- For all their perverted tendencies, The Hormone Monsters genuinely care for the kids they are taking care of. Although misguided (as hormones often are), they did everything with the kids' best interests and nature in their minds.
- The fact that Nick's parents are very Happily Married and still in love after all these years, with a great sex life to boot. And they're also very much involved in their kids' lives and despite being somewhat inappropriate at times, they really do go out of their way to reassure Nick that they understand and empathize with the issues he's going through.
- Their warmth even extends to Nick's friends. They consider Andrew family and treat Jay infinitely better than his own family does, which Jay obviously appreciates more than anything.
- Coach Steve clearly cares about all the kids, although he shows it in some pretty bumbling ways.
- Jessi and Matthew's friendship. Matthew is normally mean and bitchy to just about everyone, EXCEPT Jessi, in fact she's the only one he's even remotely nice to and considers a friend, and he hasn't insulted her once, and he often takes the time to insult EVERYONE.
- Even the way Matthew befriends her is hilariously heartwarming.Matthew: You're fucking funny.. She's funny! [links his arm with Jessi's] We're friends now!
- Even the way Matthew befriends her is hilariously heartwarming.
- Nick, Judd and Leah have a typical sibling rivalry, but they're always there for each other.
- Despite being a deadbeat stoner and constantly fighting with her mother, Jessi's father loves her and puts her happiness before anything else.
- Maury's father-like relationship with his dicks.
- Nick gives Andrew his pants after the latter jizzed himself and ruined his own pants (though it didn't help that Andrew tried to clean them in the toilet).
- Coach Steve accidentally buys marshmallows for Jessi instead of pads/tampons, but it's still nice that he tried to help her.
- Leah is very helpful and informative to Nick when he's writing his book report on a romance novel.
- Even though it's a joke, Jessi's conversation with her vagina is not only pleasant but informative. It ultimately teaches her that her body is not scary.
- After Barbara gets upset at Marty and accuses him of not loving her like he used to, he dresses up as Gustavo from the romance novel she's been reading. Sure, he messes it up a little, but it shows how much he cares about her.
- Nick declining a helicopter ride with a girl he likes because Andrew is afraid to fly.
- Missy closing her curtains around her face to Squee when Andrew asks her to be his girlfriend.
- Coach Steve falls in love with the first woman to show him the slightest piece of attention, but she sees him as only a friend (due to her possibly correct assumption that he has some sort of intellectual disability). When she reveals this to him, he isn't upset or insulted but overjoyed to have a friend."You want to be friends? I can't believe you're putting me in the friend zone! That's like the number one zone!"
- Jessi and Matthew go along with Jay's magic act despite previously mocking him for trying it.
- Judd constantly insults Nick but is quick to say that he doesn't hate him and is happy to see him getting along with Tallulah.
- Maurice and Connie's meeting, in what's implied to be the first time they've seen each other in a while, during Andrew and Missy's kiss. They happily remember their first kiss back in Pangea, after the dinosaurs left in their rocket ships.Maurice: It's good to see you Connie.
Connie: It's good to smell you.
- Nick happily helps Leah get revenge on Daniel after the latter assaults her at a party.
- It's a little weird, but Elliot comforting Jay after Nick reconciles with his mom is still sweet.Jay: This is nice.
Elliot: You're wrong Jay. It's dyno-might.
- Andrew and Maurice crying in each other's arms after Missy breaks up with him.
- Jay and Jessi find comfort in each other to avoid their troubled families.
- Maurice's Heroic Sacrifice in "The Pornscape." Not only that, but when he pulls up his "sleeve" when preparing to fight, you can see Connie's name tattooed on his arm. Aww, he really does love her.
- Even though their marriage has fallen apart, Greg and Shannon support Jessi at her soccer game together because they love her.
- Andrew doesn't want to keep obsessing about boobs because he learned that some girls, like Missy, feel bad for not having them.
- Monica brings Missy and Jessi to a Korean spa in order to help them learn to love their bodies and not be ashamed of them.
- Jessi keeps her father company in the basement.
- Jay and Coach Steve bond and become friends.
- This friendship indirectly leads to Jenna letting Jay call her mom.Jay: Yes! Best day ever!
- The three of them have a nice dinner after Coach Steven and Jenna have sex.
- This friendship indirectly leads to Jenna letting Jay call her mom.
- Lars thanks the three guys who take the time and effort to lift him out of his chair to pants him.Lars: Thank you for including me.
- Rick tells Coach Steve that he needs to leave now that the latter isn't a virgin anymore, because he has nothing left to teach him.
- After having an abortion, Barbara rear-ends Marty, who is typically furious. Then she bursts into tears, and Marty immediately stops complaining and comforts her.
- Judd drives Nick home from the hospital after Nick freaked out from getting high for the first time, and didn't rat him out.
- After Matthew gets bitched out by the elderly queen at Guy Town, Andrew tries to reassure him that he isn't just "young, gay and mean".
- Marty defends Elliot from Nick and shows that, while he's annoyed by him, Elliot has earned his respect time and again by being smart and knowing who he is, which is more than what can be said of most people.
- Matthew learns from Jerome, an old gay guy who lives in Guy Town, that he doesn't always have to be bitchy and that he can be vulnerable around others.
- Coach Steve lets Greg stay at his place while Greg looks for a more permanent residence.
- Thanks to some good advice from Marty, Nick successfully asks out Gina, which ends with her kissing him.
- After he sees Jay setting up his sleeping bag in the hallway, Matthew offers to let him stay in the teacher's lounge. The Shame Wizard's interference stops it, but it is a nice gesture.
- Lola reaches out to Gina and the two become (tentative) friends.
- Andrew comforts Missy after she throws away Wiggles by confessing that he came in his pants that time they danced. Missy doesn't judge him, and both feel better after this.
- Coach Steve manages to become friends with the Shame Wizard (or Shane Lizard, as Steve calls him) who even frames the childish doodle Steve did in his office.
- The normally aloof and bitchy Matthew confessing to Jay that he was his first kiss. Jay replies that it was his first boy kiss. They then proceed to make out. This helps Jay come to realize that he likes both girls and boys.
- Leah doesn't hold a grudge against Andrew after catching him masturbating to her swimsuit, and doesn't really do anything to get back at him except some playful ribbing. She understands that he's a kid going through puberty, and that he's going to make stupid decisions.
- Andrew and the Shame Wizard come to terms and become friendlier with each other.
- After Nick sees how Gavin treats Tyler, he admits that he'd prefer having the latter over the former.
- Rick manages to inspire Connie to not give up on Jessi and mount a rescue from the Depression Kitty.
- After Jay accepts his bisexuality, Featuring Ludacris barks the word "proud" and, teary-eyed, says "I'm proud of Jay."
- After a season of hating Shannon, Jessi finally reconciles with her mother.
- After Connie gets devastated by Jessi's rejection, she gets assigned to Nick of all people, and they instantly hit it off.
- In "Girls Are Angry Too" as the girls and boys are divided thanks to Lizer's sexist dress code, Nick at least attempts to try and see from both sides by not wanting to speak against the guys but also trying to speak up for the girls too despite getting heckled by both of them. Sure he fails, as he is only 13 years old and only knows so much, but his attempts are completely genuine in trying to diffuse the situation without taking sides and making sure his friends don't get into it with each other.
- Also, his and Jessi's hug definitely counts too when they reach an understanding and Nick listens to her rant and actually hears her out.
- Principal Baron can't even be bothered to remember the names of the students. But she knows that middle school is hard, so she says there will no longer be any uniforms or sexist dress codes.
- Jessi helps Matthew get together with Aiden.
- Jay's confusion about his own sexuality is resolved by a song from his new favorite character, as it teaches him that sexuality is a spectrum.
- Maury and Jessi are just as excited for Matthew's first date with Aiden as Matthew is, and help him out in anyway they can.
- Judd helps Nick get Cellsea back by breaking the lock of the box she's inside.
- Missy and Jay collaborating on Missy's erotic fanfiction in "Obsessed". It ends up leading to the two truly bonding. They openly share their opinions and suggestions and there's absolutely no judgment between the two of them (compared to the other interactions other characters have between each other).
- After Jay is left behind by his family when they leave for spring break and their house is fumigated, he goes to live with the Birches, who treat him as if he were a member of the family.
- Andrew's parents Barbara and Marty become known for their constant bickering and not exactly equal marriage no thanks to Marty's somewhat obnoxious and selfish attitude as they fought more than showed each other affection save for some moments. However, throughout season 3 their marriage almost seems stronger as Marty shows that he truly does love his wife and the two of them even spice up their sex-life as they make love rather passionately in both "Florida" and "Super Mouth".
- Similarly near the ending of Florida, Marty reassures Barbara when she's feeling insecure about her age and tells her that even after all the years, he still finds her as beautiful as the day they met. Likewise, he stands up to his even more obnoxious father in defense of his wife.Lewis: Are you going to let your wife talk to me that way?
Marty: My wife can do whatever she wants.
Marty: Because she's one hot number six combo.
Lewis: What the hell is that?
Marty: General Tsao's chicken, with a spring roll, and your choice of soft drink.
Barbara: Oh Marty, that's your favorite.
Marty: No. You are.
- Even his niece Cherry is touched by his love for her as she can't help but go 'Aww!'
- Similarly near the ending of Florida, Marty reassures Barbara when she's feeling insecure about her age and tells her that even after all the years, he still finds her as beautiful as the day they met. Likewise, he stands up to his even more obnoxious father in defense of his wife.
- In a really weird way Nick's interactions with Vicki have some heartwarming undertones given Nick's abysmal luck with girls (i.e Jessi, Tallulah, Gina...), and although Vicki is very eccentric and Nick can't tell if she's flirting with him or threatening to kill him, he still gets along with her and she has no problems hanging out with him as they sink a boat together and share a kiss. It's a bit nice to see Nick actually have a somewhat successful fling with a girl after his past failed relationships.
- Right after Featuring Ludacris stops Val and Kurt from attacking Nick, Nick returns the favor by pulling him away as Kurt tries to kick Featuring Ludacris.
- As Featuring Ludacris is bringing Nick home, he says: "My nightmare is over."
- Nick then lets him live in the attic of his house.
- After seeing a peek of what Jay lives through with his messed up brothers, Nick apologies to Jay and the two reconcile.
- In "Duke", it is revealed that Duke Ellington lost his virginity to the girl who dropped her handkerchief on the train, and that handkerchief is what he has been wearing as a memento. Then, as Nick lies back and listens to one of Duke's records, Duke and Maury have a heart-to-heart where Maury admits that Duke was his favorite child.
- For someone as desperate for affection as Lola, it's somewhat sweet for her that Ali says the former would be on the latter's list.
- We get a closer look at Matthew's friendship with Caleb and it is sweet. Caleb appears on the school news as a "statistician" reading lines that Matthew clearly wrote in an attempt to help him sound cool. Matthew also says that Caleb has a "beautiful mind" when he explains how the app calculates the rankings. As bitchy as Matthew can be, Caleb is clearly not one of his targets.
- During Nick and Jessi's deliberately Wangsty song in "Rankings," Connie interrupts to sing about how one day they'll grow up and everybody will appreciate them. While Nick and Jessi don't appreciate this due to their impatience, it's a sweet effort on her part.Someday babies, the clouds will part
The world will take notice
And your life will start
Your talent will shine
Your dick will grow
You'll be the bell of the ball
And the star of the show!
- Gina shares a rather sweet dance with classmate Charles Lu who as far as we know, has done nothing to objectify her or slut-shame her, and she seems genuinely happy as the two of them are even seen hugging while they dance, which is lovely to see especially considering all of the bullying and harassment she received in the previous season.
- Lars tells Missy that the reason he didn't make a list is because she'd be the only one on it.
- Ali sympathizes with Jay after he comes out as bisexual and gets a very lukewarm reception from his friends and classmates, who are either uncomfortable around him, or think he's just doing it for attention. Ali also confides in him the real reason she had to change schools, and then they dance together in a sweet moment of solidarity.
- When Jay tells Diane and Elliot that he's fine with the fact that he doesn't take the ASSes because no one cares, Diane tells him that they care.
- In "The ASSes" and "Super Mouth", Greg's taken more responsibility of himself, gaining a new job, a nicer apartment than in "Guy Town", and starting a new relationship. After his low in season 2, it's nice to see him starting to get his life back together.
- In "The ASSes", he talks Shannon down from putting so much pressure on Jessi after he notices how stressed it's making her.
- When Jessi decides to stay in bed due to the effects of Adderall and the Depression Kitty, her dad is the one who's able to get her to fight off the Depression Kitty's influence and go back to school.
- Connie gives Jessi the encouragement she needs to get over her anxiety and finish the test.
- She goes another route with Nick, and just tells him that he doesn't really care about the test and that it doesn't matter because he's charming, funny, and people want to be around him.
- Jay nominates Coach Steve to the Fab Five to help clean up his life and get his job back. Despite the odd nature of their friendship, Jay clearly takes it seriously and wants to do something nice for his friend.
- After Andrew tells Jessi that he saw Lola giving Mr. Lizer a foot rub, the two of them go talk to Lola and help her realize that Mr. Lizer has been taking advantage of her.
- Amidst the chaotic drama of the rest of the season finale, "Super Mouth", Jay performs another selfless act, this time for his highly dysfunctional family, by cleaning the entire house by himself. They're so moved by the gesture that his brothers start treating him nicer, playing with him in a more friendly way, and his parents are happily kissing.
- In "The New Me" Natalie returns comes to camp after coming out as trans and is getting treated badly from both the girls and the boys. Jessi comes to her defense and befriends her and they end up having a very strong friendship.
- Jay and Lola's relationship is equal parts heartwarming and hilarious. They are actually perfect for each other but that doesn't erase how their insanity fuels the other.
- After Nick bombs the talent show, Jessi tries to comfort him. He blows her off, but it's still sweet that she tried to look out for her friend, especially as everyone else seems to hate him.
- Seeing Andrew and Nick reconcile their friendship at the end of "Poop Madness" after all the shit they put each other through for the first three episodes is really sweet.
- Jay reassures Lola that she is beautiful after she becomes self-conscious about being 6 months older than him.
- At the end of "A Very Special 9/11 Episode", after feeling bad about taking advantage of Coach Steve's naivete for not knowing the significance of 9/11 other than it being his birthday, Matthew leads the bus in singing Happy Birthday to You! to him.
- Nick Starr contemplates bringing one of his parents with him to survive the end of the world. When he obliquely asks them via a hypothetical question, they both respond that they would rather die together, which is implied to be the only reason Nick Starr doesn't go through with inviting one of them to the ark.
- At the end of "The Funeral", Shannon ultimately lets Jessi live with Greg, seeing how unhappy living in the city has made her.
- Missy accepting "Mosaic Missy" as all parts of herself in her identity crisis in "Horrority House". Also a meta one since these are the last words said by Missy's old voice actress Jenny Slate before Ayo Edebiri takes over.
- The Gratitoad is the first supernatural being that isn't a Hormone Monster who doesn't torment everyone he talks to. He helps Jessi get over her anxiety and depression.
- "What Are You Gonna Do?"
- Duke helping out Nick when he's stuck as a lost soul and telling off Rick when the latter (seemingly) nonchalantly agrees with Nick giving up on himself.
- Even though she couldn't hear him, Maury tearing into Matthew's mom for being judgmental is still a really sweet gesture.Maury: Matthew, step out of the room. I'd have a word alone with your mother...
[Matthew stands in the hallway, as glass-breaking sounds come from the kitchen and loud stomps shake the pictures on the wall]
Maury: ARE YOU FUCKING KIDDING ME, KIM?! YOU'VE GOT THE BEST GOD DAMN KID IN THE GAME, SO GET THE FUCK ON BOARD BEFORE YOU LOSE HIM!
- Marty tells Andrew he's proud of his son after Andrew slaps him in the face.
- After Matthew comes out to his father, his dad reveals that he knew all along. And he accepts his son the way he is, which is a huge contrast to how his mother reacted.
- The ending of "What Are You Gonna Do?" is a CMOH for Nick, when he takes the advice of his friends by breathing for four seconds (Andrew), accepting every facet of yourself (Missy) and being grateful for what you have (Jessi). He also reconciles with Connie.
- "The Shane Lizard Rises"
- The Shame Wizard has breakfast with Coach Steve, wherein he confides his insecurities with his friend.
- When Jessi asks what Nick's doing at the hospital, Elliot covers for him by telling her that he's the one who got his penis in a vacuum cleaner.
- Lola's mom's parole officer is able to give the kids (minus Andrew) good advice about accepting their bodies' imperfections.
- Jay is overjoyed that he can share his love of magic with a friend in Charles Lu.
- Shannon and Greg are enjoying each other's company during their Thanksgiving meal. After much of the series with the two having a strained relationship, seeing them together like this makes Jessi happy.
- Jay spends the episode stealing food for his feast because he has nothing at home. However, when he realizes that Lola is also alone and hungry on Thanksgiving, he gives her all the food instead. Even though he wants to pretend he hates her, he still truly cares about her.
- Andrew realizes that his father's angry on Thanksgiving because it's the first one they spent without their grandfather. In an effort to end the cycle of constant anger in the Glouberman family, Andrew tries to have a heart-to-heart with him, letting Marty express emotions besides anger for a change and admit he does miss and love his father.
- Even though Jessi's the reason Samira broke up with her, Ali still lends an ear when Jessi asks for a shoulder to cry on for her troubles.
- Andrew, after getting some advice from Simon Sex, lends Jay an ear when the latter is sad about being a sidepiece.
- Matthew taking Jessi's side when she and Ali are accused of cheating on Samira. The same boy who takes vicious delight in exposing the details of any and all rumors in the school regardless of accuracy doesn't even hint that Jessi might be lying in his broadcast. The two don't get a lot of friendship moments in the 5th season, but he still has her back.
- After Jay makes a big show of wanting Lola back, she accepts and the two are happy together... at least until the relationship falls apart again.
- In the Christmas episode, Lola's Mom's P.O. Rodney comes to check on, and share a meal with, Lola that they both like, but is weird, after both of them got a post card from the latter's mom saying she wouldn't be home again.
- Matthew helps Jay out after the latter hits rock bottom.
- Surprisingly, Leah and Val's relationship in "Sugarbush". After a disaster first time having sex, and the advice of open communication from Diane and Elliot, the two have a honest talk about what they like that leads to their second time being more enjoyable.
- Andrew meets a girl who is equally bad at skiing as himself and has a good time with her.
- Andrew refuses Walter's offer to become his hate worm as he wants to help Nick, not hate him.
- Quinta calls Missy to apologize for what happened at Thanksgiving and offers to help her younger cousin with her hair.
- Missy accepts Jessi's apology so that they can be friends again.
- Missy gets over her hate by being her loving self. This also turns Rochelle into a love bug. Also combined with awesome.
- After three whole seasons since their kiss at the in-school sleepover, when it seemed like Jay and Matthew had a one-time fling together, Matthew realizes that he has true feelings for Jay and at the very end of the season, Jay happily returns his feelings and the two of them become more or less an official couple.
- In a way it's also kind of sweet how Jay, in his own way, tries to let Lola down and explain they're toxic together, gently.
- When Maury questions if Andrew watched his spinoff show, he says he didn't because he can't watch stuff with friends in them, implying he considers Maury his friend.
- Matthew brings Jay home to meet his parents, and his father is absolutely delighted to meet his son's boyfriend. His mother is still upset with her son's homosexuality, but is clearly making an effort to be accepting.
- It's small, but Edward is nudging his wife towards acceptance by watching a sitcom that can help normalize the ideas for middle America without being too offensive. He does just seem to like sitcoms in general but it really does help people adjust, so Will & Grace is a small step.
- After trying a whole episode to introduce Matthew as his "same sex partner" to his whole family and being rejected every single time, Jay instead introduces him to Coach Steve who meets him with nothing but support.
- Elliot reveals his horrible upbringing to Nick, bringing the two closer together.
- When Maury attempts to defend Andrew to Flanny, stating that he has a good heart and deserves love, Flanny suddenly realizes that Maury loves Andrew. This convinces him to give Andrew another chance.Flanny: You genuinely love that little maniac.
- Monica is able to empathize with Missy and help her daughter out after the latter has her first period.
- Caitlin and Jessi bond for the first time after the former helps with the latter's yeast infection and the latter reassures the former by revealing that she herself was born via C-section.Caitlin: Wow. Well, knowing you're a C-section baby, that actually makes me feel a little better.
Caitlin: Yeah, like, maybe this kid will be as awesome as you are.
- Andrew and Bernie wake up together (because their FaceTime kept going after they fell asleep).
- Missy tells Elijah that she's fine with going slow if that's what he wants.
- After being previously resistant to the idea of being a parent, Connie finally decides that she wants to help Maury raise their child.
- The next episode shows her happily playing with Montel after Maury brings the baby to Bridgeton.
- Jay cooks a romantic dinner for his and Matthew's one month anniversary.
- Bernie comforts Andrew after Barbara walks out on Marty.
- After having serious marital problems for the whole season that almost cultivated in a divorce, Marty finally mends the bridge with Barbara (albeit through Andrew) by admitting that he's afraid that he isn't enough for her anymore and thought she would see him as less of a man if he admitted it, apologizing for his jerkass behavior and asserting that he doesn't want to live without her in his life.
- Lola caring for Jesse (actually her infant sister in her body) the entire day, having mistaken Jesse for having been accidentally drugged. This includes picking her up off the floor, standing up for her at school, comforting her while she cries, and potentially even having cleaned her up after she defecated in her leggings. (Jesse's body is shown in clean clothes in the next scene.) It goes to show that, similarly to Jay, Lola is a sweet girl beneath the dysfunction of her horrendous upbringing. When she said she saw Jesse as a new sister, she meant it.
- Rodney is there for Lola no matter what.
- "My Furry Valentine":
- The interactions the Hormone Monsters have with their kids are downright adorable. The winner would have to be when Nick finds Connie at Lola's party and tells her that he's glad he has her in his life. Out of context it looks just like a love confession.
- Matthew and Jessi spend the day being single together. Matthew's attempts at being nicer are a lot less labored than they were in previous episodes, hinting that this might signal a real change for him.
- Jessi accepting her mother's relationship with Dina and telling her that she deserves happiness (after some encouragement from Matthew).
- Matthew finally meets another openly gay boy who swaps phone numbers with him.
- Judd inviting a girl up to his room for a candlelit dinner, coupled with his trained raccoons developing feelings for each other.
- Diane and Elliot don't get mad at Nick for blowing up at them because they understand that this is just part of him growing up.
- After dealing with the awkward tension between him and Gina from last season, Nick casually bumps into her at Lola's party and, after some awkwardness, sincerely wishes her a happy Valentine's Day with no ulterior motives whatsoever. Gina, for her part, returns the gesture resulting in no hard feelings between them.