- The "Snow Light" chapter — a possible aversion of a similar Black Jack chapter. Fran happens to run into a little girl whose brother desperately needs heart surgery. Despite Fran offering to help, the doctors refuse, stating that the boy will be better off having the operation in America. Fran is upset, but understands for the most part. But then the one-of-a-kind surgeon that was supposed to do the operation is shot and needs time to recover before he can go back to work, time that the little boy doesn't have. Fran uses her skills to heal the surgeon instead, along with making him even more skilled than before. The operation is successful, the little boy lives, and Fran's just happy she could help in her own way.
- The "Attempted Suicide" chapter. For once, the only person who ended up worse off deserved it. A man who tried to commit suicide was "saved" by Fran and left as just a brain, then transplanted into the body of a living, breathing mascot character. While roaming the streets as said character, the suicidal man comes across a little girl who lives in a broken home and is sexually abused by her stepfather. He ends up befriending the girl and tries to rescue her from her stepfather, but he gets mistaken for a child kidnapper. During a police confrontation, the suicidal man finds the girl's abusive stepfather and hands him karmic justice by brutally killing him, getting himself pumped with bullets in the process. As usual, Fran steps in and saves the suicidal man by planting his brain into the stepfather's body, which finally gives him a reason to live as he starts looking after the girl. Meanwhile, the stepfather's brain ends up in the mascot character, trapped in a world surrounded by children and unable to do anything to them with his new body - it's anatomically incorrect and has no apparent sense of touch.
- The "Cosmetic Surgery" chapter. A boy is dating a girl who, because she was sexually assaulted by a man some time ago, Does Not Like Men and freaks out whenever he tries to touch her. He asks Fran to change his sex (including giving him female genitals) so they can have a proper relationship, but it turns out the girl had the same operation that gave her a man's body, parts included, because she didn't want her boyfriend to sacrifice everything for her sake. At the end of the chapter, not only are the boy and girl being happy together while in their new bodies, but we see several of their fellow classmates happily enjoying the results of their various cosmetic surgeries they received from Fran.
- We later find out that the boy and girl broke up after one of them cheated on the other though...
- Beautiful World chapter. The painter who gets eye surgery arguably counts too. Sure, the sweet girl he hooks up with could probably be Saya's sister, but they seem to genuinely love each other, and he goes to thank Fran for his newfound happiness.
- Trivial Love chapter. Even bioweapon horrors can find true love.
- The "Twenty Four" chapter, bringing a whole new meaning to the term "Walk A Mile In My Shoes". Shion, an extremely rich girl, is subjected to extreme emotional neglect from her sycophantic family and relatives, who pretend to love her so they can receive their own share of her vast fortune. Akira, Shion's uncle, requests to Fran that she connect his brain to his niece's body so he can swindle her inheritance, but quickly comes to regret it when he experiences firsthand the living hell that is Shion's life. When the entire family is caught in an explosion, Akira redeems himself by having Fran put all of Shion's family's brains (including his own) into stuffed animals that are connected to Shion's original body, where the only way they can move at all is if they all agree on one thing, making it And I Must Scream for all of them. When Shion (whose brain was transplanted into a clone made by her mother) discovers what her uncle did for her, Akira reveals he did it so that his niece can finally be free, causing Shion to break into tears.
- There's a rather blink-and-miss moment in Aura chapter, where Fran asks Okita and Veronica whether they had somebody they liked, and Okita answers "You", in a very matter-of-factly manner. Dawww.
- The end of the Sea Monster chapter. "Mother. I'm home."
- The chrysalis chapter, watching the relationship between the boy and the girl grow, the backstory where it's revealed that it wasn't looks that attracted the boy to the girl and he is even willing to walk out of the picture once she gets her old body back (since the story started with her rejecting his love). The chapter ends with the two of them sitting side by side in a love hotel looking nervous and then the girl proceeds to turn into a mantis hybrid and devour the boy, because that's what mantis do when they make love (although research suggests that they only do this when being observed in captivity).
- A later chapter implies that she has his child.
- The company president in Rolling World 2 is so moved by the love that the two runaway mascots feel for each other, that he allows Fran to give them human bodies. Then we see their new bodies.
- The ending of Left and Right, the re-union of the two halves of Fran was unexpectedly dramatic, but it worked.
- In the same chapter, after Fran's left-half angrily insults Veronica, Fran's right half comforts her and tells her how much she appreciates her work.
- The very last main chapter, Dream. Seeing every character Fran has ever interacted with throughout the entire series all gather together for her rather symbolic "party"; the epic proportion of the results of all her work, be they good or bad, that stretches across several pages to show. This is her dream, she still remembers them all, and she feels both happy and fulfilled at her efforts. To top it off, Fran finally gets to see her beloved professor, though it's a little sad since it's only a dream. Heartwarming or not, it is an incredibly satisfying chapter to read.
- After seeing Veronica get so harshly picked on during most of the final extra chapter, seeing her sisters hug her when she starts to cry is absolutely adorable.
- "Her Pet Dog" is an odd and somewhat Squicky one. After a girl named Runa loses her dog, Pudding, to a car accident, Fran saves his life by transplanting his brain into the body of a fat, hairy, middle-aged man. Runa has a hard time accepting him, keeps his existence a secret, and eventually considers just abandoning him in the woods. However, after he saves her from some rapists, she changes her mind, and treats him like her old dog again, openly and without any shame. Sadly, Runa comes down with a terminal illness and dies in the hospital. Pudding continues to wait for her every day until he too dies. Despite his disgusting appearance, the locals are actually touched by his loyalty, to the point where they even make a (highly inaccurate) movie about him.
Heartwarming / Franken Fran