- Meru lets out a faint "thank you" for her classmates because they don't forget her even though she (temporarily) loses her quirk at Chapter 289.
- Every single of Nozomu's students waiting outside of his operation room after he was hit by a traincar.
- Kafuka donated organs saving the girls from their Death by Despair and their gradual acceptance of each other as friends.
- Similiarly, the girls (and boys) all move to the island Nozomu left for after their graduation, because he, as their fake teacher, gave them an enjoyable school life and they want to pay him back.
- A single page at the end of several chapters that depicting Chiri and Harumi's childhood flashback are nothing but moments of heartwarming incarnates. There's a reason why these completely different girls that not necessarily understand each other's taste can be friends, after all.
- Harumi, seeing that Chiri playing chutes and ladders alone (with three imaginary friends), offers to play with her because she thinks it's so lonely to be alone.
- Chiri tugging at Harumi's skirt, thinking that she's her Security Blanket.
- Chiri driving off a paedophile from kidnapping Harumi with a shovel when the adults in the vicinity don't give a damn.
- Playing mock "Freaky Friday" Flip, Harumi proceeds to act in-character by cleaning their entire neighborhood. Chiri (blushingly) denies that she's that nice of a little girl.
- Chiri at first didn't want to make friends because she knew that she might move again one day due to her father's job. Harumi tricks her by becoming rivals at random challenges and vow that even if they can't be friends, they will always be rivals and will see each other again to finish their rivalry. Unfortunately, this backfires as they never really declared their friendship after they find out that Chiri's family decided to settle down in that city.
- Around Chapters 150-165, Kafuka, Nozomu, and Chie decide to ride the mystery train together. During their trip, Kafuka asks Nozomu if he's decided on who he's going to marry. He then gives a slight smile and blushes, simply saying "yes". Kafuka later decides to put off losing her virginity. It's a long story.
- In one episode, when Chiri leans about ditzes getting more love and attention, she decides to try being a ditz too so that Nozomu will see her. This being Chiri, it means a lot that she'd try to change her ways for the man she loves.
Heartwarming / Sayonara, Zetsubou-Sensei