- The end of the Area 51 episode, when Penn refrains from insulting the UFO hunters because they're just a bunch of friends having a fun night, comes off as quite sweet—especially in comparison to the show's usual tone.
- The end of the Boy Scout episode, where the scoutmaster admitted he was gay to all six of his "campers."
- From the Eat This episode. Penn vouches for modified crops that can make greater yields and can grow in tougher places. Norman Borlaug, Noble laureate agricultural scientist whose "Green Revolution" have saved a BILLION people from starvation, explains:Norman: You can't build a peaceful world on empty stomachs and human misery.Penn: Norman Borlaug is an amazing man. An amazing man that changed the world. At a time when doomsayers were hopping around saying everyone was gonna starve, Norman was working. He moved to Mexico and lived among the people there till he figured out how to improve the output of the farmers, so that saved a million lives. Then he packed up his family and moved to India where, in spite of a war with Pakistan, he managed to introduce new wheat strains that quadrupled their food output. So that saved, like, another million. You get it? But he wasn't done, he did the same thing with a new rice in China. He's done the same thing in Africa, as much of Africa as he's allowed to visit. When he won the Nobel Prize in 1970 they said he had saved a billion people, that's billion, that's Carl Sagan billion with a B, and most of them were a different race from him. Norman is the greatest human being... and you probably never heard of him.
- Penn's speech about his deceased parents during the episode about mediums who claim to speak with the dead, where he gives his reasoning as to why people like John Edwards are the biggest douches in the universe.
- This was also Houdini's motive to begin debunking the mediums of the 1920s, after the loss of his mother and seeing his friend Arthur Conan Doyle, the creator of the ultra-rational character Sherlock Holmes, become involved with spiritualism over grief at the death of his son in World War I. Houdini told his wife to attempt contact by mediums prior to his death, with a code word to verify if it was him; none ever produced it.
- In a meta sense, this is how Penn and Teller even got the show aired on Showtime in the first place. At the time of 9/11, Penn and Teller were in the early planning stages of Bullshit. Penn predicted that John Edwards would do a "talking to the dead" special for the families of 9/11 victims within six months. Lo and behold, it only took Edwards three months, impressing Showtime execs enough to greenlight the show.
- At the end of the Life Coaching episode, Penn suggests that if you need help dealing with life's problems, instead of paying for a life coach, save that money and get something that will last... *leans on Teller* a friend.
- From the "Stranger Danger" episode, Penn acknowledges that, even after her daughter was kidnapped, raped and murdered, Samantha Runnion's mother, Erin, was still coming at it from a rational standpoint and they just couldn't make any wisecracks.
- Penn gives a sincere thank to Marc Klaas in Death Penalty for telling his story of why he supports the death penalty, despite disagreeing with him. And it's clear that he sympathizes with Klaas's view and understands why Klaas came to these views due to the brutal rape and murder of his daughter.
- One of the final clips of Klaas is him putting up picture frames of his late daughter.
- The romantic-montage of the two lesbians at the end of the "Nukes, Hybrids and Lesbians" video.
- Penn speaking about a 9/11 memorial room and its sacredness.
- The segment in "Fast Food" where Penn takes time to interview the CEO of a major fast food chain (Andy Puzder of Carl's Jr.) and let him defend himself against people that like to blame fast food for America's obesity problems. Penn and Teller make a point of showing their audience that he's not, in fact, some soulless Corrupt Corporate Executive setting out to ruin people's health For the Evulz. He's just a normal guy trying to make an honest buck by selling food that people love—and he takes pride in his work, just like every honest man should.
Heartwarming / Penn & Teller: Bullshit!