engine is destroying Metropolis. Perry could attempt to run to safety, but he chooses to stay with her as the shockwaves from the World Engine get closer so she won't have to die alone. Superman manages to stop the World Engine Just in Time, saving them.
- While Clark and Lois hold hands a number of times in the film, this is subverted when the two of them are taken aboard Zod's ship. Superman appears to hold Lois's hand to comfort her, but he's really slipping her the Kryptonian drive containing Jor-El's digital avatar so it won't be discovered by Zod.
- Wonder Woman (2017): When Diana asks why two people are holding hands, Steve Trevor explains that it's probably because they're together. She takes this as a reason to hold his hand, and he has to stammeringly explain what he meant by "together".
- In the film version of Little Women starring Winona Ryder, Jo and Professor Bhaer share a number of romantic scenes which are not in the book. At the end of the movie, after he has awkwardly proposed and she has joyfully accepted, he protests that he has nothing to offer her and "My hands are empty!" She responds by placing her own hand in his and saying, "Not empty now."
- Tragedy Girls: Sadie and McKayla do this a lot, to show how close and affectionate their friendship is. Used to downright creepy effect when they massacre their entire senior class, and watch the chaos hand-in-hand.
Holding Hands / Live-Action Films