- While they're all perverts with no internal filters, the fact that Cal, Jay and David all genuinely want to help Andy shed his V-Card is sweet.
- After Andy gets embarrassed from people at work making fun of him for being a virgin and runs out, David is the one to chase after him and try to calm him down, and Andy later shows his appreciation for the gesture. David's got a good heart when he's not a Jerkass Woobie.
- Andy and Trish's whole relationship in general, as well as her acceptance of the truth behind his sexual inexperience.
- Andy bonding with Trish's teenage daughter Marla and helping her realize sex isn't so important, culminating in Marla stating that while she finds Andy to be a dork, she really can see how happy he makes her mother.
Heartwarming / The 40-Year-Old Virgin