- When Chris realizes that Leona, the Asian woman that he'd been talking to, was really his daughter Marie. One wonders if there was a single dry eye in the theater when the audiences saw that.
- When Chris decides to remain with Annie. Robin Williams' Puppy-Dog Eyes are such a heart-clencher.
- A meta example: Because of the movie's Central Theme of finding happiness in the afterlife even after suffering through various versions of Hell, this film is a favorite of patients in hospice care.
Heart Warming / What Dreams May Come