This page contains unmarked spoilers. You Have Been Warned!
- In Sander Cohen's apartment, you can find a male and female Splicer slow-dancing together. No violence, no spewing hatred. Just the two of them, deeply in love, enjoying each others company. They won't even attack you unless you disturb them. For the romantic player, it's oddly touching to see that, even in the depths of depravity that Rapture has become, love can still exist.
- The Good Ending: Jack returns to the surface and raises five of the Little Sisters as his own. Each of them live full, enriched lives, and are at Jack's deathbed, each clutching his hand.
- Thanks to Bioshock Infinite, this is the canon ending now.
- The scene which starts the Good Ending. A Little Sister approaches Jack with the Genetic Key. Jack reaches out and the Little Sister shrinks in fear, so he crouches down to her level. She offers the key, but Jack doesn't take it. He gently takes the Little Sister's hand that's holding the key. The city is not his prize, they are.
- This one moment highlights the difference between Jack and his "fathers". Fontaine did absolutely monstrous things in order to take control of Rapture. Ryan did absolutely monstrous things in order to keep control of Rapture. Jack was handed control of Rapture... and turned it down in favor of giving the Little Sisters a better life which Rapture had denied them.
- And in the final battle, the Sisters bum rush Fontaine and drain him of his ADAM after he knocks you out. Jack saved them, so they save him in return.
- Saving each Little Sister is a minor CMOH in itself: you put a gentle hand to the girl's brow and hear her gasp/sigh, along with a few bars of Garry Schyman's achingly sweet violin theme, as everything goes white. When you can see again, she thanks you and scampers off to the nearest vent.
- If you've been saving the Little Sisters throughout the first game, you'll see all of them playing in Tenenbaum's sanctuary. They basically start heaping praises onto you and say you're going to save them. That fact alone can give you the fuzzies. Tenenbaum compliments you for doing so too.Tenenbaum: You have saved many of my Little Ones. I owe you a debt.
- The Little Sisters cheering you on as you battle Fontaine to the death. "Stick it in the bad man!"
- As you learn more about them from conversations and audio diaries, you discover that both the Little Sisters and Big Daddies have been genetically manipulated, surgically altered, and mentally conditioned to the extreme. Most players would naturally assume that the Big Daddies' desire to protect the Sisters would be as artificial and unnatural as the monsters themselves. Yet in Bioshock Infinite; Burial At Sea, you finally learn the truth—every artificial attempt to make the Daddies bond with the Sisters failed miserably. But when two Little Sisters healed an injured Big Daddy using their ADAM, he bonded with them immediately. Elizabeth even quotes "The lion with the thorn in its paw." when the Sisters hug the Big Daddy. The Daddies' willingness to protect the Sisters, even to the death, was a choice born out of love, not science. Somewhere beneath the metal and meat and the countless alterations, the Daddies were still human enough to sincerely love "their" children. A Man Chooses, A Slave Obeys.
- The initial trailer for the game ended with a splicer getting gored to death by the Big Daddy's drill. As a camera cuts to the Little Sister cowering on the ground, the Big Daddy stomps into view towering over her, his drill still covered in blood, and reaches out his huge hand to help her up.
